A5074786702- HIV/AIDS Research and Interventions
- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Multiple Myeloma Research and Treatments
- Hepatitis B Virus Studies
- Treatment of Major Depression
- Hepatitis C virus research
- Psoriasis: Treatment and Pathogenesis
- Syphilis Diagnosis and Treatment
- Sex work and related issues
- Research on Leishmaniasis Studies
- Dermatology and Skin Diseases
- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- Malaria Research and Control
- Liver Disease Diagnosis and Treatment
- Electroconvulsive Therapy Studies
- Reproductive Health and Contraception
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Mosquito-borne diseases and control
- Orthopedic Infections and Treatments
- Pneumonia and Respiratory Infections
- HIV/AIDS drug development and treatment
Janssen (Belgium)
2023-2025
Janssen (United Kingdom)
2023
Instituut voor Tropische Geneeskunde
2013-2022
Jackson and Tull (United States)
2021
Antwerp University Hospital
2021
Sihanouk Hospital Center of HOPE
2021
University of Antwerp
2021
Antwerp Management School
2017
Medscape
2016
University of California, Irvine
2016
In the wake of recent outbreak Ebola virus disease (EVD) in several African countries, World Health Organization prioritized evaluation treatment with convalescent plasma derived from patients who have recovered disease. We evaluated safety and efficacy for EVD Guinea.
Early initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected patients who have tuberculosis reduces mortality among with low CD4 counts, but it increases the risk paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS).We conducted this randomized, double-blind, placebo-controlled trial to assess whether prophylactic prednisone can safely reduce incidence IRIS at high for syndrome. We enrolled HIV-infected were initiating ART...
In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, percentage patients with remission is low and relapse high. The efficacy safety esketamine nasal spray compared extended-release quetiapine augmentation therapy, both in combination ongoing treatment selective serotonin reuptake inhibitor (SSRI) serotonin–norepinephrine (SNRI), depression are unknown. Download PDF Research Summary. an...
In cross-sectional studies increased vaginal bacterial diversity has been associated with inflammation which can be detrimental for health. We describe longitudinal changes at 5 visits over 8 weeks in microbiota and immune mediators African women. Women (N = 40) a normal Nugent score all had stable lactobacilli dominated prevailing Lactobacillus iners. Presence of prostate-specific antigen (proxy recent sex) being amenorrhoeic (due to progestin-injectable use), but not cleansing, were...
Background In light of the limitations current case finding strategies and global urgency to improve tuberculosis (TB) case-detection, a renewed interest in active (ACF) has risen. The WHO calls for more evidence on innovative ways TB screening, especially from low-income countries, inform guideline development. We aimed assess feasibility community-based ACF among urban poor Cambodia determine its impact detection, treatment uptake outcome. Methods Between 9/2/2012-31/3/2013 Sihanouk...
Pre-Exposure Prophylaxis (PrEP) is highly effective in reducing the risk for HIV infection among men who have sex with (MSM) and may an important impact slowing down epidemic. Concerns remain however about low adherence, increased behaviour reduced condom use when using PrEP. The aim of this study was to assess these factors prospectively MSM daily event-driven PrEP Belgium.An open-label prospective cohort conducted from October 2017 May 2018 at Institute Tropical Medicine, Antwerp, Belgium....
Bacterial vaginosis (BV) is a difficult-to-treat recurrent condition in which health-associated lactobacilli are outnumbered by other anaerobic bacteria, such as Gardnerella vaginalis. Certain genotypes of G. vaginalis can produce sialidase, while others cannot. Sialidase known to facilitate the destruction protective mucus layer on vaginal epithelium hydrolysis sialic acid glycans mucous membranes. This process possibly facilitates adhesion bacterial cells since it has been linked with...
Daily pre-exposure prophylaxis and event-driven (PrEP) are efficacious in reducing HIV transmission among men who have sex with (MSM). We analyzed baseline data from a PrEP demonstration project "Be-PrEP-ared" Antwerp, Belgium, to understand preferences for daily or MSM at high risk of factors influencing their initial choice.Cross-sectional an open-label prospective cohort study, using mixed methods. Participants preregistered online were screened eligibility tested sexually transmitted...
Adolescents living with HIV (ALHIV) face many psychosocial challenges, including disclosure to others. Given the importance of socialization during adolescent transition process, this study investigated psychological and social factors influencing self-disclosure own status peers. We examined peers, its relationship perceived HIV-related stigma, self-efficacy disclose, self-esteem, support among a sample n = 582 ALHIV aged 13–17 years in Kampala, Uganda, Western Kenya. Data were collected...
In ESCAPE-TRD (NCT04338321), esketamine nasal spray (NS) significantly increased the probability of remission at Week 8, and being relapse-free through 32 after versus quetiapine extended release (XR) in patients with treatment resistant depression (TRD). Here, we explore time course, burden consequences emergent adverse events (TEAEs) phase IIIb ESCAPE‑TRD trial. Patients TRD were randomised 1:1 to NS or XR, dosed per label alongside an ongoing selective serotonin reuptake...
To better understand risk factors for the sexual transmission of hepatitis C viral (HCV) infection among men who have sex with (MSM).Case-control study HIV-infected MSM, attending AIDS Reference Centers in Belgium.Cases were MSM diagnosed HCV between January 2010 and December 2013. For each case, 2 controls randomly selected HIV-positive tested negative around same time as cases identified. Consenting participants interviewed a questionnaire on factors. Medical records abstracted to document...
There are substantial variations between different populations in the susceptibility of Neisseria gonorrhoeae to antimicrobials, and reasons for this largely unexplored. We aimed assess whether population-level consumption antimicrobials is a contributory factor. Using antimicrobial data from 24 countries European Gonococcal Antimicrobial Surveillance Programme IQVIA MIDAS database, we built mixed-effects linear/logistic regression models with country-level cephalosporin, fluoroquinolone,...
It has been speculated that the prevalence of chemsex is increasing in men who have sex with and this may be playing a role spread HIV. We assessed if reported was associated HIV infection clients attending ‘Helpcenter’, Antwerp, between 2011 2017. This HIV/STI testing center offers to HIV-uninfected individuals from key populations including MSM. found an increase reporting condomless use number drugs, ecstasy, amphetamines, GHB cocaine MSM (from 8 17%) but not heterosexuals. Reporting...
Background HIV prevalence differs by more than an order of magnitude between South Africa's racial groups. Comparing the sexual behaviors and other risk factors for transmission different races may shed light on determinants generalized epidemic. Methods Five nationally representative one city-representative population-based surveys behavior were used to assess extent which various co-varied with race in Africa. Results In 2004, was 0.5%, 1%, 3.2% 19.9% 15–49 year old whites, Indians,...
Aims The reasons why antimicrobial resistance in Neisseria gonorrhoeae has emerged explosively certain populations but not others are poorly understood. We hypothesized that population level consumption of antimicrobials plays a role. Methods Using susceptibility data from the World Health Organizations Global Gonococcal Antimicrobial Surveillance Programme and IMS MIDAS database we built linear regression models with country-level cephalosporin, macrolide fluoroquinolone (standard doses/...
HIV therapeutic vaccination aims to improve the immune responses against in order control viral replication without need for combined antiretroviral therapy (cART). iHIVARNA-01 is a novel vaccine combining mRNA delivery and T-cell immunogen (HTI) based on conserved targets of effective antiviral responses. In addition, it holds adequate stimuli required activating antigen presenting cells (APC)s co-activating specific T-cells (TriMix), including human CD40L, constitutively active TLR4...
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Objective: This post hoc analysis of the ESCAPE-TRD trial compared work productivity loss (WPL) and related costs among patients with treatment-resistant depression (TRD) receiving esketamine nasal spray or quetiapine extended release in combination an oral antidepressant. Methods: Adults TRD randomized to receive (56/84 mg) (150-300 combined ongoing antidepressant therapy were included. WPL was assessed using Work Productivity Activity Impairment questionnaire. Least squares (LS) mean...
Background Psoriasis is associated with an increased risk of cardiovascular disease (CVD). Previous studies have found that treatment tumour necrosis factor or interleukin (IL)-17 inhibitors leads to reductions in the systemic inflammation biomarkers neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR) and monocyte/lymphocyte (MLR). Objectives The primary aim this study was evaluate changes NLR, PLR MLR guselkumab compared placebo (VOYAGE I/II), adalimumab I/II) secukinumab...
Background Hormonal contraception has been associated with a reduced risk of vaginal dysbiosis, which in turn prevalence sexually transmitted infections (STIs), including HIV. Vaginal rings are used or developed as delivery systems for contraceptive hormones and antimicrobial drugs STI HIV prevention treatment. We hypothesized that ring (CVR) containing oestrogen enhances lactobacilli-dominated microbial community despite biomass accumulation on the CVR's surface. Methods enrolled 120 women...
Therapeutic vaccinations aim to re-educate human immunodeficiency virus (HIV)-1-specific immune responses achieve durable control of HIV-1 replication in virally suppressed infected individuals after antiretroviral therapy (ART) is interrupted. In a double blinded, placebo-controlled phase IIa multicenter study, we investigated the safety and immunogenicity intranodal administration HIVACAT T cell Immunogen (HTI)-TriMix vaccine. It consists naked mRNA based on cytotoxic lymphocyte (CTL)...
Background Cutaneous leishmaniasis (CL) in Ethiopia, caused by Leishmania aethiopica , is often severe and hard to treat compared CL other species elsewhere. Miltefosine the only oral anti-leishmanial drug, with a favorable side-effect profile routinely available sodium stibogluconate (SSG), but evidence about its use for L . lacking. Methodology principal findings In an observational cohort study, treatment outcomes, safety adherence among patients who required systemic received miltefosine...