A5091449450- Dementia and Cognitive Impairment Research
- HIV Research and Treatment
- Autism Spectrum Disorder Research
- HIV-related health complications and treatments
- Pharmaceutical Practices and Patient Outcomes
- Schizophrenia research and treatment
- Inhalation and Respiratory Drug Delivery
- HIV/AIDS Research and Interventions
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Venous Thromboembolism Diagnosis and Management
- Bariatric Surgery and Outcomes
- Digital Mental Health Interventions
- Pharmaceutical studies and practices
- Poisoning and overdose treatments
- Attention Deficit Hyperactivity Disorder
- Nuclear Structure and Function
- Lipid Membrane Structure and Behavior
- Cognitive Functions and Memory
- COVID-19 and Mental Health
- BRCA gene mutations in cancer
- Genomics and Chromatin Dynamics
- Peripheral Artery Disease Management
- Health, Medicine and Society
- Physical Activity and Health
Centre Hospitalier Universitaire de Nice
2016-2025
Université Côte d'Azur
2017-2025
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2023-2024
Santé Publique France
2023
Institut thématique Santé Publique
2017-2023
Cognition Behaviour Technology
2018-2023
Institut de Chimie de Nice
2023
Laboratoire Motricité Humaine Éducation Sport Santé
2018-2022
Scientific Centre of Monaco
2022
Institut de Biologie Valrose
2019-2021
Although bariatric surgery is effective against morbid obesity, the association of this with risk colorectal cancer remains controversial.To assess whether associated altered among individuals obesity.This retrospective, population-based, multicenter, cohort study based on French electronic health data included 1 045 348 aged 50 to 75 years, and free at baseline. All inpatients obesity having recorded during a hospital stay between 2009 2018 by national insurance information system database...
Cognitive and behavioral symptoms are the clinical hallmarks of neurocognitive disorders. training may be offered to reduce risks cognitive decline dementia symptoms, such as apathy. Information communication technology approaches, including serious games, can useful in improving playful aspect computerized providing motivating solutions elderly patients.The objective this study was assess effectiveness employing MeMo (Memory Motivation) Web app with regard patients disorders.MeMo is a that...
Gender distribution varies across neurodegenerative disorders, with, traditionally, a higher female frequency reported in Alzheimer's disease (AD) and male Parkinson's (PD). Conflicting results on gender are concerning dementia with Lewy bodies (DLB), usually considered as an intermediate between AD PD. The aim of the present study was to investigate differences DLB French specialized memory settings using data from national database spanning 2010 2015 compare sex ratio that AD, (PDD), Our...
Work difficulties are a primary issue of multiple sclerosis (MS). This is because disease onset usually occurs during time when establishing career and employment paramount importance. The MSWDQ-23 (Multiple Sclerosis Difficulties Questionnaire) was developed to assess work in MS. WORKSEP project aimed adapt validate the French develop cutoff scores through multicentric study 14 centers across France. Two hundred six persons with MS were recruited: 149 relapsing-remitting 57 progressive...
Nuclear shape is different in stem cells and differentiated reflects important changes the mechanics of nuclear envelope (NE). The current framework emphasizes key role lamina its alterations disease. Whether active stress controls deformations how this interplays with properties NE to control dynamics unclear. We address early Drosophila embryo, which profound parallel transcriptional activation zygotic genome. show that microtubule (MT) polymerization events produce elementary forces...
To assess the impact of BRCA1/2 test results on carriers' reproductive decision-making and factors determining their theoretical intentions about preimplantation genetic diagnosis (PGD) prenatal (PND).Unaffected mutation carriers childbearing age (N = 605; 449 women; 151 men) were included at least 1 year after disclosure in a cross-sectional survey nested national cohort. Multivariate adjustment was performed data obtained self-administered questionnaires.Response rate 81.0%. Overall, 32.5%...
Abstract Introduction The aim of this study was to evaluate the efficacy a serious exergame in improving neuropsychiatric symptoms patients with neurocognitive disorders. Methods X‐Torp is combining motor and cognitive activities. Ninety‐one subjects (mean age = 81.7 years, mean Mini‐Mental State Examination 18.3) were recruited 16 centers. Centers randomized into intervention control Subjects underwent assessment for behavioral at baseline (BL), end (W12), 12 weeks after (W24). Results...
Abstract Background The primary progressive aphasia (PPA) diagnosis trajectory is debated, as several changes in occur during PPA course, due to phenotype evolution from isolated language alterations global cognitive impairment. goal of the present study, based on a French cohort, was describe demographics and subjects with comparison Alzheimer’s disease (AD) period 7 years. Methods We conducted repeated cross-sectional study. study population comprised individuals AD ( N =167,191) 2010 2016...
Abstract Objective To evaluate taste disorders after middle ear surgery, their modifying factors especially chorda tympani nerve injury or underlying otologic disease. We investigated consequences of on quality life. Study Design Prospective cohort study. Setting Monocentric study in tertiary care center. Methods A total 214 patients who underwent surgery were included. Data regarding collected by questionnaires over a 1‐year follow‐up period. Results Taste reported 42.7% at 10 days, 23.3% 4...
Supported lipid bilayers that can fully represent biological cell membranes are attractive biomimetic models for biophysical and biomedical applications. In this study, we develop a new approach to engineering stable supported demonstrate their utility the study of protein−membrane interactions. This system uses zirconium phosphonate monolayer modify substrate generate reactive surface tethers membrane via highly covalent bond between ions divalent phosphate groups in assembly, example, from...
Objectives Inversion of the CD4:CD8 ratio is a marker immune activation and age‐associated disease. We measured as cognitive impairment in HIV ‐infected patients explored differences according to clinical severity. Methods Post hoc analysis data from two prospective cohorts randomly selected undergo neuropsychological tests was performed. Test scores were adjusted for age, gender education. Inclusion criteria undetectable viral load stable treatment at least 6 months. Subjects with...
Two bisphosphonate adaptors were designed to immobilize histidine-tagged proteins onto glass substrates coated with a zirconium phosphonate monolayer, allowing efficient and oriented immobilization of capture proteins, affitins directed lysozyme, on microarray format. These bifunctional contain two phosphonic acid anchors at one extremity either nitrilotriacetic (NTA) or NTA groups the other. The provide stable bond interface by multipoint attachment allow high density surface coverage...
Objective: Affective disorders are frequently encountered among elderly populations, and the use of information communication technologies (ICT) could provide an added value for their recognition assessment in addition to current clinical methods. The diversity lack consensus emerging field ICTs is however a strong limitation global daily practice. aim present article recommendations management affective populations with or without dementia. Methods: A Delphi panel was organized gather from...
Background: Neuropsychological tests are particularly important for the clinical evaluation and Alzheimer’s disease (AD) diagnosis. However, currently employed neuropsychological assessment have been developed several decades ago, thus they do not fully exploit potential provided by modern digital tools. One of most commonly to assess attention executive functions is Trail Making Test (TMT). Objective: The aim this study was evaluate whether TMT used serious exergame X-Torp (TMT X- Torp )...