A5042121555- Selenium in Biological Systems
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Cancer Research and Treatments
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Digestive system and related health
- Protein Hydrolysis and Bioactive Peptides
- Phytochemistry and biological activity of medicinal plants
- Medical and Biological Ozone Research
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Antimicrobial Resistance in Staphylococcus
- Trace Elements in Health
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Polysaccharides and Plant Cell Walls
- Pregnancy and Medication Impact
- Moringa oleifera research and applications
- Nanoparticle-Based Drug Delivery
- Bee Products Chemical Analysis
- Curcumin's Biomedical Applications
- Heavy Metal Exposure and Toxicity
- 3D Printing in Biomedical Research
Tehran University of Medical Sciences
2016-2025
Biotechnology Research Center
2016-2025
Lorestan University of Medical Sciences
2024
Pasteur Institute of Iran
2015-2016
The immunomodulatory effects of lactic acid bacteria have been demonstrated previously. In this study, a Lactobacillus plantarum strain was selected and enriched with selenium nanoparticles for use as new immunomodulating agent in breast cancer murine model. 30 female inbred BALB/c mice were equally divided into test group control group. For 2 weeks prior to tumor induction, each mouse received daily oral administration 2.5×108 CFU/ml L. (SeNPs), then 1×106 4T1 cells injected subcutaneously....
Background: Streptococcus mutans is a major component of dental plaque, contributing to cariogenic biofilm formation and inducing caries. Attempts have recently been made use postbiotic mediators (PMs) prevent This research evaluated the antimicrobial/antibiofilm activity PMs derived from Lactobacillus rhamnosus GG (LGG) reuteri (LR) against S. in vitro. Methods: were obtained Lactobacilli supernatants. The minimum inhibitory concentration, bactericidal antibiofilm potential, metabolic using...
Lactic acid bacteria can affect the maturation of immune cells and their products not only in gut but also on systemic organs such as lymph nodes spleen. In present work, we studied effects oral administration Lactobacillus acidophilus responses BALB/c mice bearing transplanted breast tumour. Two groups female inbred mice, each containing nine test control, were used. The L. ATCC4356 strain was inoculated DeMan–Rogosa–Sharpe broth cultivated for 24 h at 37°C. Then, it collected by...
The immunomodulative effects of Lactic Acid Bacteria as probiotics have been already demonstrated.The current study aimed to evaluate the effect oral administration Lactobacillus acidophilus on immune responses and patterns cytokine production in BALB/c mice bearing breast cancer.The used thirty inbred mice, six- eight-week-old; they were divided into two groups 15 each. One group was control each assay. L. (ATCC4356) inoculated MRS broth cultivated overnight at 37°C under anaerobic...
Hepatitis B virus (HBV) infection is known as a life-threatening liver and leads to chronic disease if left untreated. Nevertheless, the prevalence of HBV has been reduced by an approved vaccination approach using recombinant surface Antigen (HBsAg) Alum, vaccine. Alum can be used adjuvant increase HBsAg immunogenicity strong Th2 stimulator. There vital need stimulate Th1 immunity vaccination; however, present vaccine does not induce prophylactic immune response in some groups. The main aim...
Organoids as self-organized structure derived from stem cells can recapitulate the function of an organ in miniature form which have developed great potential for clinical translation, drug screening and personalized medicine. Nevertheless, majority patient-derived organoids (PDOs) are currently being cultured basement membrane matrices (BMMs), constrained by xenogeneic origin, batch-to-batch variability, cost, complexity. Besides, organoid culture relies on biochemical signals provided...
Tumor associated antigens can be viably used to enhance host immune response.The immunomodulatory effect of biogenic selenium nanoparticles (SeNPs) was compared between treated and untreated mice with crude 4T1 cells.Female inbred BALB/c (60) were injected by cancinogenic cells causing breast cancer. After 10 days, all tumor bearing divided into 4 groups. Group 1 daily provided oral PBS the same buffer after induction considered as control. 2 received only 100 μg/day SeNPs an supplement for...
The modification of tumor-associated antigen-based vaccine to elicit a more robust immune response has been addressed in several ways. In the present work, we aimed investigate immunomodulatory effect selenium nanoparticles as an immunoadjuvant formulation preventive form. Fortyfive female inbred BALB/c mice five-to-seven weeks old were used and divided into three groups test control, each containing fifteen mice. Group one injected by PBS control. two breast tumor cell lysate alone vaccine....