A5030853214- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Scoliosis diagnosis and treatment
- Nutrition and Health in Aging
- Cardiomyopathy and Myosin Studies
- MRI in cancer diagnosis
- COVID-19 Clinical Research Studies
- Advanced X-ray and CT Imaging
- Neurogenetic and Muscular Disorders Research
- Inflammatory Bowel Disease
- Pediatric Urology and Nephrology Studies
- Microscopic Colitis
- Assistive Technology in Communication and Mobility
- Bone and Joint Diseases
- COVID-19 and Mental Health
- Advanced Neural Network Applications
- Autism Spectrum Disorder Research
- Body Composition Measurement Techniques
- Cerebrovascular and Carotid Artery Diseases
- Congenital heart defects research
- Musculoskeletal Disorders and Rehabilitation
Mansfield University
2025
University of Nottingham
2020-2025
Ninewells Hospital
2007-2018
NHS Tayside
2007-2018
National Health Service
2008
There is considerable overlap between left ventricular noncompaction (LVNC) and other cardiomyopathies. LVNC has been reported in up to 40% of the general population, raising questions about whether it a distinct pathological entity, remodeling epiphenomenon, or merely an anatomical phenotype. The authors determined prevalence predictors healthy population using 4 cardiac magnetic resonance imaging diagnostic criteria. Volunteers >40 years age (N = 1,651) with no history cardiovascular...
Abstract Background and Objective Inflammatory bowel disease (IBD) fatigue aetiology is poorly understood. This study quantified body composition physical function alongside proton magnetic resonance imaging (1H MRI) spectroscopy (31P MRS) measures of organ structure in quiescent Crohn’s patients (CD) healthy volunteers (HVs), to identify a physiological basis for IBD fatigue. Methods Body was determined using dual-energy X-ray absorptiometry 1H MRI. Knee extensor isometric strength...
Abstract We evaluated the impacts of COVID‐19 on multi‐organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients ( n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited 5–7 months post‐discharge alongside controls 10) with similar age, sex body mass. Perceived fatigue was estimated (Fatigue Severity Scale) conducted: oral glucose tolerance (OGTT) whole‐body fuel oxidation, validated magnetic resonance...
Abstract Purpose To derive reproducibility assessments of ejection fraction (EF) and left ventricular mass (LVM) from short‐axis cardiac MR images acquired at single multiple time‐points on different 1.5T scanner models. Materials Methods Images 15 healthy volunteers were twice using a Magnetom Avanto (Siemens, Erlangen, Germany) once Signa Excite (General Electric, Milwaukee, WI, USA) over four months, analyzed ARGUS MASS Analysis+ software, respectively. Two physicists independently...
Recent improvements in MR image acquisition and post-processing techniques have allowed quantitative kidney volume measurements to be derived from patient studies. These morphological indices can provide "snapshot" assessments that may related function. The study objective was measure cortical total volumes patients with renovascular disease (RVD) using contrast-enhanced angiography (CE-MRA) order assess the reproducibility of technique investigate associations between renal function as...
Unrecognized myocardial infarctions (UMIs) have been described in 19–30% of the general population using late gadolinium enhancement (LGE) on cardiac magnetic resonance. However, these studies focused an unselected cohort including those with known cardiovascular disease (CVD). The aim current study was to ascertain prevalence UMIs a non-high-risk resonance imaging (MRI). A total 5000 volunteers aged >40 years no history CVD and 10-year risk <20%, as assessed by ATP-III score, were recruited...
Purpose To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials Methods A 1528 was scanned. standardized approach taken to acquire steady‐state free precession (SSFP) LV data short‐axis plane, images were quantified commercial software. Six observers undertook segmentation analysis. Results Mean values (±standard deviation, SD) were: ejection...
Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, this effect postulated to be due its on cardiac afterload, atherosclerosis (plaque formation) progression or both, but limited evidence examining these early in disease formation. The aim of the current study examine association between arteriosclerosis, and ventricular remodelling a population at low-intermediate risk. One thousand six hundred fifty-one subjects free clinical < 20% 10 year risk score...
Abstract Purpose: To optimize the contrast agent dose and delivery rate used in a novel whole‐body magnetic resonance angiography (MRA) protocol using 3.0T MR scanner. Materials Methods: Six groups of 20 consenting volunteers underwent MRA, with each group receiving different rate. The arterial tree was divided into 16 segments image quality at anatomical locations, covering whole body, assessed. Qualitative analysis carried out scoring assessment quality, quantitative assessments were...
Short-axis cine images are acquired during cardiac MRI in order to determine variables of left ventricular (LV) function such as ejection fraction (EF), end-diastolic volume (EDV), end-systolic (ESV), stroke (SV) and LV mass. In perfusion assessments this imaging can be performed the temporal window between first pass acquisition delayed enhancement minimise overall scanning time. The objective study was compare pre- post-contrast short-axis 15 healthy volunteers using a two-dimensional...
Abstract Background Heightened fatigue perception and premature exercise are common in inflammatory bowel disease (IBD). Physical deconditioning is greater patients with increased relative to a lower of fatigue, implicating as an aetiological factor. This study used physiology multiparametric Magnetic Resonance Imaging Spectroscopy (MRI/MRS) during comprehensively phenotype quiescent IBD fatigue. Methods Participant body mass regional composition was assessed by DEXA, tknee extensor strength...
Motivation: To perform 23Na MRI to study dynamic studies of changes in tissue sodium concentration in-vivo. Goal(s): demonstrate the application NOise Reduction with DIstribution Corrected (NORDIC) PCA denoising data. Approach: Dynamic timeseries GRE data and NORDIC validate measurement a known change phantom, calf muscle response exercise. Results: allows detection temporal phantom good spatial resolution. This is applied dynamics Impact: provides potential improve low SNR measures on...
Abstract Background Fatigue perception and exercise intolerance are common in inflammatory bowel disease (IBD). The mechanisms unknown, although physical deconditioning is greater fatigued relative to non-fatigued patients, suggesting an aetiological role for deconditioning. To assess peripheral muscle quality Crohn’s (CD), we quantified the time-course of phosphocreatine (PCr) recovery, which wholly mitochondrial dependent, following ischaemic high-intensity CD HV. Methods Participant body...
<h3>Introduction</h3> Unrecognised myocardial infarctions (UMIs) have been described in 19–30% of the population using late gadolinium enhancement (LGE). However these studies focussed on unselected cohorts including those with known cardiovascular disease. The aim current study was to ascertain prevalence UMIs a non-high risk and their physiological significance. <h3>Methods</h3> 5,000 volunteers >40 years no history disease (CVD) 10 year CVD less than 20% were recruited Tayside...
Muscle volume and fat fraction can be quantified from mDIXON scans either manually or using automated processes. Here we compare manual volumes of thigh calf muscle ROIs with an pipeline created FSL&rsquo;s FAST segmentation, to across subject groups their DXA values. Automatic segmentations correlated highly drawn measures (r=.975) as well (r=0.840). Group comparisons show COPD post-COVID patients had significantly lower mass higher fraction. segmentation performs compared derived is...
<h3>Introduction</h3> Initial acute hyperglycaemia is reported in patients during hospitalisation with SARS-CoV-2 infection. However, it unclear what maladaptations occur long-term. Whole-body insulin sensitivity and metabolic flexibility were assessed alongside whole-body regional fat content to provide insight of health status recovering patients. <h3>Methods</h3> Adults recruited at 5–7 months following hospital discharge for severe SARS-Cov2 infection (n=21), along control volunteers...
<b>Introduction:</b> Following hospitalisation with SARS-Cov2 infection a large proportion of individuals report fatigue as persisting symptom. Here, we performed detailed study the muscle for insight into underlying mechanisms. <b>Method:</b> Adults were recruited at 5-7 months following hospital discharge severe (n=21), along control volunteers (n=10) similar age, gender, ethnicity and body mass. Perceived was estimated using severity scale. The short physical performance battery test...