A5064176745- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare professionals’ stress and burnout
- Dementia and Cognitive Impairment Research
- Mental Health Treatment and Access
- Opioid Use Disorder Treatment
- Posttraumatic Stress Disorder Research
- Bipolar Disorder and Treatment
- COVID-19 and Mental Health
- Digital Mental Health Interventions
- Acute Ischemic Stroke Management
- Menstrual Health and Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Substance Abuse Treatment and Outcomes
- Neuroendocrine regulation and behavior
- Disaster Response and Management
- Neurological Disease Mechanisms and Treatments
- Migration, Health and Trauma
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Sleep and related disorders
- COVID-19 and healthcare impacts
- Diversity and Career in Medicine
- Cerebral Palsy and Movement Disorders
Tel Aviv Sourasky Medical Center
2014-2024
Tel Aviv University
2015-2024
Shaare Zedek Medical Center
2021
Carmel Medical Center
2017
Rabin Medical Center
2016
Geha Mental Health Center
2016
October 6 University
2016
University of New Mexico
2016
Type 2 diabetes mellitus (T2DM) is associated with diseases of the brain, kidney, and vasculature. However, relationship between T2DM, chronic kidney disease, brain alterations, cognitive function after stroke unknown. We aimed to evaluate inter-relationship impaired renal function, pathology on imaging, decline in a longitudinal poststroke cohort.The TABASCO (Tel Aviv acute cohort) prospective cohort stroke/transient ischemic attack survivors. The volume white matter integrity, lesions,...
Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical emergencies, such as stroke. Data suggest that up to 25% of stroke survivors will develop PTSD symptomatology, but little is known about predisposing factors. We sought examine whether neuroimaging measures and coping styles are related symptoms after stroke.Participants were first-ever, mild-moderate ischemic stroke, or transient attack from the TABASCO study (Tel Aviv Brain Acute Stroke Cohort). All...
To evaluate the interrelationship among impaired renal function, brain pathology on imaging, and cognitive decline in a longitudinal poststroke cohort.The Tel Aviv Brain Acute Stroke Cohort study is prospective cohort of mild-moderate ischemic stroke/TIA survivors without dementia who underwent 3T MRI were cognitively assessed at admission for 24 months following stroke. Renal function was evaluated by creatinine clearance (CCl) estimation. The volumes lesions preexisting white matter...
Previous studies suggest that excessive cortisol levels after stroke are associated with cognitive dysfunction. However, limited data exist regarding associations between post-stroke levels, brain abnormalities, genetic factors, and outcome. We sought to study these issues in a longitudinal survivors cohort. Data from 182 cognitively intact ischemic patients the TABASCO were available. Saliva (bedtime post-awakening) assessments obtained on admission, 6, 12, 24 months thereafter. During...
Objectives. Methadone maintenance treatment (MMT) patients may achieve up to a 2-week privilege of methadone take-home doses (THD), which is associated with considerable responsibility. MMT are characterized as having poor sleep quality and low cognitive states. We studied indices status respect THD privileges. Methods. A sample 123 stratified by groups was studied. Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), the Clock Drawing Test (CDT) were performed. Results....
To examine whether depressive symptoms after a stroke or transient ischemic attack (TIA) increase the risk of cognitive impairment and functional deterioration at 2-year follow-up.Participants were survivors first-ever, mild-to-moderate TIA from TABASCO prospective cohort study who underwent 3T magnetic resonance imaging examined by multiprofessional team 6, 12, 24 months event using direct interviews, depression scales, neurologic, neuropsychological, evaluations. The main outcome was...
Fifty-five former opioid addicts who have been methadone maintained patients for 10 or more years and whose urine has tested negative drugs 2 were compared to 99 medication-free years. Groups comparable in age education, but the subjects younger when having started opioids with severe addiction scores. Methadone presented a higher proportion of psychiatric comorbidity chronic pain. Their scores perceived sleep quality cognitive state poorer than individuals. Possible explanations differences...
Current evidence suggest that 25%-33% of stroke-survivors develop post-stroke cognitive impairment (PSCI). The licensed drug Maraviroc, a CCR5-antagonist, is postulated to act via neuroprotective mechanism may offer the potential preventing progression vascular dementia. Our hypothesis: Maraviroc have augment learning skills and performance by affecting synaptic plasticity, along with neuro-inflammatory modulation in patients cerebral small vessel disease (SVD) PSCI.MARCH multi-center,...
In October 2023, Israel sustained a massive terror attack, with 1,300 people murdered, over 240 kidnapped, and millions exposed to the horrors. This study's aim is examine profile of patients arriving emergency department (ED) for psychiatric services during month following compared similar period year prior. this cohort study, we ED large general hospital in center Tel Aviv post-attack previous using t-tests chi-square exams. 256 arrived evaluation and/or treatment, 46 % more than 2022. Of...
Background Empathy refers to the cognitive and emotional reactions of an individual experiences another. Women with premenstrual dysphoric disorder (PMDD) report severe social difficulties during luteal phase their menstrual cycle. Aims This clinical functional magnetic resonance imaging study aimed explore affective empathy in women PMDD, highly symptomatic phase. Method Overall, 32 PMDD 20 healthy controls participated study. The neuroimaging data were collected using a empathy-engaging...
A naturally occurring loss-of-function mutation in the gene for C-C chemokine receptor type 5 (CCR5-Δ32) has recently been reported as a protective factor post-stroke motor and cognitive recovery. We sought to examine whether this also prevented development of depressive symptoms up 2 years after stroke.Participants were survivors first-ever mild moderate ischemic stroke or transient attack from TABASCO prospective study who underwent 3 T MRI at baseline examined by multiprofessional team 6,...
Stigma in physicians†attitudes toward psychiatric patients has been reported as already present medical school. This study examined implementation of an antistigma intervention curriculum to reduce students†stigma psychiatry.
Abstract Background and purpose Stroke small vessel disease cause gait disturbances falls. The naturally occurring loss‐of‐function mutation in the C‐C chemokine receptor 5 gene ( CCR5 ‐Δ32) has recently been reported as a protective factor post‐stroke motor cognitive recovery. We sought to examine whether it also influences balance measures up 2 years after stroke. Method Participants were 575 survivors of first‐ever, mild–moderate ischaemic stroke or transient attack from TABASCO...
Internet addiction is known to be associated with depression. The Addiction Test (IAT) and the Center for Epidemiologic Studies Depression scale (CES-D) depression were studied among non-selective methadone maintenance treatment patients from United States (n = 164) Israel 113). Thirty percent not exposed internet, 2.9% 8) had an "occasional/frequent problem." IAT CES-D scores correlated significantly (p .03). non-exposed group was older, less educated, more benzodiazepine abusers. Unlike...
Background: Current data suggest 25-30% of stroke survivors will develop post-traumatic stress disorder (PTSD) symptomatology. This common and disabling is thought to be caused by exposure a traumatic, life-threatening event. It unrelated severity one the barriers successful recovery from stroke. We have recently reported on naturally occurring loss-of-function mutation (LOFM) in C-C Chemokine receptor 5 gene (CCR5-Δ32) as protective factor post-stroke depression. sought examine whether it...
Abstract Background Post-stroke depression (PSD) is a significant impediment to successful rehabilitation and recovery after stroke. Current therapeutic options are limited, leaving an unmet demand for specific effective options. Our objective was investigate the safety of Maraviroc, CCR5 antagonist, as possible mechanism-based add-on option PSD in open-label proof-of-concept clinical trial. Methods We conducted 10-week trial which ten patients with subcortical cortical stroke, suffering...