A5013797270- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Metabolism and Genetic Disorders
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Biochemical effects in animals
- Advanced NMR Techniques and Applications
- Clinical Nutrition and Gastroenterology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Muscle metabolism and nutrition
- Atomic and Subatomic Physics Research
- Musculoskeletal Disorders and Rehabilitation
- MRI in cancer diagnosis
- Regulation of Appetite and Obesity
- Gastrointestinal motility and disorders
- Sulfur Compounds in Biology
- Gut microbiota and health
- Dietary Effects on Health
- NMR spectroscopy and applications
- Cardiovascular Function and Risk Factors
- Advanced Neuroimaging Techniques and Applications
- Electron Spin Resonance Studies
- Bariatric Surgery and Outcomes
University of Nottingham
2015-2025
Nottingham Biomedical Research Centre
2021-2025
Singleton Hospital
2025
Mansfield University
2025
Nottingham University Hospitals NHS Trust
2015-2024
Queen's Medical Centre
2023
National Institute for Health Research
2023
NIHR Nottingham Digestive Diseases Biomedical Research Unit
2015-2017
Cell and Tissue Systems (United States)
2013
Abstract Background and Objective Inflammatory bowel disease (IBD) fatigue aetiology is poorly understood. This study quantified body composition physical function alongside proton magnetic resonance imaging (1H MRI) spectroscopy (31P MRS) measures of organ structure in quiescent Crohn’s patients (CD) healthy volunteers (HVs), to identify a physiological basis for IBD fatigue. Methods Body was determined using dual-energy X-ray absorptiometry 1H MRI. Knee extensor isometric strength...
Aim To investigate the acute and longer‐term effects of low ( LGI ) versus high glycaemic index HGI diets on hepatic fat glycogen accumulation related blood measures in healthy volunteers. Methods Eight men (age 20.1 ± 0.4 years, body mass 23.0 0.9 kg/m 2 attended a test day before after 7‐day macronutrient‐ energy‐matched or diet, followed by minimum 4‐week wash‐out period, then returned to repeat intervention with alternative diet. During days, participants consumed either an meal...
Abstract Aims To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials Methods In Part A (cross‐sectional design), 40 MASLD (liver proton density fat fraction [PDFF] ≥5.56%) were recruited to one two groups: (1) normal (NGR) group (glycated haemoglobin [HbA1c] < 42 mmol∙mol −1 [<6.0%]; n = 14) or (2) IGR (HbA1c ≥ [≥6.0%]; 26). B (randomized...
A low dose oral glucose challenge following an overnight fast inhibits further reduction in hepatic glycogen reserves without raising levels above baseline.
Achieving a desired RF transmit field ( B1+ ) in small regions of interest is critical for single-voxel MRS at ultrahigh field. Radio-frequency (RF) shimming, using parallel transmission, requires mapping and optimization, which limits its ease use. This work aimed to generate calibration-free shims predefined target interest, can be applied any participant, produce absolute magnitude (| |).The were found offline by joint optimization on database comprising maps from 11 subjects, considering...
Magnetic resonance spectroscopy (MRS) provides a powerful method of measuring fat fraction. However, previous studies have shown that MRS results give lower values compared with visual estimates from biopsies in fibrotic livers. This study investigated these discrepancies and considered whether tissue water content correction, as assessed by MRI relaxometry, could provide better agreement.110 patients were scanned 1.5 T Philips scanner obtained. Multiple echo (30 × 30 mm volume) was used to...
The aim of this study was to investigate the effects hormonal changes throughout menstrual cycle on moderate exercise induced liver glycogen in healthy women. Preliminary results show variation hepatic stores and following cycle.
Multinuclear spectroscopy requires the use of free breathing acquisitions to achieve acceptable SNR. Here proton is used as an analogue for multinuclear MRS along with dynamic phase imaging characterise effect respiration. Consistent agreement was seen between respiratory bellows trace and timeseries water peak frequency field offset, overlapping primary frequencies on respective Fourier transforms. On a maximum shift 31Hz measured, this equates 0.24ppm which could cause significant line...
The aim of this study was to use 13C MRS compare hepatic glycogen levels before and after an overnight fast following a small breakfast varying carbohydrate quantities (0, 15.5 31g CHO) in children. Liver concentration decreased from 378 ± 141 277 107 mmol l-1 with between visit coefficient variation 21 15 %. There also significant difference the postprandial AUC (P < 0.005) linear CHO ‘dose’ response (R=0.51, P 0.001). This expands knowledge normative storage
Propionate is a short chain fatty-acid absorbed in the colon and metabolised liver with some evidence showing that consumption can increase energy homeostasis. Three healthy participants have been studied to date 31P saturation transfer experiments performed pre 180 minutes post of an inorganic-propionate ester using 1D-slice-selective-ISIS. The exchange rate constant (k) was calculated be higher than previous studies despite similar methodologies. Whilst at this time no conclusions drawn...
Motivation: Bariatric surgery is evaluated by weight loss and diabetes remission, but the mechanism of latter unclear. Goal(s): Use MRI to quantify changes in liver, pancreas subcutaneous adipose tissue (SAT). Approach: Multiparametric fat fraction (FF), T2*, volume, T1 T2 at four timepoints before after bariatric surgery. Results: Significant reduction liver FF from baseline 6-weeks, between post-VLCD volume subsequent time points. Compared a significant increase T2* 6-weeks 6-months,...
Abstract Background Heightened fatigue perception and premature exercise are common in inflammatory bowel disease (IBD). Physical deconditioning is greater patients with increased relative to a lower of fatigue, implicating as an aetiological factor. This study used physiology multiparametric Magnetic Resonance Imaging Spectroscopy (MRI/MRS) during comprehensively phenotype quiescent IBD fatigue. Methods Participant body mass regional composition was assessed by DEXA, tknee extensor strength...
Motivation: The menstrual cycle (MC) has been shown to effect muscle glycogen utilisation during exercise but little is known about the full metabolic or glycogenic effects at varying phases. Goal(s): To explore MC on exercise-induced changes in metabolites and stores. Approach: 13C MRS bloods were acquired from liver leg before after 45 minutes of moderate healthy females. Test day was repeated 4 times 1 week apart throughout MC. Results: Previous findings hormonal utilization confirmed....
Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which designed to reduce circulating blood glucose levels, hepatic influx, insulin resistance and de novo lipogenesis. significant reduction fat content through following 1-week LGI has been reported healthy volunteers. Changes dietary carbohydrates have also shown alter gut microbiota composition lead steatosis the gut-liver axis. There are no available trials...