A5090562564- Cardiac electrophysiology and arrhythmias
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Impact on Reproduction
- Prenatal Screening and Diagnostics
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Cardiovascular Issues in Pregnancy
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
- Global Maternal and Child Health
- Adipose Tissue and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Congenital Heart Disease Studies
- Obesity, Physical Activity, Diet
- Nuclear Structure and Function
- Heart Failure Treatment and Management
Statens Serum Institut
2016-2025
University of Iowa
2024-2025
Eden Medical Center
2022-2023
Lundbeck Foundation
2019-2022
Danmarks Nationalbank
2020
Stellenbosch University
2006-2017
Historical Studies in Education
2016
Aarhus University
2015
Copenhagen University Hospital
2013
Rigshospitalet
2012-2013
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a devastating inherited disorder characterized by episodic syncope and/or sudden cardiac arrest during exercise or acute emotion in individuals without structural abnormalities. Although rare, CPVT suspected to cause substantial part of deaths young individuals. Mutations RYR2, encoding the sarcoplasmic calcium channel, have been identified as causative approximately half all dominantly cases. Applying genome-wide linkage...
To explore the impact of COVID-19 lockdown on premature birth rates in Denmark, a nationwide register-based prevalence proportion study was conducted all 31 180 live singleton infants born Denmark between 12 March and 14 April during 2015–2020. The distribution gestational ages (GAs) significantly different (p=0.004) period compared with previous 5 years driven by lower rate extremely children corresponding mean for same dates (OR 0.09, 95% CI 0.01 to 0.40, p<0.001). No significant...
Background— In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share mutation identical descent, represent powerful tool to further understand underlying mechanisms and predict natural history of mutation-associated effects. We are investigating one such founder effect, originating in South Africa approximately ad 1700 segregating same KCNQ1 (A341V). Methods Results— The study population involved 320 subjects,...
The American Heart Association (AHA) recommends family screening for hypertrophic cardiomyopathy (HCM). We assessed the outcome of combining clinical evaluation and sarcomere gene mutations in a cohort 90 Danish HCM patients their close relatives, all 451 persons. Index were screened coding regions 10 genes (MYH7, MYL3, MYBPC3, TNNI3, TNNT2, TPM1, ACTC, CSRP3, TCAP, TNNC1) five exons TTN. Relatives presence minor or major diagnostic criteria tracking DNA variants was performed. In total, 297...
Background— Atrial fibrillation (AF) is the most common cardiac arrhythmia. The sodium channel, Na V 1.5, plays a pivotal role in setting conduction velocity and initial depolarization of myocytes. We hypothesized that early-onset lone AF was associated with genetic variation SCN5A . Methods Results— coding sequence sequenced 192 patients AF. Eight nonsynonymous mutations (T220I, R340Q, T1304M, F1596I, R1626H, D1819N, R1897W, V1951M) 2 rare variants (S216L F2004L) were identified. Of 11...
To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine role hyperandrogenaemia.Cohort study.Singleton pregnancies PCOS identified at a private fertility clinic during 1997-2010 background population including all singleton deliveries Hvidovre Hospital, Denmark, 2005.A cohort 459 5409 women.Obstetric were extracted from national Danish registries odds ratios (ORs) calculated by multiple logistic regression analysis, adjusting for age,...
Background It is imperative to develop markers for risk stratification and detection of cardiometabolic comorbidities in children with obesity. The adipokines leptin adiponectin are both involved fat mass regulation the development obesity-related disorders; furthermore, their ratio (leptin/adiponectin ratio) suggested be associated insulin resistance risk. Objective To evaluate associations between fasting serum concentrations (total as well L/A overweight/obesity. Methods A total 2258...
Atrial fibrillation (AF) is the most frequent arrhythmia. Screening of SCN5A-the gene encoding α-subunit cardiac sodium channel-has indicated that disturbances current may play a central role in mechanism lone AF. We tested hypothesis AF young patients associated with genetic mutations SCN3B and SCN4B, genes two β-subunits channel.In 192 unrelated patients, entire coding sequence splice junctions SCN4B were bidirectionally sequenced. Three non-synonymous found (R6K, L10P, M161T). Two novel...
Obesity is a strong risk factor for hypertension, but the mechanisms by which obesity leads to hypertension are incompletely understood. On this background, we assessed dietary sodium intake, serum levels of natriuretic peptides (NPs), and activity renin-angiotensin system in 63 obese hypertensive men (obeseHT: body mass index, ≥30.0 kg/m(2); 24-hour ambulatory blood pressure, ≥130/80 mm Hg), 40 normotensive (obeseNT: <130/80 27 lean (leanNT: 20.0-24.9 Hg). All study subjects were medication...
Using provisional or opportunistic data, three nationwide studies (The Netherlands, the USA and Denmark) have identified a reduction in preterm extremely births during periods of COVID-19 restrictions. However, none accounted for perinatal deaths. To determine whether births, observed Denmark lockdown, could be result an increase deaths to assess impact extended restrictions, we performed Danish register-based prevalence proportion study. We examined all singleton pregnancies delivered...
Leptin is a hormone which secreted by the adipocytes. In circulation, leptin levels are directly proportional to body fat percentage. Studies have shown that higher associated with an increased risk of hypertension after adjusting for mass index (BMI). Therefore, has been proposed as mediator obesity-related hypertension. Whether when controlling percentage remains unclear. We studied 103 obese men (BMI ≥30.0 kg/m2). All were healthy and medication-free. measured blood pressure using 24-hour...
In this study, we aimed to evaluate incidence trends and potential risk factors associated with Perthes' disease in Denmark, using publicly available data. Our population-based case-control study used data from the Danish National Patient Register Civil Registration System, accessed through Biobank Register, identify 1,924,292 infants born between 1985 2016. We estimated age-specific rates for four birth periods of equal duration (1985 1992, 1993 2000, 2001 2008, 2009 2016) investigated...
Plasmodium falciparum malaria kills nearly a million people annually. Over 90% of these deaths occur in children under five years age sub-Saharan Africa. A neutrophil mediated mechanism, the antibody dependent respiratory burst (ADRB), was recently shown to correlate with protection from clinical malaria. Human neutrophils constitutively express Fc gamma receptor-FcγRIIA and FcγRIIIB by which they interact immunoglobulin (Ig) G (IgG)-subclass antibodies. Polymorphisms exon 4 FCGR2A 3 FCGR3B...
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in genes coding for proteins involved sarcomere function. The disease associated with mitochondrial dysfunction. Evolutionarily developed variation DNA (mtDNA), defining mtDNA haplogroups and haplogroup clusters, functional differences function susceptibility to various diseases, including ischemic cardiomyopathy. We hypothesized that haplogroups, particular H, J K, might modify HCM. Mitochondrial DNA, isolated from...