A5012669567- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Bariatric Surgery and Outcomes
- Obesity and Health Practices
- Adipose Tissue and Metabolism
- COVID-19 Impact on Reproduction
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Pelvic floor disorders treatments
- Breastfeeding Practices and Influences
- Diabetes Management and Research
- Diabetes Management and Education
- Prenatal Substance Exposure Effects
- Gestational Trophoblastic Disease Studies
- Genetic Associations and Epidemiology
- Child Nutrition and Water Access
- Genetic Syndromes and Imprinting
- Prenatal Screening and Diagnostics
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Skin and Cellular Biology Research
- MicroRNA in disease regulation
University of Copenhagen
2012-2025
Herlev Hospital
2023-2025
Gentofte Hospital
2022-2025
Rigshospitalet
2012-2024
Copenhagen University Hospital
2016-2021
University of Padua
2019
Northwestern Medicine
2019
Diabetes Australia
2019
Danish Diabetes Association
2013-2017
University of Southern Denmark
2012
Offspring of women with diabetes during pregnancy have an increased risk glucose intolerance in adulthood, but the underlying mechanisms are unknown. We aimed to investigate effects intrauterine hyperglycemia on insulin secretion and action adult offspring mothers diabetes. A cohort 587 Caucasian offspring, without known diabetes, was followed up at age 18–27 years. included 2 groups exposed maternal utero: gestational mellitus (n = 167) or type 1 153). Two reference were included: factors...
Offspring of women with diabetes in pregnancy are at increased risk type 2 mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: LEP, ADIPOQ, RETN) play key roles the pathophysiology T2DM. We hypothesized that offspring exposed to maternal exhibit alterations regulation subcutaneous adipose tissue (SAT) adipokine transcription. studied plasma levels, SAT gene expression, DNA methylation RETN adult gestational (O-GDM, N = 82)...
Prenatal exposure to maternal hyperglycemia is associated with an increased risk of later adverse metabolic health. Changes in the regulation peroxisome proliferator–activated receptor-γ coactivator-1α (PPARGC1A) skeletal muscle and subcutaneous adipose tissue (SAT) suggested play a role developmental programming dysmetabolism based on studies human subjects exposed abnormal intrauterine environment (e.g., individuals low birth weight). We studied 206 adult offspring women gestational...
OBJECTIVE Since January 2008, obese women with type 2 diabetes were advised to gain 0–5 kg during pregnancy. The aim this study was evaluate fetal growth and perinatal morbidity in relation gestational weight these women. RESEARCH DESIGN AND METHODS A retrospective cohort comprised the records of 58 singleton pregnancies (BMI ≥30 kg/m2) giving birth between 2008 2011. Birth evaluated by SD z score adjust for age sex. RESULTS Seventeen (29%) gained ≤5 kg, remaining 41 >5 kg. median...
Offspring of women with diabetes in pregnancy exhibit skeletal muscle insulin resistance and are at increased risk developing type 2 diabetes, potentially mediated by epigenetic mechanisms or changes the expression small non-coding microRNAs. Members miR-15 family can alter function important proteins signalling pathway, affecting sensitivity secretion. We hypothesized that exposure to maternal may cause altered these microRNAs offspring muscle, representing a potential underlying mechanism...
Introduction The global prevalence of people living with overweight has tripled since 1975 and more than 40% Danish women enter pregnancy being overweight. With the increasing rates obesity observed in children, adolescents adults, there is an urgent need for preventive measures. Risk factors childhood include maternal or before conception excessive weight gain during pregnancy. Interventions aimed at modifying lifestyle have demonstrated minimal positive no impact on health children....
Introduction Gestational diabetes mellitus (GDM) poses health risks due to hyperglycaemia, which can lead clinical complications for mother and child. While dietary therapy serves as first-line treatment, approximately one-third of women with GDM require insulin obtain glycaemic control. However, amplifies hospital care expenses personal burdens. Intensive nutrition education, training support may improve intake leading control reducing the need therapy. This study investigates effectiveness...
Passive maternal-fetal transfer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies has been demonstrated, whilst the degree depending on trimester infection is lacking. Due to neonates’ immature immune systems, this knowledge could be interest when investigating early-life protection against SARS-CoV-2. For perinatal infections such as Rubella and Toxoplasmosis, timing related gestational age crucial for severity outcomes; hence, SARS-CoV-2 potentially crucial. So...
Background Fetal exposure to maternal diabetes increases the risk of type 2 (T2DM), possibly mediated by epigenetic mechanisms. Low blood TXNIP DNA methylation has been associated with elevated glucose levels and T2DM, increased skeletal muscle gene expression was reported in subjects impaired metabolism or T2DM. Subcutaneous adipose tissue (SAT) play a key role control whole body insulin action. The extent which are decreased and/or SAT developmentally programmed at-risk population is...
Abstract Background Diabetes in pregnancy is associated with increased risk of long-term metabolic disease the offspring, potentially mediated by utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites offspring women gestational diabetes mellitus (GDM), but whether stretches regions (DMRs) can also be adolescent GDM unknown. Here, investigate which DNA are blood exposure to pregnancy. The secondary aim was characterize RNA expression DMR,...
Offspring of women with gestational diabetes (O-GDM) or type 1 mellitus (O-T1DM) have been exposed to hyperglycemia in utero and an increased risk developing metabolic disease adulthood. In total, we recruited 206 adult offspring comprising the two fetal hyperglycemic groups, O-GDM O-T1DM, and, as a control group, from background population (O-BP). Subcutaneous fat biopsies were obtained preadipocyte cell cultures established male (n = 18, age 30.1 ± 2.5 years), O-T1DM 31.6 2.2 O-BP 16; age,...
Fetal exposure to maternal diabetes is associated with increased risk of type 2 mellitus (T2DM) later in life. The pathogenesis T2DM involves dysfunction the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well hyperglucagonemia.Our aim was investigate circulating plasma levels GLP-1, GIP, glucagon during oral glucose tolerance test (OGTT) adult offspring women pregnancy.We conducted a follow-up study 567 offspring, aged 18-27...
The aim of this study was to explore the perceptions women with gestational diabetes mellitus (GDM) in Denmark, a particular focus on GDM-specific stigma.We conducted semi-structured interviews 20 GDM from January May 2022. All were transcribed and analysed abductively using Braun Clarke's framework for applied reflexive analysis.Five themes identified, 1) victim-blaming narrative, 2) identity threat, 3) non-disclosure anticipated stigma, 4) stigma clinical setting, 5) reduction setting....
Gestational diabetes mellitus (GDM) has been associated with reduced postprandial glucagon-like peptide 1 (GLP-1) responses. As pregnancy induces changes in gallbladder motility and bile acids stimulate GLP-1 secretion, we investigated emptying responses women GDM.
Maternal gestational diabetes and obesity are associated with adverse outcomes in offspring, including increased risk of cardiovascular diseases. Previously, we identified a lower DNA methylation degree at genomic sites near the genes ESM1, MS4A3, TSPAN14 blood cells adolescent offspring exposed to and/or maternal utero. In present study, aimed investigate if altered expression these were detectable blood, as well metabolically relevant subcutaneous adipose tissue, separate cohort adult...
Abstract The fetal insulin hypothesis proposes that low birthweight and type 2 diabetes (T2D) in adulthood may be two phenotypes of the same genotype. In this study we aimed to explore theory further by testing effects GWAS-identified genetic variants related release sensitivity on growth blood flow from week 20 gestation birth placental weight at birth. We calculated risk scores (GRS) first phase (FPIR), fasting (FI), combined resistance dyslipidaemia (IR + DLD) (IS) a population 665...
Abstract Study question What does the maternal-fetal SARS-CoV-2 antibody transfer look like depending on trimester of infection? Summary answer There is a statistically significant tendency for newborns positive mothers to have higher IgG level compared their mother’s at delivery. known already Passive antibodies has been demonstrated, whilst degree infection lacking, and so far, there no stratification all three trimesters in relation maternal levels women, newborn. It that perinatal...
Abstract Background In order to explore the pathophysiology underlying type 2 diabetes we examined impact of gene variants associated with on circulating levels glucagon during an oral glucose tolerance test (OGTT). Furthermore, performed a genome-wide association study (GWAS) aiming identify novel genomic loci affecting plasma levels. Methods Plasma were in samples obtained at three time points OGTT; 0, 30 and 120 min, two separate cohorts total up 1899 individuals. Cross-sectional analyses...