A5067668659- Chronic Disease Management Strategies
- Medication Adherence and Compliance
- Diabetes Treatment and Management
- Epilepsy research and treatment
- Diabetes Management and Education
- Diabetes Management and Research
- Diet and metabolism studies
- Cardiac Health and Mental Health
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Physical Activity and Health
- Regulation of Appetite and Obesity
- Glycogen Storage Diseases and Myoclonus
- Adolescent and Pediatric Healthcare
- EEG and Brain-Computer Interfaces
- Mobile Health and mHealth Applications
- Liver Disease Diagnosis and Treatment
- Workplace Health and Well-being
- Ergonomics and Musculoskeletal Disorders
- Prion Diseases and Protein Misfolding
- Obesity, Physical Activity, Diet
- Dialysis and Renal Disease Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Infant Health and Development
- Health Promotion and Cardiovascular Prevention
University of Leicester
2017-2024
NIHR Leicester Biomedical Research Centre
2022-2024
University Hospitals of Leicester NHS Trust
2024
National Institute for Health Research
2022
Leicester General Hospital
2018-2020
King Khalid University Hospital
1989-1997
Abstract Objectives To evaluate the impact of a multicomponent intervention (Stand More AT (SMArT) Work) designed to reduce sitting time on short (three months), medium (six and longer term (12 months) changes in occupational, daily, prolonged sitting, standing, physical activity, physical, psychological, work related health. Design Cluster two arm randomised controlled trial. Setting National Health Service trust, England. Participants 37 office clusters (146 participants) desk based...
This is a comparative video-electroencephalographic (EEG) study of typical absence seizures in 4 epileptic syndromes. In 20 patients, 224 absences were recorded and analysed. Significant clinical EEG differences found the seizure patterns childhood epilepsy (CAE), juvenile (JAE), myoclonic with (JMEA) (MAE). Clinically, CAE demonstrated more severe impairment consciousness than JAE while, JMEA, ictal manifestations frequently mild difficult to detect. latter, adolescent patient usually...
We report a prospective clinical and electroencephalographic study of 19 patients with juvenile myoclonic epilepsy absence seizures. Absences began 1 to 9 (4.5 +/- 2.5) years before jerks generalized tonic-clonic Clinical manifestations during the ictus showed great variation, ranging from subtle or no overt features severe impairment consciousness, severity was age related. Simple complex seizures can occur in same patient. The were distinct, many interictal discharges, fragmentation...
This study conducted a cost and cost-benefit analysis of the Stand More AT (SMArT) Work workplace intervention, designed to reduce sitting time. The was cluster two-armed randomised controlled trial involving 37 office clusters (146 desk-based workers) in National Health Service Trust. intervention group received height-adjustable workstation with supporting behaviour change strategies. control continued usual practice. Self-report absenteeism, presenteeism work productivity were assessed at...
SUMMARY: The occurrence of photosensitivity (PS) was examined in 327 Arabs ≥15 years age with epilepsy by intermittent photic stimulation (IPS). A control group 192 nonepileptic were also IPS. Of the epileptic patients, 24 (7.3%) photosensitive, an incidence comparable to that whites contradistinction reported rarity among African blacks. This finding indicates environmental factors, particularly excessive sunshine, does not appear influence PS patients. patients may depend more strongly on...
Aims To determine the incidence and severity of self‐reported hypoglycaemia in a primary care population with type 2 diabetes. The study also aimed to compare by treatment regimen. Materials methods A prospective observational 17 centres throughout UK was conducted. Recruitment based on regimen (metformin alone, sulphonylurea‐, insulin‐ or incretin‐based therapy). Participants were asked keep blood glucose diary self‐report episodes [non‐severe (self‐treated) severe (requiring external...
Abstract Aims To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials Methods In Part A (cross‐sectional design), 40 MASLD (liver proton density fat fraction [PDFF] ≥5.56%) were recruited to one two groups: (1) normal (NGR) group (glycated haemoglobin [HbA1c] < 42 mmol∙mol −1 [<6.0%]; n = 14) or (2) IGR (HbA1c ≥ [≥6.0%]; 26). B (randomized...
Objective To investigate whether a very early invasive strategy (IS)±revascularisation improves clinical outcomes compared with standard care IS in higher risk patients non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods Multicentre, randomised, controlled, pragmatic trial of NSTE-ACS, defined by Global Registry Acute Coronary Events 2.0 score ≥118, or ≥90 at least one additional high-risk feature. Participants were randomly assigned to IS±revascularisation (<90 min from...
To assess the impact of sodium-glucose co-transporter-2 (SGLT2) inhibitor empagliflozin (25 mg once-daily), dietary energy restriction, or both combined, on circulating appetite-regulatory peptides in people with type 2 diabetes (T2D) and overweight obesity.In a double-blind, placebo-controlled trial, 68 adults (aged 30-75 years) T2D (drug naïve metformin monotherapy; HbA1c 6.0%-10.0% [42-86 mmol/mol]) body mass index 25 kg/m2 higher were randomized to (a) placebo only, (b) plus diet, (c)...
Assess effectiveness of a hybrid intervention targeting physical activity in women with prior gestational diabetes.Randomised controlled trial parallel arms. 293 (35.1 ± 5.1 years; 40% ethnic minority) recruited from two hospitals and randomised to routine care or lifestyle comprising group sessions access mobile web app. Primary outcome was change objectively measured at 12 months. Secondary outcomes included self-efficacy for exercise, quality life anxiety depression. Linear regression...
Globally, there are estimated 425 million people with type 2 diabetes (T2D) 80% from low-middle income countries (LMIC). Diabetes self-management education (DSME) programmes a vital and core component of the treatment pathway for T2D. Despite LMIC being disproportionally affected by T2D, no DSME available that meet international federation criterion.The aims were to test feasibility delivering proven effective cost-effective approach used in UK population two urban settings Malawi Mozambique...
Aim To assess the effectiveness of a low-cost pragmatic intervention (structured education and ongoing text message support) to increase daily physical activity in participants 12–48 months after coronary heart disease cardiac event (myocardial infarction, angina or acute syndrome) diagnosis. Methods A single-centre randomised controlled trial 291 adults structured programme (n=145) usual care (n=146). The consisted two 2.5 hour sessions delivered 2 weeks apart, followed by supplementary...
Background Targeted self-management programmes may improve health and increase physical activity (PA) in people with multimorbidity. Aim To investigate the impact of a structured, theoretically driven, group education programme on habitual PA levels Design setting Individually randomised controlled trial 12-month follow-up, involving nine primary care practices Leicestershire, UK. Method In total, 353 adults multimorbidity (age 67.8 years [±9 years], 161 male sex) were to intervention ( n =...
OBJECTIVE Tight, targeted control of modifiable cardiovascular risk factors can reduce complications and mortality in individuals with type 2 diabetes mellitus (T2DM) microalbuminuria. The effects using an electronic “prompt” a treatment algorithm to support treat-to-target approach has not been tested primary care. RESEARCH DESIGN AND METHODS A multicenter, cluster-randomized trial was conducted among care practices across Leicestershire, U.K. outcome the proportion achieving systolic...
Poor adherence to cardiovascular medications is associated with worse clinical outcomes. Evidence for effective education interventions that address medication the primary prevention of disease lacking. The Ready Reduce Risk (3R) study aims investigate whether a complex intervention, involving group plus telephone and text messaging follow-up support, can improve reduce risk.This protocol paper details design rationale development 3R intervention methods used.This an open pragmatic...
Background: Adherence to evidence-based cardiovascular risk factor targets in patients with type 2 diabetes and microalbuminuria has shown long-term reduction mortality morbidity. Strategies achieve such adherence have been delivered at individual patient level are not cost-effective. Health care professional-level intervention the potential promote better lower cost.
<sec> <title>BACKGROUND</title> Adherence to evidence-based cardiovascular risk factor targets in patients with type 2 diabetes and microalbuminuria has shown long-term reduction mortality morbidity. Strategies achieve such adherence have been delivered at individual patient level are not cost-effective. Health care professional-level intervention the potential promote better lower cost. </sec> <title>OBJECTIVE</title> The aim of this study was assess effectiveness a multifactorial...
<sec> <title>BACKGROUND</title> Poor adherence to cardiovascular medications is associated with worse clinical outcomes. Evidence for effective education interventions that address medication the primary prevention of disease lacking. The Ready Reduce Risk (3R) study aims investigate whether a complex intervention, involving group plus telephone and text messaging follow-up support, can improve reduce risk. </sec> <title>OBJECTIVE</title> This protocol paper details design rationale...