A5035348887- T-cell and Retrovirus Studies
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Poxvirus research and outbreaks
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Transgenic Plants and Applications
- Circular RNAs in diseases
- Long-Term Effects of COVID-19
- COVID-19 impact on air quality
- MicroRNA in disease regulation
- Vaccine Coverage and Hesitancy
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Cytomegalovirus and herpesvirus research
- Bartonella species infections research
- Vibrio bacteria research studies
- Curcumin's Biomedical Applications
- Food Science and Nutritional Studies
- Soil and Land Suitability Analysis
Emory University
2023-2025
University of Bari Aldo Moro
2020-2025
Georgia State University
2025
Office of Infectious Diseases
2023
Shahid Sadoughi University of Medical Sciences and Health Services
2022
Tehran University of Medical Sciences
2020
Mashhad University of Medical Sciences
2017-2019
Shiraz University
2019
Zabol University
2017-2018
Since the onset of COVID-19 pandemic, various severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants have emerged. Although primary site SARS-CoV-2 infection is lungs, it can also affect brain and induce neurological symptoms. However, specific effects different on remain unclear. In this study, a whole-transcriptome analysis was conducted using tissues K18-hACE2 mice infected with ancestral B.1 (Wuhan) variant major concern, including B.1.1.7 (Alpha), B.1.351 (Beta),...
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon III (IFN-λ), which includes IL28, IL29, and IL28R, affects the outcome of viral infections, might be complicated in progression HAM/TSP. Here, we investigated host-virus interactions manifestation HAM/TSP, using IL28B, HTLV-1 Tax, basic leucine zipper factor (HBZ), proviral load (PVL). The study groups consisted...
Abstract Background Vector-borne diseases (VBDs) represent an emerging global threat to public health due the geographical expansion of arthropod vectors. The study aims assess seroprevalence selected vector-borne pathogens (VBPs) in different groups outdoor workers and occupational risk factors for exposure bites. Methods A cross-sectional was conducted on 170 recruited two regions southern Italy, including farmers, forestry workers, veterinarians, geologists/agronomists administrative...
Human T-cell leukemia virus type I (HTLV-1) belongs to the delta retrovirus family and etiological agent of adult (ATL(. While current HTLV-1 therapy, relies on using Zidovudine plus IFN-γ, there is no FDA approved drugs against it. In silico drug repurposing a fast accurate way for screening US-FDA find therapeutic option infection. So that, this research aims analyze dataset antiviral as potential prospect an anti-viral Molecular docking simulation was performed identify interactions with...
Land use planning aims to formulate activities, administer potential changes and prevent incompatible changes. The aim of this studyis prepare a land plan for Chabahar County, Iran, based on quantitative model using GIS. This study involves two main stages.First, the overlaying geographical maps preparing ecological capability different uses, like forestry, agriculture, rangemanagement, environmental conservation, ecotourism development villages, urban areas industry second stageinvolves...
Konjac glucomannan (KGM) is a water-soluble polysaccharide derived from the Amorphophallus's tuber and, as herbal medicine has shown, can suppress tumor growth or improve health. However, there been no investigation into effects of KGM on breast tumor-bearing mice. Therefore, in two cohort experiments, we assessed effect at daily doses 2 and 4 mg for 28 days dietary supplement also combination with lysate vaccine an adjuvant. Tumor volume was monitored twice weekly. In addition, TNF-α...
Human T-cell lymphotropic virus type 1 (HTLV-1) infection affects millions of individuals worldwide and can lead to severe leukemia, myelopathy/tropical spastic paraparesis, numerous other disorders. Pursuing a safe effective immunotherapeutic approach, we compared the viral polyprotein human proteome with sliding window approach in order identify oligopeptide sequences unique virus. The immunological relevance oligopeptides was assessed by searching them immune epitope database (IEDB). We...
Monkeypox is a zoonotic virus that has recently affected different countries worldwide. On July 23, 2022, the WHO declared outbreak of monkeypox as public health emergency international concern. Surveillance studies conducted in Central Africa 1980s and later during outbreaks same region showed smallpox vaccines to be clinically somewhat effective against virus. However, there no specific vaccine this This research used bioinformatics techniques establish novel multi-epitope candidate can...
Human T cell leukemia virus type-1 (HTLV-1) is the cause of adult leukemia/lymphoma (ATL), uveitis, and certain pulmonary diseases. In recent decades, many scientists have proposed development different treatment prevention strategies to combat HTLV-1 infection. this study, we used bioinformatics tools predict peptide protein vaccine candidates against that can potentially induce antibody production both CD4+ CD8+ immune responses. Five critical proteins, viz., Hbz, Tax, Pol, Gag, Env, were...
Background: Leukodystrophies constitute a heterogeneous group of inherited disorders primarily affecting the white matter central nervous system. Aminoacyl-tRNA synthetases (ARSs) catalyze attachment an amino acids to their cognate transfer RNAs (tRNAs). Pathogenic variants in both cytosolic and mitochondrial ARSs have been linked broad range neurological disorders, including hypomyelinating leukodystrophies pontocerebellar hypoplasias (PCH). Aminoacyl tRNA synthetase-interacting...
The human T-cell leukemia virus type 1 (HTLV-1) is a positive single-stranded RNA that belongs to the delta retrovirus family. As result, vaccine candidate can be recognized by B cells and T good for generating durable immune response. Further, GPEHT protein multi-epitope designed based on Gag, Pol, Env, Hbz, Tax proteins of HTLV-1. In developing suitable effective against HTLV-1, selection (GPEHT) with formulation an alum adjuvant was conducted. this study, we assessed potential stimulating...
Oral subunit vaccines are an interesting alternative strategy to traditional live-attenuated or inactivated for conferring protection against gut pathogens. Despite being safer and more cost-effective, the development of oral remains challenging due barriers imposed by gastrointestinal tract, such as digestive enzymes, a tolerogenic immune environment inability larger proteins cross epithelial barrier. Recent advances have focused on overcoming these using potent mucosal adjuvants...
Hepatitis C virus (HCV) infection is a major public health problem with about 1.75 million new HCV cases and 71 chronic infections worldwide. The study aimed to evaluate clinical, serological, molecular, liver markers develop mathematical predictive model for the quantification of viral load in infected patients. In this cross-sectional study, blood samples were taken from 249 recently diagnosed HCV-infected subjects tested condition, genotype, RNA load. Receiver operating characteristics...
Background: Today, due to the increased drug resistance, plants are used for treatment. The aim of this study was investigate effect ethanol extract Badrashbu (Dracocephalum moldavica) against strains antibiotic-resistant Escherichia coli and Klebsiella pneumonia. Methods: plant extracts were prepared using a rotary device. pneumonia isolated from nosocomial infection patients at hospitals Zabol. MIC MBC in different concentrations bacteria determined by disk diffusion method. Results:...