A5070353503- Ovarian function and disorders
- Reproductive Biology and Fertility
- Ovarian cancer diagnosis and treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Reproductive Health and Technologies
- Reproductive System and Pregnancy
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Regulation of Appetite and Obesity
- Mitochondrial Function and Pathology
- Hormonal and reproductive studies
- Maternal and fetal healthcare
- Endometrial and Cervical Cancer Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Health and Contraception
- Pharmacology and Obesity Treatment
- Trace Elements in Health
- Cancer Risks and Factors
- Bone health and osteoporosis research
- Gestational Diabetes Research and Management
- Endometriosis Research and Treatment
Gentofte Hospital
2021-2025
Herlev Hospital
2017-2024
Dansk Fertilitetsklinik
2023
Copenhagen University Hospital
2005-2018
Hvidovre Hospital
2005-2018
University of Copenhagen
2009
We determined the impact of polycystic ovary syndrome (PCOS) and obesity on glucose lipid metabolism β-cell function in women with PCOS. In 35 PCOS (17 lean, lean 18 obese, obese PCOS) 25 control (9 controls 16 controls), was evaluated by first-phase insulin response after intravenous glucose, acute to (AIRg); sensitivity, as sensitivity index (ISI), euglycemic hyperinsulinemic clamp. Indirect calorimetry used for assessment oxidation. Body composition estimated dual X-ray absorptiometry...
Skeletal muscle molecular mechanisms underlying insulin resistance in women with polycystic ovary syndrome (PCOS) are poorly understood. To provide insight into regulating skeletal who lean PCOS. A hyperinsulinemic-euglycemic clamp biopsies was performed. Thirteen have hyperandrogenism and PCOS seven age- body mass index–matched healthy control subjects were enrolled. protein expression phosphorylation analyzed by Western blotting intramuscular lipid content measured thin-layer...
In response to M. Naylor's valuable critique of our study "Polycystic Ovary Syndrome and Endometrial Cancer Risk: Results from a Nationwide Cohort Study," we recognize the merit in suggested areas. We that including information on hormone therapy may have added understanding relationship between polycystic ovary syndrome (PCOS) endometrial cancer risk. further acknowledge importance frequency gynecological visits, which treated as mediator rather than confounder, given its role reflecting...
Objective. Evaluation of the effect an 8-week very low calorie diet (VLCD, 500–600 kcal daily) on weight, body fat distribution, glucose, insulin and lipid metabolism, androgen levels incretin secretion in obese women. Methods. Seventeen overweight women (BMI >28) were recruited to study. Glucose, metabolism evaluated by euglycemic clamp technique, indirect calorimetry oral glucose tolerance test (OGTT). Insulin sensitivity was calculated as disposal rate (GDR) index (ISI), also HOMA-IR....
Abstract An association between polycystic ovary syndrome (PCOS) and epithelial ovarian tumors is biologically plausible as conditions inherent to PCOS such excessive androgenic hormones, reproductive factors obesity are also risk for these hormone‐sensitive tumors. However, previous studies have showed conflicting results various methodological limitations. This population‐based cohort study investigates the includes all women born in Denmark January 1, 1940 December 31, 1993 (n = 1 719...
Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured respiration in lean and obese women without PCOS using high-resolution respirometry.Hyperinsulinemic-euglycemic clamps (40 mU/min per m(2)) biopsies were performed on 23 (nine (body mass index (BMI) <25 kg/m(2)) 14 (BMI >25 kg/m(2))) 17 age- weight-matched controls (six 11 obese). Western blotting respirometry was used determine...
<title>Abstract</title> <bold>Purpose</bold>: Although some reproductive and metabolic characteristics of polycystic ovary syndrome (PCOS) are known risk factors for breast cancer, the evidence regarding a potential association between PCOS cancer is scarce. In this population-based cohort study including all 1 719 452 women born in Denmark 1940 1993, we investigated cancer. <bold>Methods</bold>: diagnoses, covariates, migrations vital status were obtained from national population- health...
Most previous studies found an elevated risk of endometrial cancer among women with polycystic ovary syndrome (PCOS). However, these had highly varying methods for ascertainment PCOS diagnoses and limitations such as few exposed short follow-up. In this cohort study, we investigated the association between born in Denmark January 1, 1940, December 31, 1993 (n = 1 719 121). Data including covariates, were derived from nationwide registers. We used Cox proportional hazards regression models to...
Polycystic ovary syndrome (PCOS) is associated with infertility, increased androgen levels and insulin resistance. In adipose tissue, zinc facilitates signaling. Circulating are altered in obesity, diabetes, PCOS, supplementation can ameliorate metabolic disturbances PCOS. expression of influx transporter ZIP14 varies body mass index (BMI), clinical markers syndrome, peroxisome proliferator-activated receptor gamma (PPARG). this study, we investigated PPARG subcutaneous tissue 36 PCOS women...
Abstract Background Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, economic consequences. Furthermore, infertility has been linked to adverse long‐term outcomes. Despite the advanced diagnostic therapeutic techniques available, approximately 30% infertile do not obtain live birth after fertility treatment. For these couples, there are no further options increase...
Abstract STUDY QUESTION Is there an association between the length of in vitro culture, mode ART and initial endogenous hCG rise, cycles with a foetal heartbeat after single embryo transfer (ET) implantation? SUMMARY ANSWER Both culture have impact on rise singleton pregnancies. WHAT IS KNOWN ALREADY Different factors been identified to alter kinetics Current studies show conflicting results regarding different types (fresh vs frozen ET (FET)), inclusion or not preimplantation genetic...
Introduction Frozen embryo transfer is being increasingly used for assisted reproductive therapy and offers similar pregnancy rates as treatment with fresh transfer. In women regular menstrual cycles, of a frozen thawed blastocyst can be performed in either natural cycle or substituted cycle. Anovulatory only offered stimulated Knowledge on fetal exposure to estradiol early very limited, but studies mice rats have shown hormonal metabolic disturbances cubs born from estradiol-exposed...
Polycystic ovary syndrome is a condition characterized by hormonal and metabolic disturbances that may affect bone health. The purpose of this study was to investigate the effect polycystic on mineral density examine which clinical characteristics could influence density.We examined 183 premenopausal women: 158 women with 25 healthy age- body mass index matched controls. Bone composition were investigated whole-body dual energy X-ray absorption. Total free testosterone, sex hormone binding...
Abstract Study question Does the length in vitro and mode of ART (fresh frozen cycles) impact se-hCG rise cycles with ongoing single implantation pregnancy? Summary answer Length alter hCG. Blastocysts FET induced higher hCG than clevage stage embryos fresh blastocyst transfers. What is known already Human chorionic gonadotropin (hCG) produced by placental trophoblasts providing first measurable sign pregnancy. Factors, such as multiple pregnancies, advanced maternal age gender fetus are to...
Abstract Study question Is polycystic ovary syndrome (PCOS) associated with epithelial ovarian cancer and borderline tumors? Summary answer Overall, no association between PCOS tumors was seen, however, we observed an increased risk of among postmenopausal women PCOS. What is known already Few studies have investigated the tumors. In general, reported conflicting results, possibly due to methodological differences varying confounder adjustments. For cancer, most associations, while two for...
Introduction: An increasing number of women and couples need oocyte donation to help achieve pregnancy. Several studies have found a correlation between the use adverse obstetrical outcomes such as gestational hypertension preeclampsia. A possible additive risk in using double (oocyte sperm donation) compared solely has been suggested but only sparsely investigated. The aim this study is investigate differences obstetric neonatal after donation.Methods: This retrospective cohort 197 women,...