A5044961881- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Assisted Reproductive Technology and Twin Pregnancy
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Cardiovascular and exercise physiology
- Genetic Associations and Epidemiology
- Pregnancy and preeclampsia studies
- Cardiovascular Disease and Adiposity
- Exercise and Physiological Responses
- Diabetes Treatment and Management
- Helicobacter pylori-related gastroenterology studies
- Thyroid Disorders and Treatments
- Neonatal Health and Biochemistry
- Muscle metabolism and nutrition
- Child Nutrition and Feeding Issues
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Celiac Disease Research and Management
- Neuroscience of respiration and sleep
University of Copenhagen
2016-2025
Copenhagen University Hospital
2018-2025
Holbæk Sygehus
2018-2025
Rigshospitalet
2021-2024
Statens Serum Institut
2024
Background It is imperative to develop markers for risk stratification and detection of cardiometabolic comorbidities in children with obesity. The adipokines leptin adiponectin are both involved fat mass regulation the development obesity-related disorders; furthermore, their ratio (leptin/adiponectin ratio) suggested be associated insulin resistance risk. Objective To evaluate associations between fasting serum concentrations (total as well L/A overweight/obesity. Methods A total 2258...
Abstract Our current understanding of the determinants plasma proteome variation during pediatric development remains incomplete. Here, we show that genetic variants, age, sex and body mass index significantly influence this variation. Using a streamlined highly quantitative spectrometry-based proteomics workflow, analyzed from 2,147 children adolescents, identifying 1,216 proteins after quality control. Notably, levels 70% these were associated with at least one aforementioned factors,...
Pediatric obesity is a progressive, chronic disease that can lead to serious cardiometabolic complications. Here we investigated the peripheral lipidome in 958 children and adolescents with overweight or 373 normal weight, cross-sectional study. We also implemented family-based, personalized program assess effects of management on 186 clinical setting. Using mass spectrometry-based lipidomics, report an increase ceramides, alongside decrease lysophospholipids omega-3 fatty acids metabolism....
Elevated plasma concentrations of liver enzymes are routinely used as markers injury in adults and children. Currently, the age- sex-specific effects adiposity on pediatric enzyme unclear.We included participants from 2 cohorts Danish children adolescents: 1858 a population-based cohort 2155 with overweight or obesity, aged 6 to 18 years. Age- percentile curves were calculated for fasting alanine transaminase (ALT), aspartate (AST), lactate dehydrogenase (LDH), gamma-glutamyltransferase...
The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic outcomes has been questioned.This work aimed to assess whether GLP-1 differs children and adolescents with overweight/obesity compared a population-based reference, concentrations predict cardiometabolic risk (CMR) factors.Analyses were based on Danish Childhood Obesity Data- Biobank, cross-sectional study including adolescents, aged 6 19 years, from an obesity clinic group (n = 1978) 2334). Fasting plasma total...
Birth weight (BW) is associated with risk of cardiometabolic disease (CMD) in adulthood, which may depend on the state obesity, particular if developed at a young age. We hypothesised that BW and polygenic score (PGS) for were related plasma protein levels children adolescents. aimed to determine modifying effect childhood obesity these associations.
Pediatric obesity is associated with multi-organ inflammation and an increased risk of cardiometabolic disease. To identify novel biomarkers early-onset obesity-related risk, we performed targeted proteomics, analyzing 149 proteins related to cardiovascular disease in a cross-sectional sample 2,377 children adolescents overweight/obesity 1,647 normal weight. In addition, analyzed 64 circulating inflammation-related 184 adolescents, who participated 1-year family-based management program. We...
Abstract The levels of specific proteins in human blood are the most commonly used indicators potential health-related problems 1 . Understanding genetic and other determinants plasma proteome can aid biomarker research drug development. Diverse factors including genetics, age, sex, body mass index (BMI), growth development puberty affect circulating 2–5 Affinity-based proteomics infer relationship between protein these at a large scale 6–10 Compared to methods, spectrometry (MS)-based...
Abstract Aims Skeletal muscle lipid stores and mitochondrial function have been appointed as key players in obesity‐induced insulin resistance. However, there are conflicting reports the literature based on vitro quantitative measurements. Here, we test hypothesis that it is not quantity but quality matters. Methods This study combines qualitative structural measurements of dynamics skeletal from lean subjects, subjects with morbid obesity, without type 2 diabetes, before after gastric...
Background Lectin‐like oxidized low‐density lipoprotein (ox‐LDL) receptor‐1 is a scavenger receptor for lipoprotein. In adults, higher soluble lectin‐like ox‐LDL (sLOX‐1) levels are associated with cardiovascular disease, type 2 diabetes, and obesity, but similar link in pediatric overweight/obesity remains uncertain. Methods Results Analyses were based on the cross‐sectional HOLBAEK Study, including 4‐ to 19‐year‐olds from an obesity clinic group body mass index >90th percentile (n=1815)...
Background Alterations in glucose metabolism that lead to the development of metabolic and cardiovascular disease may begin already childhood. Objective This study aims generate pediatric age sex-specific reference values for fasting concentrations glucose, hemoglobin A1c (HbA1c), insulin, C-peptide, homeostasis model assessment: insulin resistance (HOMA-IR) Danish/North-European white children adolescents from a population-based cohort compare with overweight/obesity this reference. Methods...
Do 8- to 9-year-old singletons conceived after frozen embryo transfer (FET) or fresh (Fresh-ET) have increased arterial stiffness compared naturally (NC) children?The process of FET Fresh-ET is not associated with altered cardiovascular function in singletons, including stiffness, as NC children.ART has been suggested influence risk factors (i.e. endothelial dysfunction, blood pressure and insulin resistance). It known if ART procedures alter singletons.A cohort study was carried out, FET,...
A large proportion of patients suffer from a persistent reduction in cardiorespiratory fitness after recovery COVID-19, which the effects on heart may potentially be reversed through effect high-intensity interval training (HIIT). In present study, we hypothesized that HIIT would increase left ventricular mass (LVM) and improve functional status health-related quality life (HRQoL) individuals previously hospitalized for COVID-19. this investigator-blinded, randomized controlled trial, 12 wk...
Abstract Objectives To determine the prevalence of Melanocortin-4 Receptor ( MC4R ) mutations in a cohort children and adolescents with overweight or obesity to whether treatment responses differed between carriers noncarriers. Methods Using target region capture sequencing, an mutation screen was performed 1261 Danish enrolled at tertiary multidisciplinary childhood center. Measurements anthropometrics, blood pressure, fasting biochemistry including lipid hormone levels, dual-energy X-ray...
Background Cardiac magnetic resonance elastography (MRE) shows promise in assessing the mechanofunctional properties of heart but faces clinical challenges, mainly synchronization with cardiac cycle, breathing, and external harmonic stimulation. Purpose To determine reproducibility vivo multifrequency MRE (MMRE) for diastolic left ventricular (LV) stiffness viscosity. Study Type Prospective. Subjects This single‐center study included a total 28 participants (mean age, 56.6 ± 23.0 years; 16...
Thyroid-stimulating hormone (TSH) and thyroid hormones influence the functions of many organ systems, as well child development growth. Several studies have reported an association between ethnicity hormones. This study aims to explore pediatric serum concentrations TSH, free triiodothyronine (fT3), thyroxine (fT4) their relation age sex subsequently present reference intervals from healthy Danish/North-European white children. A population-based cohort in Denmark 2411 (1435 girls) school...
A 17-year-old adolescent with severe multisystem inflammatory syndrome in children (MIS-C) associated coronavirus disease-2019 developed reduced left ventricular function and thrombus. With treatment, his condition improved the thrombus was dissolved. This case illustrates risk of intra-cardiac thrombotic complications patients MIS-C.
Cardiac surgery with cardiopulmonary bypass (CPB) causes an acute lung ischemia-reperfusion injury, which can develop to pulmonary dysfunction postoperatively. This sub-study of the Pulmonary Protection Trial aimed elucidate changes in arterial blood gas analyses, inflammatory protein interleukin-6, and metabolites 90 chronic obstructive disease patients following two protective regimens artery perfusion either hypothermic histidine-tryptophan-ketoglutarate (HTK) solution or normothermic...
Abstract Context In adults, hyperglucagonemia is associated with type 2 diabetes, impaired glucose tolerance, and obesity. The role of glucagon in pediatric overweight/obesity remains unclear. Objective We examined whether fasting concentrations are elevated youth this associates cardiometabolic risk profiles. Methods Analyses were based on the cross-sectional HOLBAEK study, including children adolescents 6 to 19 years age, from an obesity clinic group (n = 2154) normal weight a...