A5083992314- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Coronary Artery Anomalies
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Congenital heart defects research
- Vascular anomalies and interventions
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Ion channel regulation and function
- Cardiovascular and Diving-Related Complications
- Pericarditis and Cardiac Tamponade
- Viral Infections and Immunology Research
- Lymphatic Disorders and Treatments
- Medical Imaging and Pathology Studies
- Cardiac Arrest and Resuscitation
University of Amsterdam
2021-2025
Amsterdam University Medical Centers
2019-2024
Leiden University Medical Center
2011-2023
Vrije Universiteit Amsterdam
2019-2023
Emma Kinderziekenhuis
2019-2023
Erasmus MC
2011-2023
VA Greater Los Angeles Healthcare System
2023
TU Dresden
2023
Cedars-Sinai Medical Center
2023
Leiden University
2021-2022
Background— Incidence and prevalence rates for pediatric pulmonary hypertension (PH) arterial (PAH) are unknown. This study describes the nationwide epidemiological features of PH in Netherlands during a 15-year period clinical course PAH. Methods Results— Two registries were used to retrospectively identify children (0–17 years) with PH. Overall, 3263 patients identified due left heart disease (n=160; 5%), lung disease/hypoxemia (n=253; 8%), thromboembolic (n=5; <1%), transient (n=2691;...
Background— Fetal tachyarrhythmia may result in low cardiac output and death. Consequently, antiarrhythmic treatment is offered most affected pregnancies. We compared 3 drugs commonly used to control supraventricular tachycardia (SVT) atrial flutter (AF). Methods Results— reviewed 159 consecutive referrals with fetal SVT (n=114) AF (n=45). Of these, 75 fetuses 36 were treated nonrandomly transplacental flecainide (n=35), sotalol (n=52), or digoxin (n=24) as a first-line agent. Prenatal...
The aim of this study was to assess the prevalence congenital heart defects (CHDs) and persistent pulmonary hypertension neonate (PPHN) in children with Down syndrome (DS) its impact on neonatal factors. It a prospective birth cohort DS born between 2003 2006 registered by Dutch Paediatric Surveillance Unit (DPSU). A CHD occurred 43% 482 trisomy 21. Atrioventricular septal defect found 54%, ventricular 33.3% patent ductus arteriosus 5.8%. incidence PPHN 5.2%, which is significantly higher...
ABSTRACT Objective Congenital heart defects (CHD) are still missed frequently in prenatal screening programs, which can result severe morbidity or even death. The aim of this study was to evaluate the quality fetal images, obtained during second‐trimester standard anomaly scan (SAS) cases CHD, explore factors associated with a diagnosis. Methods In case–control study, all fetus born isolated CHD Northwestern region Netherlands, between 2015 and 2016, were extracted from PRECOR registry....
Congenital heart defects (CHD) are associated with genetic syndromes. Rapid aneuploidy testing and chromosome microarray analysis (CMA) standard care in fetal CHD. Many syndromes remain undetected these tests. This cohort study aims to estimate the frequency of causal variants, particular structural abnormalities sequence fetuses severe CHD at mid-gestation, aid prenatal counselling.Fetuses were extracted from PRECOR registry (2012-2016). We evaluated pre- postnatal results retrospectively...
To study neo-aortic growth and the evolution of valve regurgitation (AR) in patients with transposition great arteries (TGA) after arterial switch operation (ASO) from newborn to adulthood identify at risk.Neo-aortic dimensions (annulus/root/sinotubular junction) were assessed serially 345 TGA who underwent ASO between 1977 2015. Linear mixed-effect models used assess increase over time risk factors for dilatation. Risk factor analysis AR by using time-dependent Cox regression models.After a...
The objective of this study was to assess our 43-year experience with arterial switch operation (ASO) for transposition the great arteries (TGA) by analysing cardiac outcome measures (hospital and late mortality, reoperations catheter interventions, significant coronary artery obstruction) identify risk factors reoperation interventions.A total 490 patients who underwent ASO TGA from 1977 2020 were included in retrospective, single-centre study. Data on intervention hospital survivors...
Abstract Background: Passive leg raising is used to predict who will benefit from fluid therapy in critically ill patients, including children. Patients with a Fontan circulation may have different haemodynamic response challenge by passive raising. Methods: The of 31 paediatric patients the outpatient clinic (median age 14.0 years) and 35 healthy controls 12.8 was evaluated non-invasively echocardiography for assessment of, e.g., velocity time integral across (neo)aortic valve, blood...
Cardiac channelopathies caused by SCN5A mutation are well tolerated most patients. However, the dramatic presentation of a previously healthy 4-month-old girl with life-threatening arrhythmias and subsequent findings in child her family provide evidence that loss-of-function sodium channel mutations can present very early life. An was detected infant, brother, their father. Both siblings manifested recurrent serious during febrile episodes, which followed immunization, as fever nonspecific...
Abstract Aims We aimed to determine whether in children with dilated cardiomyopathy repeated measurement of known risk factors for death or heart transplantation (HTx) during disease progression can identify at the highest adverse outcome. Methods and results Of 137 we included a prospective cohort, 36 (26%) reached study endpoint (SE: all‐cause HTx), 15 (11%) died median 0.09 years [inter‐quartile range (IQR) 0.03–0.7] after diagnosis, 21 (15%) underwent HTx 2.9 [IQR 0.8–6.1] diagnosis....
Background: This study aimed to describe the current practice and results of genetic evaluation in Dutch children with dilated cardiomyopathy evaluate genotype-phenotype correlations that may guide prognosis. Methods: We performed a multicenter observational diagnosed cardiomyopathy, from 2010 2017. Results: One hundred forty-four were included. Initial diagnostic categories idiopathic 67 (47%), myocarditis 23 (16%), neuromuscular 7 (5%), familial 18 (13%), inborn error metabolism 4 (3%),...
Although various determinants of exercise limitation in Fontan patients have been studied, most research has performed who underwent different surgical procedures with differing haemodynamic characteristics. The aim the current study was to evaluate non-invasively measured cardiovascular parameters and their influence on performance paediatric an extracardiac conduit moderate-good systolic ventricular function.Fontan patients, between 8 18 years age, moderate good function were included....
Bosutinib is approved for adults with chronic myeloid leukemia (CML): 400 mg once daily in newly diagnosed (ND); 500 resistant/intolerant (R/I) patients. has a different tolerability profile than other tyrosine kinase inhibitors (TKIs) and potentially less impact on growth (preclinical data). The primary objective of this first-in-child trial was to determine the recommended phase II dose (RP2D) pediatric R/I ND
Objective. To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced node dysfunction. Methods. We reviewed maternal, prenatal, postnatal findings fetuses with SB associated elevated anti-SSA/Ro anti-SSB/La antibodies. Results. Of 6 cases diagnosed prenatally, 3 had isolated persisting after birth a good prognosis. Three severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero spite...
This study aims to evaluate our 45-year experience with the Fontan procedure and identify risk factors for late mortality morbidity.Demographic, preoperative, perioperative postoperative characteristics were retrospectively collected all patients who underwent a in single centre between 1972 2016.The included 277 procedures (44 atriopulmonary connections, 28 Fontan-Björk, 42 lateral tunnels 163 extracardiac conduits). Early failure occurred 17 (6.1%). Median follow-up of cohort was 11.9...
Cardiopulmonary exercise testing is an important tool to predict prognosis in children and adults with heart failure. A much less sophisticated test the 6 min walk test, which has been shown independent predictor for morbidity mortality Therefore, we hypothesized that could be predictive outcome dilated cardiomyopathy. We prospectively included 49 cardiomyopathy ≥6 years who performed a test. Median age was 11.9 (interquartile range [IQR] 7.4–15.1), median time after diagnosis 3.6 (IQR...
Pericardial effusion (PE) after pediatric cardiac surgery is common. Because of the lack a uniform classification presence and severity PE, we evaluated PE altering clinical management: clinically relevant PE. Risk factors for were studied. After surgery, children followed until 1 month surgery. Preoperative variables studied in complete cohort. Perioperative postoperative case-control manner. Patients with without matched on age, gender, diagnosis 1:1 ratio. Multivariate analysis was...