A5077824236- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- Cervical Cancer and HPV Research
- COVID-19 Impact on Reproduction
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
- Respiratory Support and Mechanisms
- Ferroptosis and cancer prognosis
- SARS-CoV-2 detection and testing
- Vibrio bacteria research studies
- Ocular Infections and Treatments
- COVID-19 Pandemic Impacts
- Hepatitis Viruses Studies and Epidemiology
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Genital Health and Disease
- Liver Disease and Transplantation
- Respiratory viral infections research
Tehran University of Medical Sciences
2011-2024
University of Tehran
2023-2024
Baqiyatallah University of Medical Sciences
2017
Human papilloma virus (HPV) causes the most common sexually-transmitted infection especially among sexually-active individuals. The aim of study was to characterize molecular characterization HPV genotypes between 5176 female and male patients.HPV DNA extracted from genital swabs participants amplified by Real Time Polymerase Chain Reaction (PCR). Genotyping performed for 2525 cases using REALQUALITY RQ-Multi Detection Kit identification 14 high risk (HR) 2 low (LR) genotypes. Demographic...
Coronavirus disease 2019 (COVID-19) is an infectious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but pathogenesis unclear. Host genetic background one of main factors influencing patients' susceptibility to several viral diseases. This study aimed investigate association between host polymorphisms two genes, including vitamin D receptor (VDR) and binding protein (DBP), COVID-19 in a sample Iranian population. case-control enrolled 188 hospitalized patients as...
The SARS-CoV-2 virus has been rapidly spreading globally since December 2019, triggering a pandemic, soon after its emergence. While Iran was among the first countries confronted with rapid spread of in February 2020, no real-time whole-genome tracking early phase outbreak performed country. To address this issue, we provided 50 sequences viral isolates ascertained from different geographical locations during March–July 2020. corresponding analysis on origins, transmission dynamics and...
The objectives of this study were to analyze the clinical features and laboratory profiles risk factors associated with critical illness children severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).One hundred sixty-six disease 2019 (COVID-19) Iranian pediatric patients recruited through a collaborative research network between March May 2020. Demographics, clinical, laboratory, radiological results obtained from patient files.Of 166 patients, 102 (61%) 64 (39%) males females,...
Complete SARS-CoV-2 genome sequencing in the early phase of outbreak Iran showed two independent viral entries. Subsequently, as part a surveillance project, we aimed to characterize genetic diversity over one year after emerging.We provided 319 whole-genome sequences used monitor circulating lineages March 2020-May 2021 time interval.The temporal dynamics major clades/lineages is comparable global perspective and represent 19A clade (B.4) dominating first disease wave, followed by 20A...
Occult hepatitis B infection (OBI) has been described in various clinical settings including after virus (HBV) immunization. The purpose of study was to characterize the prevalence OBI among immunized children from a subset general population and parents OBI-positive cases.Sera 1200 who have previously by HBV vaccine were assayed for anti-HBs. 660 randomly selected DNA testing different polymerase chain reaction (PCR) methods analysed direct sequencing on surface genes.None participants...
The impact of viral keratitis (VK) on individuals and society is notable. Early diagnosis treatment are crucial in managing effectively. Timely intervention with antiviral medications supportive care can help mitigate the severity infection improve visual outcomes. We examined prevalence varicella-zoster virus (VZV), herpes simplex type 1 (HSV-1), adenovirus (AdV) 2 (HSV-2) patients suspected for ocular infections. Patients included study exhibited various clinical manifestations indicative...
The analysis of the gene expression peripheral blood mononuclear cells (PBMCs) is important to clarify pathogenesis hepatocellular carcinoma (HCC) and detection suitable biomarkers. purpose this investigation was use RNA-sequencing screen appropriate differentially expressed genes (DEGs) in PBMCs for HCC.The comprehensive transcriptome extracted RNA PBMC (n = 20) from patients with chronic hepatitis B (CHB), liver cirrhosis, early stage HCC (5 samples per group) carried out using...
Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients admitted to intensive care units (ICUs). Objective: Herein, we aimed describe differences in demographic characteristics, laboratory findings, presentations, and outcomes Iranian ICU versus those non-ICU settings. Methods: This multicenter investigation involved 15 general pediatrics hospitals included cases with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
Background: The coronavirus disease 2019 (COVID-19) poses a threat to the global economy and public health. Mutations in spike protein of virus can impact functional characteristics effectiveness vaccines. Objectives: This study aimed analyze mutations three key regions protein, investigate clinical presentations, assess protective immune levels healthcare workers (HCWs) who had received full vaccine doses but were re-infected. Methods: In this cross-sectional study, 49 breakthrough-infected...
Background and Objectives: Host genetic changes like single nucleotide polymorphisms (SNPs) are one of the main fac- tors influencing susceptibility to viral infectious diseases. This study aimed investigate association between host SNP Toll-Like Receptor3 (TLR3) Receptor7 (TLR7) genes involved in immune system susceptibil- ity COVID-19 a sample Iranian population. Materials Methods: retrospective case-control evaluated 244 hospitalized patients as case group 156 suspected with mild signs...
Abstract The SARS-CoV-2 virus has been rapidly spreading globally since December 2019, triggering a pandemic, soon after its emergence, with now more than one million deaths around the world. While Iran was among first countries confronted rapid spread of in February, no real-time whole-genome tracking is performed country. To address this issue, we provided 50 sequences viral isolates ascertained from different geographical locations during March-July 2020. corresponding analysis on...
Background: Global real-time monitoring of SARS-CoV-2 variants is crucial to controlling the COVID-19 outbreak. The purpose this study was set up a Sanger-based platform for massive variant tracking in laboratories low-resource settings. Methods: We used nested RT-PCR assay, Sanger sequencing and lineage assignment 930-bp spike gene, which harbors specific concern (VOCs) mutations. our by comparing its results with whole genome (WGS) data on 137 positive samples. Then, we applied it 1028...
Background: The 'a' determinant domain of hepatitis B surface antigen (HBsAg) (positions 124 to 147) is recognized by antibodies raised either naturally or induced vaccine. Failure protect against virus (HBV) infection may occur due the conformational changes mutations. Objectives: present study analyzed molecular and three-dimensional (3D) characteristics HBsAg mutations among Iranian chronic (CHB) patients, who were vaccine drug naive. Methods: Eighty patients with positive test results...
Abstract Background: The objectives of this study were to analyze the clinical features and laboratory profiles risk factors associated with critical illness children SARS-CoV-2. Methods: 325 COVID-19 pediatric patients recruited through a collaborative research network between March May 2020. Demographics, clinical, laboratory, radiological results obtained from patient files. Results: Of patients, 189 (58%) 136 (42%) males females, respectively. mean age was 6.18 ± 4.99. 195 (60%) 130...
The prevalence of occult hepatitis B infection (OBI) among Iranian liver transplant recipient patients has not been explored yet. present study aimed to determine the OBI recipients.This encompassed 97 having undergone transplantation due several clinical backgrounds in Liver Transplantation Center, Tehran, Iran. After serological evaluation, two different types PCR methods were applied for amplification HBV DNA, followed by direct sequencing whole virus (HBV) surface genes.At time...
Abstract SARS-CoV-2 genome surveillance projects provide a good measure of transmission and monitor the circulating variants at regional global scales. Iran is one most affected countries still involved with virus in least five significant disease waves, as September 2021. Complete sequencing 50 viral isolates an early phase outbreak Iran, shed light on origins lineages that time. As part genomic program, we provided additional 319 complete genomes from October 2020 onwards. The current...
HBV Surface Ag mutations in chronic carriers are rare Baloochstan provinces of Iran: a community with low rate HBV-related cirrhosis and HCC
Background: Several studies have revealed that the hepatitis B virus (HBV) exists in peripheral blood mononuclear cells (PBMCs). It remains poorly understood whether HBV DNA and covalently closed circular (cccDNA) can emerge PBMCs of patients with different stages infection. Objectives: This study aimed to compare detection quantification presence cccDNA within PBMC from chronic (CHB), cirrhosis, hepatocellular carcinoma (HCC). Methods: The present was conducted on 120 participants (30 CHB...