A5085398435- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Ectopic Pregnancy Diagnosis and Management
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Sperm and Testicular Function
- Gestational Diabetes Research and Management
- HIV Research and Treatment
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Parvovirus B19 Infection Studies
- Reproductive Health and Contraception
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- LGBTQ Health, Identity, and Policy
- COVID-19 and healthcare impacts
Hvidovre Hospital
2016-2025
Copenhagen University Hospital
2017-2025
University of Copenhagen
2006-2024
Engineering Service Center und Handel (Germany)
2021
Rigshospitalet
2020-2021
Statistics Denmark
2020
Novo Nordisk Foundation
2020
Community Link
2020
Is the risk of severe ovarian hyperstimulation syndrome (OHSS) similar in a short GnRH antagonist and long agonist protocol first cycle IVF/ICSI patients less than 40 years age?. There is an increased OHSS group compared with protocol. In most recent Cochrane review, was associated live birth rate (LBR), on-going pregnancy (OPR), lower incidence (odds ratio (OR) = 0.43 95% confidence interval (CI): 0.33–0.57) traditional Previous trials comparing two protocols mainly included selected...
Are cumulative live birth rates (CLBRs) similar in GnRH-antagonist and GnRH-agonist protocols for the first ART cycle including all subsequent frozen–thaw cycles from same oocyte retrieval? The chances of at least one following utilization fresh frozen embryos after are protocols. Reproductive outcomes treatment traditionally reported as pregnancies per or embryo transfer. However, primary concern is overall chance a birth. After with transfer, we found (LBRs) 22.8% 23.8% (P = 0.70)...
To compare the ongoing pregnancy rate between a freeze-all strategy and fresh transfer in assisted reproductive technology treatment.Multicentre, randomised controlled superiority trial.Outpatient fertility clinics at eight public hospitals Denmark, Sweden, Spain.460 women aged 18-39 years with regular menstrual cycles starting their first, second, or third treatment cycle of vitro fertilisation intracytoplasmic sperm injection.Women were baseline on day 2 3 to one two groups: group...
Does maternal infection with severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in first trimester pregnancy have an impact on the fetal development as measured by nuchal translucency thickness and loss?Nuchal at scan was not significantly different pregnant women versus without SARS-CoV-2 early there no increased risk of loss trimester.Pregnant are more vulnerable to viral infections. Previous coronavirus epidemics been associated morbidity, mortality adverse obstetric outcomes....
OBJECTIVE: To investigate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in parturient women, their partners, and newborns association such with obstetric neonatal outcomes. METHODS: From April 4 to July 3, 2020, a single university hospital Denmark, all women partners were invited participate study, along newborns. Participating had pharyngeal swab blood sample taken at admission; immediately after delivery, was drawn from umbilical cord. The swabs...
Passive maternal-fetal transfer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies has been demonstrated, whilst the degree depending on trimester infection is lacking. Due to neonates’ immature immune systems, this knowledge could be interest when investigating early-life protection against SARS-CoV-2. For perinatal infections such as Rubella and Toxoplasmosis, timing related gestational age crucial for severity outcomes; hence, SARS-CoV-2 potentially crucial. So...
What are the attitudes towards different aspects of a freeze-all strategy and elective frozen embryo transfer (eFET) in comparison with fresh assisted reproductive technology treatment among female male patients before after their first ART cycle public health care setting? Despite concerns about delay associated eFET, nearly 60% participants were favor eFET compared assuming that clinical pregnancy rate was equivalent. Vitrification blastocyst have considerably improved success rates FET...
Does women's age affect the DNA methylation (DNAm) profile differently in mural granulosa cells (MGCs) from other somatic cells?Accumulation of epimutations by and a higher number age-related differentially methylated regions (DMR) MGCs were found compared to leukocytes same woman, suggesting that have distinctive epigenetic profile.The mechanisms underlying decline fertility mid-30s remain be fully elucidated. The DNAm many healthy tissues changes predictably with follows chronological age,...
To study the association between sperm deoxyribonucleic acid fragmentation index (DFI) and odds of preeclampsia other adverse perinatal outcomes after in vitro fertilization (IVF) intracytoplasmic injection (ICSI) treatment.
Abstract STUDY QUESTION Does letrozole (LZ) co-treatment during ovarian stimulation with gonadotropins for in IVF impact follicle recruitment, oocyte number and quality, embryo or live birth rate (LBR)? SUMMARY ANSWER No of LZ was found oocytes, quality embryos, LBR. WHAT IS KNOWN ALREADY Multi-follicle produces supra-physiological oestradiol levels. is an aromatase inhibitor that lowers serum thus reducing negative feedback increasing the endogenous both follicular luteal phases,...
Are transfer day, developmental stage and morphology of the competent blastocyst in pregnancies leading to live birth associated with preterm birth, birthweight, length at sex child?A high score trophectoderm (TE) showed a significant association child, while no other associations obstetric outcomes were observed.The between assessment scores have been reported small single-center studies results are conflicting.Multicenter historical cohort study based on exposure data (transfer day...
Abstract Background Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, economic consequences. Furthermore, infertility has been linked to adverse long‐term outcomes. Despite the advanced diagnostic therapeutic techniques available, approximately 30% infertile do not obtain live birth after fertility treatment. For these couples, there are no further options increase...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the male reproductive system as it uses angiotensin-converting enzyme (ACE)2, which is expressed in testicular tissue, an entry point into cell. Few studies have evaluated long-term effects of mild disease 2019 (COVID-19) on function, and insulin-like factor 3 (INSL3) levels not previously been assessed during SARS-CoV-2 infection.
Introduction Pregnancy rates after frozen embryo transfer (FET) have improved in recent years and are now approaching or even exceeding those obtained fresh transfer. This is partly due to laboratory techniques, but may also be caused by a more physiological hormonal endometrial environment FET cycles. Furthermore, the risk of ovarian hyperstimulation syndrome practically eliminated segmentation cycles followed use natural FETs beneficial for postimplantational conditions fetal development....
In assisted reproductive technology, prediction of treatment failure remains a great challenge. The development more sensitive assays for measuring anti-Müllerian hormone (AMH) has allowed the possibility to investigate if lower threshold AMH can be established predicting very limited or no response maximal ovarian stimulation. A prospective observational multicenter study 107 women, < 40 years age with regular menstrual cycle and serum levels ≤ 12 pmol/L, treated 300 IU/day HP-hMG in...
Abstract STUDY QUESTION How does nucleus status at the two-cell stage predict blastocysts formation and clinical outcome after single blastocyst transfer? SUMMARY ANSWER Binucleated embryos (2BI) show higher rates of good quality formation, pregnancy live birth compared to those with one in each blastomere (2MONO), whereas true multinucleated (2MULTI) lower 2MONO embryos. WHAT IS KNOWN ALREADY The introduction time-lapse culture has made it possible study more consistently shows that...
The core of the retrovirus Murine leukemia virus (MLV) consists Gag precursor protein and viral RNA. It assembles at cytoplasmic face cell membrane where, by an unclear mechanism, it collects envelope proteins embedded in buds off. C-terminal half short tail transmembrane (TM) is cleaved off to yield R-peptide fusion-active TM. In Moloney MLV particles, was found bind particles. cells, low amounts uncleaved TM were be associated with small core-like complexes, i.e. mild detergent-insoluble,...
Prediction of pregnancy outcome after in vitro fertilization is important for patients and clinicians. Early plasma human chorionic gonadotropin (p-hCG) levels are the best known predictor outcome, but no studies have been restricted to single embryo transfer (SET) Day-2 embryos. The aim present study was investigate predictive value p-hCG measured exactly 14 days most commonly used SET on pregnancy, delivery, perinatal outcome.A retrospective analysis prospectively collected data 466 women...
Is low-grade inflammation, detected by C-reactive protein (CRP), a marker of IVF outcome addressing both blastocyst quality and pregnancy outcome?This sub-study multicentre randomized controlled trial included 440 women undergoing treatment with gonadotrophin-releasing hormone (GnRH) antagonist protocol. Serum CRP was measured on cycle day 2-3 (baseline) the ovulation triggering. The association between concentrations reproductive outcomes (number retrieved oocytes, number good-quality...