A5004571272- Hearing, Cochlea, Tinnitus, Genetics
- Connexins and lens biology
- SARS-CoV-2 and COVID-19 Research
- Genetics and Neurodevelopmental Disorders
- Vestibular and auditory disorders
- Genomics and Rare Diseases
- COVID-19 epidemiological studies
- RNA regulation and disease
- Mitochondrial Function and Pathology
- SARS-CoV-2 detection and testing
- Nuclear Receptors and Signaling
- Chromatin Remodeling and Cancer
- Galectins and Cancer Biology
- Erythrocyte Function and Pathophysiology
- COVID-19 and Mental Health
- Animal Virus Infections Studies
- Genetic Associations and Epidemiology
- COVID-19 Pandemic Impacts
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- Forensic and Genetic Research
- Plant Virus Research Studies
- Ion channel regulation and function
University of Social Welfare and Rehabilitation Sciences
2020-2025
Abstract Coronary artery disease (CAD), the most prevalent cardiovascular disease, is leading cause of death worldwide. Heritable factors play a significant role in pathogenesis CAD. It has been proposed that approximately one‐third patients with CAD have positive family history, and individuals such history are at ~1.5‐fold increased risk their lifespans. Accordingly, long‐recognized familial clustering strong factor for this disease. Our study aimed to identify candidate genetic variants...
ABSTRACT Background Hereditary hearing loss (HHL) is a clinically and genetically heterogeneous sensorineural disorder that presents challenges for diagnosis. Next‐generation sequencing (NGS) approaches have facilitated more cost‐effective, streamlined diagnostic process. This study aimed to identify HHL variants using NGS in Iranian Azeri families Ardabil Province, establishing suitable framework screening programs tailored the local population. Methods Seventy‐four GJB2 ‐negative with from...
Complete SARS-CoV-2 genome sequencing in the early phase of outbreak Iran showed two independent viral entries. Subsequently, as part a surveillance project, we aimed to characterize genetic diversity over one year after emerging.We provided 319 whole-genome sequences used monitor circulating lineages March 2020-May 2021 time interval.The temporal dynamics major clades/lineages is comparable global perspective and represent 19A clade (B.4) dominating first disease wave, followed by 20A...
Genetic analysis of non-syndromic hearing loss (NSHL) has been challenged due to marked clinical and genetic heterogeneity. Today, advanced next-generation sequencing (NGS) technologies, such as exome (ES), have drastically increased the efficacy gene identification in heterogeneous Mendelian disorders. Here, we present utility ES re-evaluate phenotypic data for identifying candidate causal variants previously unexplained progressive moderate severe NSHL an extended Iranian family. Using...
Background: Intellectual disability (ID) is a genetically heterogeneous condition, and so far, 1679 human genes have been identified for this phenotype. Countries with high rate of parental consanguinity, such as Iran, provide an excellent opportunity to identify the remaining novel ID genes, especially those autosomal recessive (AR) mode inheritance. This study aimed investigate most prevalent via next-generation sequencing (NGS) in large cohort at Genetics Research Center (GRC) University...
Background: Recently, we have reported mutations in LARP7 gene, leading to neurodevelopmental disorders (NDDs), the most frequent cause of disability children with a broad phenotype spectrum and diverse genetic landscape. Methods: Here, present two Iranian patients from consanguineous families syndromic intellectual disability, facial dysmorphism, short stature. Results: Whole-exome sequencing (WES) revealed novel homozygous stop-gain (c.C925T, p.R309X) variant previously known acceptor...
Background: The study of Y-chromosomal variations provides valuable insights into male susceptibility in certain diseases like cardiovascular disease (CVD). In this study, we analyzed paternal lineage different Iranian ethnic groups, not only to identify developing medical etiology, but also pave the way for gender-specific targeted strategies and personalized medicine genetic research studies. Methods: diversity eleven groups was studied using 27 short tandem repeat (Y-STR) haplotypes from...
Hearing loss (HL) is the most prevalent sensorineural disorders, affecting about one in 1000 newborns. Over half of cases are attributed to genetic factors; however, due extensive clinical and heterogeneity, many remain without a conclusive diagnosis. The advent next-generation sequencing methodologies recent years has greatly helped unravel etiology HL by identifying numerous genes causative variants. Despite this, much remains be uncovered basis hearing (SNHL). Here, we report an Iranian...
After
Background: Global real-time monitoring of SARS-CoV-2 variants is crucial to controlling the COVID-19 outbreak. The purpose this study was set up a Sanger-based platform for massive variant tracking in laboratories low-resource settings. Methods: We used nested RT-PCR assay, Sanger sequencing and lineage assignment 930-bp spike gene, which harbors specific concern (VOCs) mutations. our by comparing its results with whole genome (WGS) data on 137 positive samples. Then, we applied it 1028...
Abstract SARS-CoV-2 genome surveillance projects provide a good measure of transmission and monitor the circulating variants at regional global scales. Iran is one most affected countries still involved with virus in least five significant disease waves, as September 2021. Complete sequencing 50 viral isolates an early phase outbreak Iran, shed light on origins lineages that time. As part genomic program, we provided additional 319 complete genomes from October 2020 onwards. The current...