A5033239874- Gut microbiota and health
- Sepsis Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Thermal Regulation in Medicine
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Pediatric Pain Management Techniques
- Burn Injury Management and Outcomes
- Nosocomial Infections in ICU
- Parkinson's Disease Mechanisms and Treatments
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Bacterial Identification and Susceptibility Testing
- Vitamin C and Antioxidants Research
- Microscopic Colitis
- Body Contouring and Surgery
- Dysphagia Assessment and Management
- Heart Failure Treatment and Management
- Metabolomics and Mass Spectrometry Studies
Digital Research Alliance of Canada
2022
Alliance Data (United States)
2022
Enterome (France)
2016-2021
Roche (France)
2021
Hospices Civils de Lyon
2014-2017
bioMérieux (France)
2014-2017
Hôpital Edouard Herriot
2017
Université Claude Bernard Lyon 1
2017
Laboratoire de Chimie
2015
HCL Technologies (India)
2014
Severe septic syndromes deeply impair innate and adaptive immunity are responsible for sepsis-induced immunosuppression. Although neutrophils represent the first line of defense against infection, little is known about their phenotype functions a few days after sepsis, when immunosuppressive phase maximal (i.e., between d 3 8). The objective present study was to perform, time, global evaluation neutrophil alterations in immunosuppressed patients (at 3–4 6–8) using phenotypic functional...
Smoking has a negative impact on Crohn's disease (CD), but the mechanisms underlying this association are unclear. We compared gut microbiota composition of smoking with nonsmoking patients CD using metagenomic approach. Stool samples and clinical data were collected from current smokers nonsmokers France Netherlands, matched for country, gender, age, activity, body mass index. Fecal DNA was sequenced an Illumina HiSeq 2500. On average, 40 million paired-end reads generated per sample. Gene...
BackgroundBariatric surgery is an effective therapeutic procedure for morbidly obese patients. The 2 most common interventions are sleeve gastrectomy (SG) and laparoscopic Roux-en-Y gastric bypass (LRYGB).ObjectivesThe aim of this study was to compare microbiome long-term after SG LRYGB in patients.SettingUniversity Hospital, France; University United States; Switzerland.MethodsEighty-nine 108 patients who underwent LRYGB, respectively, were recruited. Stools collected before 6 months...
The gut-brain axis may play a central role in the pathogenesis of neurological disorders. Dozens case-control studies have been carried out to identify bacterial markers by use targeted metagenomics. Alterations several taxonomic profiles confirmed across populations, however, no consensus has made regarding alpha-diversity. A recent publication described and validated novel method based on richness evenness measures gut microbiome order reduce complexity multiplicity alpha-diversity...
Abstract Background An Escherichia coli ( E. ) pathotype with invasive properties, first reported by Darfeuille-Michaud and termed adherent-invasive (AIEC), was shown to be prevalent in up half the individuals Crohn’s Disease (CD), suggesting that these bacteria could involved pathophysiology of CD. Among genes related AIEC pathogenicity, fim has potential generate an inflammatory reaction from intestinal epithelial cells macrophages, as it interacts TLR4, inducing production cytokines...
The aim of this study was to assess the effect low-dose corticosteroid therapy in reducing shock duration after severe burn.A placebo-controlled, double-blind, randomized clinical trial (RCT) performed on two parallel groups burn intensive care unit (ICU). Patients were receive either or placebo for seven days. A corticotropin test at time randomization, before administration treatment dose. Thirty-two severely burned patients with refractory (>0.5 μg/kg/min norepinephrine) prospectively...
We consider the problem of incorporating evolutionary information (e.g., taxonomic or phylogenic trees) in context metagenomics differential analysis. Recent results published literature propose different ways to leverage tree structure increase detection rate differentially abundant taxa. Here, we instead use a hierarchical structure, form correlation-based tree, as it may capture data better than phylogeny. first show that correlation and phylogeny are significantly before turning impact...
Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed impact of on transcriptional response and we are lacking data burn shock. Our objective was assess hydrocortisone-induced modulation severe particularly response. We collected whole blood samples during a randomized controlled trial assessing efficacy Using genome microarrays, first compared patients (n = 32) from placebo group...
Abstract Background Bariatric surgery is an effective therapeutic procedure for morbidly obese patients as it induces sustained weight loss. The two most common interventions are Laparoscopic Sleeve Gastrectomy (LSG) and Roux-en-Y Gastric Bypass (LRYGB). Objective Characterizing the gut microbiota changes induced by LSG LRYGB. Design 89 108 who underwent LRYGB respectively, were recruited from three countries: USA, France Switzerland. Stools collected before 6 months after surgery. Microbial...
BACKGROUND & AIMS Early reports suggest that both fecal shedding and dysbiosis of the gut microbiome are associated to disease severity in COVID-19 patients. We investigated as well prevalence SARS-CoV-2 stool samples from two French populations: exposed healthcare workers elderly hospitalized The predictive power bacterial loss diversity detection was assessed at 4 weeks against clinical outcomes patient group. METHODS 79 contact with patients 64 hospitalised a unit France were included...
The systemic effect of inflammatory mediators release after severe burn is a cardiovascular dysfunction called shock. Patients need vasopressor infusion to maintain adequate delivery oxygen but it could have deleterious effects on skin perfusion and worsen the depth. This shock result from interplay initial hypovolemia multiple mediators. It has been shown that low-dose hydrocortisone reduce duration mechanisms involved remain unclear. In this study, we investigated genomic response injuries...
The systemic effect of inflammatory mediators released after severe burn is a cardiovascular dysfunction called shock. Patients need vasopressor infusion to maintain adequate delivery oxygen but it could have deleterious effects on skin perfusion and worsen the depth. This shock result from interplay initial hypovolemia release multiple [1]. It has been shown that low-dose hydrocortisone reduce duration mechanisms involved remain unclear. We investigated genomic response injuries determine...
Abstract We consider the problem of incorporating evolutionary information (e.g. taxonomic or phylogenic trees) in context metagenomics differential analysis. Recent results published literature propose different ways to leverage tree structure increase detection rate differentially abundant taxa. Here, we instead use a hierachical structure, form correlation-based tree, as it may capture data better than phylogeny. first show that correlation and phylogeny are significantly before turning...