A5091909197- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Hepatitis Viruses Studies and Epidemiology
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
Tehran University of Medical Sciences
2016
Occult hepatitis B infection (OBI) is a frequent finding in human immunodeficiency virus (HIV)-infected patients. While several related mutations the (HBV) genome have been reported, their distinct impact on HBsAg synthesis largely obscure.Thirty-one (18%) out of 172 HIV-infected patients, who were selected from HBsAg-negative positive for HBV-DNA assigned as being OBI-positive. We generated series expression constructs variant with "a" determinant amino acid substitutions including P127L,...
Finding the predominant circulating subtype of human immunodeficiency virus type 1 (HIV-1) and surveying co-infection with other infectious viruses are crucial to making preventive decisions. To this end, 50 Iranian HIV-positive patients made up 37 men 13 women were selected. Most (70%) intravenous drug users (IDUs), 48 32% co-infected HCV HBV, respectively. The rate simultaneous infection HIV, HCV, HBV was found be 6%. p17 region gag c2-v5 env genes sequenced then clustered by phylogenetic...
Aim: The aims of this study were to find out the prevalence occult hepatitis B infection (OBI) in HIV-1 patients, as well analyze mutational patterns OBI-positive individuals. Materials & methods: 172 HBsAg-negative, HIV-1-positive patients selected according data extracted from questionnaires. HBV serologic and molecular assays performed. An extensive analysis was applied using direct sequencing on HBsAg. Results: Thirty-one samples (18%) OBI positive. Among 24 available samples, 17 (71%)...