A5088439661- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Genetic Syndromes and Imprinting
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- COVID-19 Impact on Reproduction
Hvidovre Hospital
2019-2024
University of Copenhagen
2023
Copenhagen University Hospital
2019-2022
Abstract STUDY QUESTION Is the fetal fraction (FF) of circulating cell-free DNA (cfDNA) affected in pregnancies following ART treatment with either fresh or frozen embryo transfer (ET) compared natural conception? SUMMARY ANSWER This study shows a significant reduction FF patients naturally conceived pregnancies, which seems to be more pronounced after ET ET. WHAT IS KNOWN ALREADY Non-invasive prenatal testing (NIPT) is based on cfDNA maternal blood, about 10% placental origin and thus...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the male reproductive system as it uses angiotensin-converting enzyme (ACE)2, which is expressed in testicular tissue, an entry point into cell. Few studies have evaluated long-term effects of mild disease 2019 (COVID-19) on function, and insulin-like factor 3 (INSL3) levels not previously been assessed during SARS-CoV-2 infection.
Abstract STUDY QUESTION How does nucleus status at the two-cell stage predict blastocysts formation and clinical outcome after single blastocyst transfer? SUMMARY ANSWER Binucleated embryos (2BI) show higher rates of good quality formation, pregnancy live birth compared to those with one in each blastomere (2MONO), whereas true multinucleated (2MULTI) lower 2MONO embryos. WHAT IS KNOWN ALREADY The introduction time-lapse culture has made it possible study more consistently shows that...
ABSTRACT Introduction Pregnancy loss occurs in 25% of all pregnancies. While 50-60% the pregnancy losses are due to fetal chromosomal and structural abnormalities, incompatible with life, some remaining euploid likely caused by maternal conditions. At least 2% women suffer ≥3 consecutive losses, defined as recurrent (RPL). A hyperactive immune system has been suspected be responsible for rejection healthy fetuses underlying cause unexplained loss. However, very sparsely evidence-based...
Non-invasive prenatal testing (NIPT) for IVF treated-women is sparsely investigated but a few studies indicate decrease in fetal fraction (FF) of cell-free DNA this group. As FF an important parameter NIPT test performance, the relevance high. The study includes patients from “Freeze All” project at Fertility Clinics Hvidovre Hospital and Rigshospitalet, which randomised with transfer fresh embryo exogenous stimulated cycle or frozen thawed following natural cycle. Blood samples analysis...