A5001199263- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dermatology and Skin Diseases
- Pharmaceutical studies and practices
- Inhalation and Respiratory Drug Delivery
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Lichen and fungal ecology
- Delphi Technique in Research
- Urticaria and Related Conditions
- Pediatric health and respiratory diseases
- Receptor Mechanisms and Signaling
- Respiratory Support and Mechanisms
Novartis (Belgium)
2009-2024
Novartis (France)
2016
Novartis (China)
2016
Immunoglobulin E (IgE) is the treatment target of omalizumab, a monoclonal antibody indicated in severe allergic asthma. Long-term variability serum total IgE (sIgEtot) asthmatics remains poorly documented. In this prospective study, sIgEtot levels were measured over 1 year at 7 time points 41 treated with high-dose inhaled corticosteroids and long-acting β2 agonists. 33 patients atopic based on least one positive RAST to common aeroallergens. Patients divided into three groups according...
Background: Global Initiative for Chronic Obstructive Lung Disease (GOLD) global strategy (2015) provides guidance the treatment of chronic obstructive pulmonary disease (COPD) with different first-choice options per GOLD category without specification. Objectives: To evaluate level medical experts’ consensus on their preferred within COPD categories. Methods: A two-round Delphi Panel consisting 15 questions was completed by Belgian pulmonologists (n=31) and European (n=10) experts. Results:...
Onbrace is a Belgian non-interventional study evaluating the use of indacaterol (IND), long-acting β<sub>2</sub> agonist indicated for COPD maintenance treatment. Known patients requiring initiation inhaled treatment i) with IND used in monotherapy or combination other (IND group; n=1756); ii) without (comparator n=221) were enrolled. The physician initiated per his/her current daily practice and choice drugs was made at own discretion. Subjective objective measures effectiveness collected...
Long-term variability of serum total IgE (sIgE<sub>tot</sub>) has been reported in asthmatics. This study evaluates the dynamics and factors predictive this variability. sIgE<sub>tot</sub> levels were prospectively measured over 1 year 41 moderate-to-severe asthmatics treated with high-dose inhaled corticosteroids long-acting β<sub>2</sub> agonists (and untreated omalizumab). Patients divided into 3 groups according to their baseline level: low (≤75 IU/mL; n=10), intermediate (76-700 n=20)...
Omalizumab (OMA) (Xolair<sup>®</sup>) is an anti-IgE monoclonal antibody indicated for the maintenance treatment of persistent severe allergic asthma (PSAA). OMA requires (once/twice) monthly injections causing concerns persistence and adherence to treatment; hereto, long-term use was studied in a real-life setting. A prospective observational study conducted over 120 weeks 50 PSAA patients treated with OMA. As from week 16 (evaluation time point clinical response OMA), treatment,...
<b>Introduction:</b> The BEIgE study revealed clear underestimation of sensitizations to perennial aeroallergens (PAAs) in patients with severe asthma (SA). Among the most prevalent were those against <i>Staphylococcus aureus</i> (<i>StA</i>) toxins, which are not routinely tested clinical practice. This follow-up analysis describes airway inflammatory characteristics SA exclusively sensitized one or more <i>StA</i> toxins ('<i>StA</i>-monosensitized' [<i>StA</i>-MS]). <b>Methods:</b>...
<b>Background:</b> In patients with a diagnosis of asthma, there is currently no consensus which allergy tests should be performed to confirm allergy. <b>Aims and Objectives:</b> We aimed gain insight in the decision making testing (severe) asthma Belgium. <b>Methods:</b> Twenty-five respiratory physicians across Belgium were interviewed by means questionnaire. <b>Results:</b> Among physicians, an allergic component suspected for following reasons (in decreasing order importance): seasonal...
<b>Background:</b> In patients with asthma, there is currently no clear consensus which tests should be performed to confirm a diagnosis of allergy. <b>Aims and Objectives:</b> We aimed gain insights in the decision making allergy testing asthma Belgium. <b>Methods:</b> Twenty-five Belgian respiratory physicians were interviewed by means questionnaire. <b>Results:</b> A majority (60%) respondents indicated start, during initial allergic work-up, skin prick (SPT), rather than for specific...
<b>Background:</b> Evaluation of the allergic status is an integral part asthma assessment, as it a modifiable risk factor with potential therapeutic consequences. There are no guidelines on which allergens to test, and there geographical variations. This may lead underestimation prevalence sensitization allergy in severe (SA) population. As number tests can be performed practice limited, need generate local data prioritization ranking. The BEIgE study aimed at describing perennial...