A5034962266- HIV, Drug Use, Sexual Risk
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Microfluidic and Capillary Electrophoresis Applications
- Opioid Use Disorder Treatment
- Sex work and related issues
- Microfluidic and Bio-sensing Technologies
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Microbial Community Ecology and Physiology
- Nanopore and Nanochannel Transport Studies
- Viral gastroenteritis research and epidemiology
- Protist diversity and phylogeny
- Syphilis Diagnosis and Treatment
- Forensic Toxicology and Drug Analysis
- COVID-19 Impact on Reproduction
Bio-Rad (United States)
2020-2025
Nation University
2025
Portland State University
2022-2024
Oregon Health & Science University
2021-2024
Oregon Medical Research Center
2024
New York Proton Center
2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2024
Lindsay Unified School District
2024
Emory University
2016-2023
The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but recognition of chronic symptoms termed post-acute sequelae SARS-CoV-2 (PASC) may affect up to 30% all infected individuals. underlying mechanism and source this distinct immunologic condition three months or more after initial remains elusive. Here, we investigated presence S1 protein 46 We analyzed T-cell, B-cell, monocytic subsets both severe patients with (PASC). levels intermediate (CD14+, CD16+)...
Abstract Background The US’ coronavirus disease 2019 (COVID-19) epidemic has grown extensively since February 2020, with substantial associated hospitalizations and mortality; New York State emerged as the national epicenter. We report on extent of testing test results during month March in State, along risk factors, outcomes, household prevalence among initial cases subject to in-depth investigations. Methods Specimen collection for COVID-19 was conducted healthcare settings,...
IMPORTANCEInfection with hepatitis C virus (HCV) is a major cause of morbidity and mortality in the United States, incidence has increased rapidly recent years, likely owing to injection drug use.Current estimates prevalence at state level are needed guide prevention care efforts but not available through existing disease surveillance systems.OBJECTIVE To estimate current HCV infection among adults each US District Columbia during years 2013 2016.DESIGN, SETTING, AND PARTICIPANTS This survey...
Hepatitis B (HepB) vaccines have demonstrated safety, immunogenicity, and efficacy during the past 4 decades (1,2). However, vaccination coverage among adults has been suboptimal, limiting further reduction in hepatitis virus (HBV) infections United States. This Advisory Committee on Immunization Practices (ACIP) recommendation expands indicated age range for universal HepB to now include aged 19-59 years. Removing risk factor assessment previously recommended determine vaccine eligibility...
Abstract Background Public health data signal increases in the number of people who inject drugs (PWID) United States during past decade. An updated PWID population size estimate is critical for informing interventions and policies aiming to reduce injection-associated infections overdose, as well provide a baseline assessments pandemic-related changes injection drug use. Methods We used modified multiplier approach adults injected 2018. deduced estimated nonfatal overdose events among from...
ObjectiveInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic. Emerging results indicate dysregulated immune response. Given the role of CCR5 in cell migration and inflammation, we investigated impact blockade via CCR5-specific antibody leronlimab on clinical, immunological, virological parameters COVID-19 patients.MethodsIn March 2020, 10 terminally ill, critical patients received two doses individual emergency use indication. We analyzed...
Existing health disparities based on race and ethnicity in the United States are contributing to morbidity mortality during coronavirus disease (COVID-19) pandemic. We conducted an online survey of American adults assess similarities differences by with respect COVID-19 symptoms, estimates extent pandemic, knowledge control measures, stigma.
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19), is now pandemic with nearly three million cases reported to date 1 . Although majority COVID-19 patients experience only mild or moderate symptoms, a subset will progress severe pneumonia and distress (ARDS) requiring mechanical ventilation Emerging results indicate dysregulated immune response characterized by runaway inflammation, including cytokine release (CRS), as major...
Peter G. Szilagyi, MD, MPH; Kyla Thomas, PhD; Megha D. Shah, MPH, MS; Nathalie Vizueta, Yan Cui, Sitaram Vangala, Arie Kapteyn, PhD
Options to increase the ease of testing for SARS-CoV-2 infection and immune response are needed. Self-collection diagnostic specimens at home offers an avenue allow people test or without traveling a clinic laboratory. Before this study, survey respondents indicated willingness self-collect COVID-related tests, but hypothetical can differ from post-collection acceptability after participants collect specimens.153 US adults were enrolled in study feasibility patients three (saliva,...
Hepatitis C virus (HCV) infection is a leading cause of liver‐related morbidity and mortality, more than 2 million adults in the United States are estimated to be currently infected. Reducing HCV burden will require an understanding demographic disparities targeted efforts reduce prevalence populations with disproportionate disease rates. We modeled state‐level estimates hepatitis among U.S. by sex, birth cohort, race during 2013‐2016. National Health Nutrition Examination Survey data were...
Porous membranes have been fabricated based on the development of perforated membrane mold [Y. Luo and R. N. Zare, Lab Chip, 2008, 8, 1688-1694] to create a single filter that contains multiple pore sizes ranging from 6.4 16.6 µm inside monolithic three-dimensional poly(dimethylsiloxane) microfluidic structure. By overlapping two filters we are able achieve smaller size openings (2.5 3.3 µm). This operates without any detectable irreversible clogging, which is achieved using cross-flow...
Abstract Background SARS-CoV-2 virus testing for persons with COVID-19 symptoms, and contact tracing those positive, will be critical to successful epidemic control. Willingness of experiencing symptoms seek may determine the success this strategy. Methods A cross-sectional online survey in United States measured willingness if feeling ill under different specimen collection scenarios: home-based saliva, swab, drive-through facility clinic-based swab. Instructions clarified that...
Abstract Introduction Due to factors associated with structural racism, Black men who have sex (MSM) living HIV are less likely be virally suppressed compared white MSM. Most of these data come from clinical cohorts and modifiable reasons for racial disparities need defined in order intervene on inequities. Therefore, we examined baseline viral suppression a community‐based cohort MSM Atlanta, GA. Methods We conducted an observational infection Atlanta. Enrolment occurred June 2016 2017 were...
The National Health and Nutrition Examination Survey (NHANES) underestimates the true prevalence of HCV infection. By accounting for populations inadequately represented in NHANES, we created 2 models to estimate national hepatitis C among US adults during 2017-2020.
Separation of compounds out complex mixtures is a key issue that has been solved for small molecules by chromatography. However, general methods the separation large bio-particles, such as cells, are still challenging. We demonstrate integration imprinted polymeric films (IPF) into microfluidic chip, which preferentially capture cells matching an imprint template, and separate strains cyanobacteria with 80–90% efficiency, despite minimal difference in morphology fluorescence, demonstrating...
Background and Purpose— Recent national state-level trends show a stalling or reversal of previously declining stroke death rates. These may mask local geographic variation changes in mortality. We assessed county-level mortality among adults aged 35 to 64 ≥65 years. Methods— used data from National Vital Statistics Systems Bayesian multivariate space-time conditional autoregressive model estimate age-standardized annual rates for 2010 through 2016 middle-aged (35–64 years) older (≥65 US...
Reported coronavirus disease 2019 (COVID-19) cases underestimate severe acute respiratory syndrome 2 (SARS-CoV-2) infections. We conducted a national probability survey of US households to estimate cumulative incidence adjusted for antibody waning.From August-December 2020 random sample addresses were mailed and self-collected nasal swabs dried blood spot cards. One adult household member completed the mail specimens viral detection total (immunoglobulin [Ig] A, IgM, IgG) nucleocapsid by...
Background: Literature supports integration of active learning strategies into curriculum. Purpose: This article highlights an innovative approach to engage students in application didactic lecture a clinical management scenario through creation neonatal escape game. Methods: A case-based game required critically evaluate laboratory values, assessment findings, and perform calculations solve clues “escape” within 20-minute period. Pre- post-surveys measured confidence related reasoning....
ABSTRACT Objective Recent guidelines suggest that non‐invasive prenatal screening (NIPS) should be offered to all patients with singleton and twin pregnancies. Accurate determination of fetal fraction in cell‐free DNA (cfDNA) is vital for reliable NIPS outcomes. We propose a methylation‐based approach using droplet digital PCR (ddPCR) methylation‐sensitive restriction enzyme (MSRE) digestion quantification as an affordable fast solution. Method Following biomarker discovery early pregnancy...
Hepatitis C virus (HCV) infection is the most common chronic blood-borne in United States and a leading cause of morbidity mortality. Previous analyses US National Health Nutrition Examination Survey (NHANES) indicated approximately 3.6 million noninstitutionalized persons with antibody to HCV (anti-HCV). However, state-level prevalence remains less understood cannot be estimated reliably from NHANES alone.
Innovative laboratory testing approaches for SARS-CoV-2 infection and immune response are needed to conduct research establish estimates of prevalence incidence. Self-specimen collection methods have been successfully used in HIV sexually transmitted can provide a feasible opportunity scale up purposes.The aim this study was assess the willingness adults use different specimen modalities themselves children as part COVID-19 study.Between March 27 April 1, 2020, we recruited 1435 aged 18...