A5046600296- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- AI in cancer detection
- Eosinophilic Disorders and Syndromes
- Lung Cancer Research Studies
- Long-Term Effects of COVID-19
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Gastroesophageal reflux and treatments
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Endometrial and Cervical Cancer Treatments
- Chronic Myeloid Leukemia Treatments
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Nanoparticle-Based Drug Delivery
- HER2/EGFR in Cancer Research
State University of New York
2013-2024
SUNY Downstate Health Sciences University
2015-2024
New York University
2020
Weatherford College
2020
Kings County Hospital Center
2013-2018
NYU Langone Health
2010
St. John's University
2006
Abstract Development of antibody protection during SARS-CoV-2 infection is a pressing question for public health and vaccine development. We developed highly sensitive SARS-CoV-2-specific neutralization assays. Spike protein or Nucleocapsid specific IgG antibodies at titers more than 1:100,000 were detectable in all PCR+ subjects ( n = 115) absent the negative controls. Other isotype (IgA, IgG1-4) also detected. was determined COVID-19 convalescent plasma up to 10,000-fold dilution, using...
Eosinophilic disorders of the gastrointestinal tract are an emerging subset immune pathologies within spectrum allergic inflammation. Esophagitis (EoE), once considered a rare disease, is increasing in incidence, with rate over 1 10,000 US, for unknown reasons. The clinical management EoE challenging, thus there urgent need understanding etiology and pathophysiology this eosinophilic disease to develop better therapeutic approaches. In open label, single arm, unblinded study, we evaluated...
ObjectiveInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic. Emerging results indicate dysregulated immune response. Given the role of CCR5 in cell migration and inflammation, we investigated impact blockade via CCR5-specific antibody leronlimab on clinical, immunological, virological parameters COVID-19 patients.MethodsIn March 2020, 10 terminally ill, critical patients received two doses individual emergency use indication. We analyzed...
The role of immune-oncologic mechanisms racial disparities in prostate cancer remains understudied. Limited research exists to evaluate the molecular underpinnings immune differences African American men (AAM) and European (EAM) tumor microenvironment (TME).A total 1,173 radiation-naïve radical prostatectomy samples with whole transcriptome data from Decipher GRID registry were used. Transcriptomic expressions 1,260 immune-specific genes selected assess between AAM EAM tumors. Race-specific...
Abstract Background African-Americans/Blacks have suffered higher morbidity and mortality from COVID-19 than all other racial groups. This study aims to identify the causes of this health disparity, determine prognostic indicators, assess efficacy treatment interventions. Methods We performed a retrospective cohort clinical features laboratory data patients admitted over 52-day period at height pandemic in United States. was an urban academic medical center New York City, declared COVID-only...
Anatomic pathology reports are an essential part of health care, containing vital diagnostic and prognostic information. Currently, most patients have access to their test results online. However, the complex generally incomprehensible laypeople. Artificial intelligence chatbots could potentially simplify reports.
COVID-19 can present with lymphopenia and extraordinary complex multiorgan pathologies that trigger long-term sequela.Given inflammasome products, like caspase-1, play a role in the pathophysiology of number co-morbid conditions, we investigated caspases across spectrum disease.We assessed transcriptional states multiple using flow cytometry, expression active caspase-1 blood cells from patients acute convalescent stages disease. Non-COVID-19 subject presenting various comorbid conditions...
This is the first report of development and performance a platform that interrogates small noncoding RNAs (sncRNA) isolated from urinary exosomes. The Sentinel™ PCa Test classifies patients with prostate cancer subjects no evidence cancer, miR Sentinel CS stratifies between those low risk (Grade Group 1) intermediate high disease 2-5), HG favorable 1 or 2) 3-5) disease.sncRNAs were extracted exosomes 235 participants interrogated on 4.0 microarrays. Using proprietary selection classification...
Background: Colorectal cancer is the third most deadly among African Americans (AA). When compared to Caucasian (CA), AA present with more advanced disease and lower survival rates. Here, we investigated if differences in tumor immunology could be contributive disparities observed between these populations. Methods: We examined gene expression of non-tumor adjacent tissues from CA by whole transcriptome sequencing, generated scores for immune cell populations NanoString. In addition,...
Abstract Development of antibody protection during SARS-CoV-2 (CoV-2) infection is a pressing question for public health and vaccine development. We developed highly sensitive CoV-2-specific neutralization assays. CoV-2 Spike protein or Nucleocapsid specific IgG antibodies at titers more than 1:100,000 were detectable in all PCR+ subjects (n=87) absent the negative controls. Other isotype (IgA, IgG1-4) also detected. was determined COVID-19 convalescent plasma up to 10,000-fold dilution,...
The purpose of this study was to determine the diagnostic performance chemical shift imaging, compared with that single-echo T2*-weighted for hepatic iron quantification in patients liver disease, and examine confounding effect steatosis.Sixty-three who underwent MRI had concomitant histopathologic analysis were retrospectively assessed. Chemical imaging (n = 49) reviewed by two independent observers. An index each sequence (I(Fe-CSI) I(Fe-T2*), respectively) correlated pathologic grade...
Based on a single rat study by Lillemoe et al, the consensus has been formed to implicate sorbitol rather than sodium polystyrene sulfonate (SPS) as culprit for colon necrosis in humans treated with SPS and sorbitol. We tested hypothesis that experiment was due high osmolality volume of its chemical nature.26 rats underwent 5/6 nephrectomy. They were divided into 6 groups given enema solutions under anesthesia (normal saline, 33% sorbitol, mannitol, normal distilled water). sacrificed after...
Eosinophilic esophagitis (EoE) is defined as esophageal dysfunction in the presence of > 15 intraepithelial eosinophils per high-power field (eos/hpf) either mid or distal esophagus. The current focus EoE pathologic evaluation peak eosinophil count (PEC), although histologic features other than eosinophilic inflammation are also commonly observed. In addition, variance between and esophagus has not been rigorously studied. aim our study was to utilize a recently developed scoring system...
The short stability window of several hours from blood collection to measuring basophil activation has limited the use flow cytometry-based assays in clinical settings. We examine if it is possible extend this 1 day allowing for shipment samples between laboratories. Several options exist reporting results including all measured values directly, calculating ratios and a single value covering results. Each these have different physician.Whole peanut allergic patients were stimulated with four...
Abstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers clinical data survival. Disease-free survival (DFS) overall (OS) were recorded for 60 months post-diagnosis. Fifty four (90%) patients 36 (60%) < 55 years age. Of 40 typeable genotypes, 10 (25%) had 16/18 30 (75%) one non-16/18 20 (50%) 7 (35, 39, 51, 53, 56, 59 68) that are not included nonavalent vaccine. Mixed infections...
Regulatory T cells, lymphocytes marked by expression of the transcription factor Forkhead Box Protein P3 (FoxP3), inhibit activation tumor-specific cells in tumor-draining lymph nodes. Immunohistochemical analyses sentinel nodes (SLNs) from 104 breast cancer patients showed a significant association (p = .0028, Pearson correlation) between number FoxP3+ and size primary invasive ductal carcinoma. In contrast, there was no correlation presence SLN metastases, or other clinicopathological...
Enhancer of Zeste Homolog 2 (EZH2) is a polycomb group protein that has been shown to be involved in the progression multiple human cancers including melanoma. The expression EZH2 normal skin and pre-malignant malignant cutaneous squamous cell carcinoma (SCC) not studied. We examined skin, actinic keratosis (AK), SCC situ, well-differentiated (SCC-WD), moderately-differentiated (SCC-MD) poorly-differentiated (SCC-PD) ascertain whether differentiates these conditions. Immunohistochemical...