A5020993069- CAR-T cell therapy research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Nanowire Synthesis and Applications
- Cancer-related Molecular Pathways
- vaccines and immunoinformatics approaches
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Mesenchymal stem cell research
- PARP inhibition in cancer therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
- Hedgehog Signaling Pathway Studies
- Advanced biosensing and bioanalysis techniques
- Periodontal Regeneration and Treatments
- Lymphoma Diagnosis and Treatment
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Cancer therapeutics and mechanisms
Helmholtz Institute Mainz
2023
Johannes Gutenberg University Mainz
2023
Heidelberg University
2019-2022
German Cancer Research Center
2019-2022
Pasteur Institute of Iran
2017-2021
Biotechnology Research Center
2021
National Center for Tumor Diseases
2019
Tehran University of Medical Sciences
2016
Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers non-infected individuals, which has been attributed cross-reactive CD4 memory cells from previous exposure seasonal coronaviruses. Less CD8 documented date.We used the NetCTLPan neural network Epitope Database and Analysis Resource select a series 27 HLA-A*02:01 epitopes derived proteome SARS-CoV-2. Their binding capacity was assessed by...
Colorectal cancer (CRC) is the third most prevalent all around world. Chemotherapy plays an essential role in treatment of CRC while Oxaliplatin, Irinotecan, and 5 – fluorouracil (5-FU) are commonly used chemotherapeutic drugs. However, chemo-resistance a major obstacle to successful therapy. It has been shown that inhibition Wnt signaling pathway can sensitize cells chemotherapy. Lymphoid enhancer factor (LEF1) member TCF/LEF transcription family mediating nuclear responses. The long...
Here, we describe the identification of two T-cell receptors (TRs) containing TRDV genes in their TRA chains, first one human and second mouse. First, using 5’RACE on a mixed lymphocyte-tumor cell culture (MLTC), identified TRDV1 5’-untranslated region (UTR) complete coding sequence rearranged productively to TRAJ24. Single-cell TR RNA sequencing (RNA-seq) MLTC, conducted identify additional clonotypes, revealed that analysis software detected hybrid TRDV-TRAJ (TRA) chain but excluded it...
Niche is an important microenvironment regulating stem cell's natural behavior and its fate.Mesenchymal Stem Cells (MSCs) are the most common cells used in bone tissue engineering.However, culture procedures do not retain MSCs their niche apply vitro expansion which can cause abnormal behavior.In this study, we propose that, by Keeping native niche, of these interactions maintained quality differentiation will enhance.In our previous studies, isolated kept niche-like environment...
Abstract In human tumor models we tried to identify and clone the TCR of tumor-reactive T cells enriched in mixed lymphocyte tumor-cell cultures (MLTC). a particular MLTC, identified predominant beta chain using Beta Mark Vbeta Kit, but corresponding alpha could not be amplified via RT-PCR TRAV -specific forward primers. Therefore, applied 5’RACE obtain sequences. The product revealed an that encompassed 89bp TRDV1 5’UTR, followed by coding sequence joined frame TRAJ24 . ORF reaching from...
Abstract Wnt signaling pathway is assumed to be the most important activated in colorectal cancer. As this addition Notch and hedgehog responsible for maintenance of stem cells population cancerous cells, it could predicted that by silencing resistance chemotherapeutic drugs would decreased. In regard we tried silence LEF1 as an component two cancer cell lines see response transfected 5-flurouracil. Oligonucleotide was constructed inserted into pSilencer Neo2.1 (Invitrogen). Thereafter these...