A5079324379- Inflammatory Bowel Disease
- Microscopic Colitis
- Vitamin D Research Studies
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Energy and Environment Impacts
- Therapeutic Uses of Natural Elements
- Primary Care and Health Outcomes
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Pregnancy and Medication Impact
- Diverticular Disease and Complications
- Diagnosis and treatment of tuberculosis
- Air Quality and Health Impacts
- Mycobacterium research and diagnosis
- Climate Change and Health Impacts
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
University Medical Center Utrecht
2016-2019
Collaborative Group (United States)
2016
Smoking has a negative impact on Crohn's disease (CD), but the mechanisms underlying this association are unclear. We compared gut microbiota composition of smoking with nonsmoking patients CD using metagenomic approach. Stool samples and clinical data were collected from current smokers nonsmokers France Netherlands, matched for country, gender, age, activity, body mass index. Fecal DNA was sequenced an Illumina HiSeq 2500. On average, 40 million paired-end reads generated per sample. Gene...
Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between Crohn's [CD] ulcerative colitis [UC] in a large European population. In total, 401326 participants, aged 20–80 years, were recruited eight countries Europe 1991 1998. At baseline, [total fibres, fibres from fruit, vegetables cereals] recorded using food frequency questionnaires. The monitored for disease. Each...
Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated association between prediagnostic intake these foods dietary calcium, subsequent development Crohn's (CD) ulcerative colitis (UC). In total, 401,326 participants were enrolled European Prospective Investigation into Cancer Nutrition cohort. At recruitment, consumption...
Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). We investigated association between air pollution exposure and IBD. The European Prospective Investigation into Cancer Nutrition cohort was used identify cases with Crohn's (CD) (n = 38) ulcerative colitis (UC) 104) controls 568) from Denmark, France, Netherlands, UK, matched for center, gender, age, date recruitment. Air data were obtained Study Cohorts Pollution Effects. Residential assessed land-use...
Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. A total 401,326 men women aged 20 to 80 years from 8 countries were recruited between 1991 1998 at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on content 502 polyphenols. Incident cases Crohn's diseases...
A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated association between prediagnostic circulating concentrations and dietary intakes D, Crohn's (CD) ulcerative colitis (UC). Among 359,728 participants European Prospective Investigation into Cancer Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age,...
Various treatments are available for the palliation of esophageal cancer, but optimal therapeutic approach is unclear. This study aimed to assess palliative treatment modalities used in patients with inoperable cancer and identify factors associated decisions. A population-based, retrospective cohort was conducted using data from nationwide Netherlands Cancer Registry medical records seven participating hospitals. Patients diagnosed stage III–IV or gastric cardia central part between 2001...
Abstract Background The goal of this study was to determine long-term mortality and causes death in patients after hospitalization for inflammatory bowel disease (IBD). Methods A cohort admitted the hospital because IBD first time between 1998 2010 identified by linkage nationwide Dutch registries. Mortality risks Crohn’s (CD) ulcerative colitis (UC) were compared with a large random sample individuals from general population. Multivariable Cox regression models used calculate hazard ratios...
Background: A causal link between a low vitamin D status and the development of inflammatory bowel disease (IBD) has previously been suggested. The aim this study was to investigate association prediagnostic circulating concentrations dietary intakes D, risk Crohn's (CD) ulcerative colitis (UC). Methods: Among 359,728 participants European Prospective Investigation into Cancer Nutrition cohort, individuals who developed CD or UC after enrolment were identified. Each case matched with two...
Background: The aims of this study were to determine the incidence hospitalization for inflammatory bowel disease (IBD) and outcomes after hospital admission. Methods: A cohort patients who admitted because IBD first time between 1995 2010 was identified by linkage nationwide Dutch registries. Incidence rates, mortality risks causes death Crohn's (CD) ulcerative colitis (UC) assessed. Cox regression models used differences CD UC. Results: total 28,843 individuals (56.0% men, mean age 47.7...
Ileocaecal resection is the most commonly performed operation for Crohn’s disease (CD), but it presently unclear if this affects gut microbiome. This study aims to compare microbiota composition between CD patients with and without an ileocaecal resection. Stool samples clinical data were collected from 30 ileal in remission a history of previous bowel surgery (control group), matched gender age. The faecal was characterised by 16S ribosomal RNA sequencing. Microbial diversity assessed using...