A5020612267- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Liver Disease Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Protein Structure and Dynamics
- Viral Infectious Diseases and Gene Expression in Insects
- Wnt/β-catenin signaling in development and cancer
- Synthesis and Biological Evaluation
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Nanowire Synthesis and Applications
- Cancer-related gene regulation
- Quinazolinone synthesis and applications
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
Heidelberg University
2021-2024
German Cancer Research Center
2021-2024
University of Calgary
2023-2024
Institute of Cancer Research
2023
München Klinik Schwabing
2022
Technical University of Munich
2022
Iran University of Medical Sciences
2021
Karolinska Institutet
2020
Tehran University of Medical Sciences
2016-2019
Pasteur Institute of Iran
2017-2019
Abstract B cell maturation antigen (BCMA) target loss is considered to be a rare event that mediates multiple myeloma (MM) resistance anti-BCMA chimeric receptor T (CAR T) or bispecific engager (TCE) therapies. Emerging data report downregulation of G-protein-coupled family C group 5 member D (GPRC5D) protein often occurs at relapse after anti-GPRC5D CAR therapy. To examine the tumor-intrinsic factors promote MM escape, we performed combined bulk and single-cell whole-genome sequencing copy...
Adoptive T cell therapy is a promising for multiple myeloma (MM), but its efficacy hinges on understanding relevant biological and predictive markers of response. B maturation antigen (BCMA) key target in MM, with active development anti-BCMA engagers (TCE) chimeric receptor (CAR T) therapies. The regulation surface BCMA expression by MM cells, resulting the shedding soluble (sBCMA), has triggered debate surrounding significance sBCMA as marker potential impact treatment outcomes. In order...
The translocation t(11;14) occurs in 20% of patients with multiple myeloma (MM) and results the upregulation CCND1. Nearly two-thirds MM cells are BCL2 primed highly responsive to oral inhibitor venetoclax. Although it is evident that this unique sensitivity venetoclax depends on Bcl-2 homology domain 3- proapoptotic protein priming BCL2, biology underlying dependency poorly defined. Importantly, epigenetic regulation transcriptomes its impact gene clinical response remain elusive. In study,...
The interplay between H2 S and nitric oxide (NO) is thought to contribute renal functions. current study was designed assess the role of NO in mediating renoprotective effects hydrogen sulfide 5/6 nephrectomy (5/6 Nx) animal model. Forty rats were randomly assigned 5 experimental groups: (a) Sham; (b) Nx; (c) 5/6Nx+sodium hydrosulfide-a donor H 2 S, (5/6Nx+sodium hydrosulfide [NaHS]); (d) 5/6Nx+NaHS+ L-NAME (a nonspecific synthase [NOS] inhibitor); (e) 5/6Nx+NaHS+aminoguanidine selective...
Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers non-infected individuals, which has been attributed cross-reactive CD4 memory cells from previous exposure seasonal coronaviruses. Less CD8 documented date.We used the NetCTLPan neural network Epitope Database and Analysis Resource select a series 27 HLA-A*02:01 epitopes derived proteome SARS-CoV-2. Their binding capacity was assessed by...
Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in major hydrophilic region (MHR) of surface antigen (HBsAg) protein. It now well established that common G145R mutation highly capable escaping from HBsAg immune recognition. However, impacts this on structure and immunogenic activity have been poorly investigated.The present study analyzed effects HBsAg.Three-dimensional (3D) for both wild-type mutant were predicted refined using...
Occult hepatitis B infection (OBI) is a frequent finding in human immunodeficiency virus (HIV)-infected patients. While several related mutations the (HBV) genome have been reported, their distinct impact on HBsAg synthesis largely obscure.Thirty-one (18%) out of 172 HIV-infected patients, who were selected from HBsAg-negative positive for HBV-DNA assigned as being OBI-positive. We generated series expression constructs variant with "a" determinant amino acid substitutions including P127L,...
Dysregulated Wnt signaling pathway is highly associated with the pathogenesis of several human cancers. Dickkopf proteins (DKKs) are thought to inhibit through binding lipoprotein receptor-related protein (LRP) 5/6. In this study, based on 3-dimensional (3D) structure DKK3 Cys-rich domain 2 (CRD2), we have designed and developed peptide inhibitors pathway. Modeller 9.15 package was used predict 3D CRD2 Homology modeling (HM) protocol. After refinement minimization GalaxyRefine NOMAD-REF...
Hepatitis C virus (HCV) has been known as a major cause of hepatocellular carcinoma (HCC) worldwide. However, the distinct molecular mechanisms underlying effects HCV proteins on HCC progression have remained unclear.In present study, we studied possible role in initiation and invasion using topological analysis protein-protein interaction (PPI) networks.After with GEO2R, PPI network differentially expressed genes (DEGs) was constructed for both chronic samples. The STRING GeneMANIA...
Recent studies have shown that the high mortality of patients with colorectal cancer (CRC) is related to its ability spread surrounding tissues, thus there a need for designing and developing new drugs.Here, we proposed combinational therapy strategy, an inhibitory peptide in combination miRNA targeting, modulating CRC metastasis. In this study, some recent patents were also reviewed.After data analysis GEO2R gene annotation using DAVID server, regulatory interactions differentially...