A5063249079- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Food Allergy and Anaphylaxis Research
- Cystic Fibrosis Research Advances
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Eosinophilic Esophagitis
- Sinusitis and nasal conditions
- Pleural and Pulmonary Diseases
- Dermatology and Skin Diseases
- Mast cells and histamine
- Contact Dermatitis and Allergies
- Lung Cancer Research Studies
- Tracheal and airway disorders
- Occupational exposure and asthma
UCLouvain
2015-2024
Cliniques Universitaires Saint-Luc
2015-2024
KU Leuven
2003-2024
Université de Caen Normandie
2024
Directorate-General Joint Research Centre
2013-2022
Médecins du Monde
2021
Institut Universitaire de Recherche Clinique
2021
Walloon Excellence in Lifesciences and Biotechnology
2014-2019
Medizinische Hochschule Hannover
2013
Centre Hospitalier du Mans
2008
The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those subcutaneous (SCIT).To determine the effects grass-pollen SLIT on oral mucosal immune cells, local regulatory cytokines, serum allergen-specific antibody subclasses and B cell IgE-facilitated allergen binding (IgE-FAB).Biopsies from mucosa up to 14 SLIT-treated atopics, nine placebo-treated atopics eight normal controls were examined for myeloid dendritic cells (mDCs) (CD1c), plasmacytoid (CD303), mast...
Abstract Allergen immunotherapy (IT) has long-term efficacy in IgE-mediated allergic rhinitis and asthma. IT been shown to modify lymphocyte responses allergen, inducing IL-10 production IgG Abs. In contrast, a putative role for IgA local TGF-β-producing cells remains be determined. 44 patients with seasonal rhinitis/asthma, serum IgA1, IgA2, polymeric (J chain-containing) Abs the major allergen Phl p 5 were determined by ELISA before after 2-year double-blind trial of grass pollen (Phleum...
Abstract Background IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and lung homeostasis. Its regulation alveolar (HAM), the resident phagocytes, remains however unknown. Methods The present study investigated role of intracellular signalling transcription factors controlling production LPS-activated HAM from normal nonsmoking volunteers. Results LPS (1–1000 pg/ml) induced vitro HAM, both at mRNA protein levels. also activated...
In chronic obstructive pulmonary disease (COPD), epithelial changes and subepithelial fibrosis are salient features in conducting airways. Epithelial-to-mesenchymal transition (EMT) has been recently suggested COPD, but the mechanisms relationship to peribronchial remain unclear. We hypothesised that de-differentiation of COPD respiratory epithelium through EMT could participate airway thereby, obstruction. Surgical lung tissue primary broncho-epithelial cultures (in air-liquid interface...
The generation of protective secretory IgA relies on the epithelial polymeric immunoglobulin receptor (pIgR). pIgR expression is reduced in chronic obstructive pulmonary disease (COPD), but correlation to severity and underlying mechanisms remains unknown.To address hypothesis that down-regulation COPD concerns severe relation aberrant programming bronchial epithelium.Surgical lung tissue primary epithelium (cultured air-liquid interface, ALI) obtained from a large series patients (n = 116)...
Abstract In COPD, epithelial changes are prominent features in the airways, such as goblet cell hyperplasia and squamous metaplasia. contrast, it remains unclear whether ciliated cells reduced which pathways dysregulate differentiation. We hypothesized that bronchial lineage specification is dysregulated COPD because of an aberrant reprogramming through transforming growth factor (TGF)-β1. Surgical lung tissue from 81 61 control (smokers non-smokers) patients was assessed for phenotyping by...
Rationale: ACE2 (angiotensin-converting enzyme 2), the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is expressed in type alveolar epithelial cells (AT2) that may play key roles postinjury repair. An imbalance between and ACE has also been hypothesized to contribute lung injury. Objectives: To characterize expression distribution of compare AT2 with endothelial cell disease (COVID-19)-related or -unrelated distress (ARDS) controls. Methods: Lung tissue...
Patients with severe asthma may require maintenance oral corticosteroids (mOCS) for disease control as well systemic corticosteroid (SCS) bursts clinically significant exacerbations. However, mOCS and SCS use are associated adverse effects, which increases patient burden.To assess the real-world corticosteroid-sparing effect of mepolizumab in patients asthma.REALITI-A was a 24-month international, prospective, observational cohort study involving 84 centers across Europe, Canada, United...
The epithelial polymeric immunoglobulin receptor/transmembrane secretory component (pIgR/SC) transports into secretions A (pIgA), which is considered the first line of defense respiratory tract. present study, done with quantitative immunohistochemistry, evaluated expression (SC) and Clara cell protein (CC16) neutrophil infiltration airways eight patients severe chronic obstructive pulmonary disease (COPD) who were undergoing lung transplantation, as compared these processes in six...
T-helper (Th) 2 cytokines are thought to mediate most features of allergic inflammation in atopic asthma. However, it remains unclear whether chemokine pathways direct selective recruitment Th2 cells the airways during human responses. Bronchoalveolar lavage (BAL) was performed 15 nonsmoking mild asthmatics before and 24 h after a fibreoptic segmental allergen challenge, chemokines related T-cell were assayed by ELISA. The Th2-related C-C (CCR)4 ligands, macrophage-derived chemokine/C-C...
Chronic rhinosinusitis (CRS) defines a group of disorders characterized by persistent inflammation the sinonasal tract. Epithelial changes and structural remodelling are present, but whether epithelial differentiation is altered remains uncertain.To evaluate state epithelium in CRS, biopsies from patients with CRS nasal polyps (CRSwNP) or without (CRSsNP), allergic rhinitis (AR), as compared to controls, were processed immunohistochemistry RT-qPCR for terminal (E-cadherin, high molecular...
Myeloid (m) and plasmacytoid (p) dendritic cells (DCs) regulate immune responses to allergens, whereas it remains unclear whether abnormal DC function characterizes patients with airway allergy putative dysfunction exists only in target organs. To evaluate from allergic rhinitis (AR), we assessed nasal, cutaneous as well blood DCs after vivo vitro allergen challenge, respectively.DCs were immunostained nasal skin tissues, cytokine expression was by dual immunofluorescence. Cytokine...