A5073771304- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Microbial Inactivation Methods
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Microscopic Colitis
- Inflammatory Bowel Disease
- Surgical Simulation and Training
- Simulation-Based Education in Healthcare
- Anorectal Disease Treatments and Outcomes
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- DNA Repair Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Toxin Mechanisms and Immunotoxins
- Cardiac, Anesthesia and Surgical Outcomes
- Appendicitis Diagnosis and Management
- Celiac Disease Research and Management
- Microfluidic and Bio-sensing Technologies
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Electrolyte and hormonal disorders
- Plant tissue culture and regeneration
Radboud University Nijmegen
2023-2025
Radboud University Medical Center
2023-2025
University Medical Center
2024
University of Amsterdam
2020
Amsterdam University Medical Centers
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013-2018
Imperial College London
2009
The Netherlands Cancer Institute
2004
Purpose To (a) investigate the safety of percutaneous irreversible electroporation (IRE) for locally advanced pancreatic cancer and (b) evaluate quality life (QOL), pain perception, efficacy in terms time to local progression, event-free survival, overall survival (OS). Materials Methods The study was approved by review board (NL42888.029.13). All patients provided written informed consent participation, ablation procedure, data usage. Between January 2014 June 2015, 25 with histologically...
Acute pancreatitis is mostly caused by gallstones or sludge. Early decompression of the biliary tree endoscopic retrograde cholangiography (ERC) with sphincterotomy may improve outcome in these patients. Whereas current guidelines recommend early ERC patients concomitant cholangitis, not recommended mild pancreatitis. Evidence on role routine without cholangitis but at high risk for complications lacking. We hypothesize that improves The APEC trial a randomized controlled, parallel group,...
To assess specific imaging characteristics after irreversible electroporation (IRE) for locally advanced pancreatic carcinoma (LAPC) with contrast-enhanced (ce)MRI and ceCT, to explore the correlation of these development recurrence. Qualitative quantitative analyses data were performed on 25 patients treated percutaneous IRE LAPC. Imaging ablation zone ceCT ceMRI assessed over a 6-month follow-up period. Contrast ratio scores between pre- post-treatment compared. detect early markers...
de Jong, Mike JP. MD; van Aard, Roel CM. BSc; Kuipers, Romy N. te Morsche, René HM. Delft, Foke MD, FEBGH; Siersema, Peter D. PhD; on behalf of the Dutch Pancreatitis Study Group Author Information
Pancreatic ductal adenocarcinoma (PDAC) still has a dismal 5-year overall survival of 13 %. Chemotherapy is increasingly used as treatment in both (neo-) adjuvant and palliative conditions. However, the benefits chemotherapy must be weighed against significant side effects leading to reduction quality life. CE-EUS elastography could provide additional information about vascularization elasticity pancreatic tumor. The aim this study was investigate if contrast-enhanced endoscopic ultrasound...
Background and study aims: Percutaneous transhepatic biliary drainage (PTBD) endoscopic ultrasound guided (EUS-BD), including choledochoduodenostomy (EUS-CDS) are alternative methods for in patients with distal malignant obstruction (MBO) after failed Endoscopic Retrograde CholangioPancreatography (ERCP). Data on long-term outcomes, adverse events (AEs), quality of life (QoL) EUS-CDS PTBD limited. Therefore, we created a registry to evaluate the outcomes both procedures. Methods Patients MBO...
Data on the incidence and clinical relevance of gallstones in patients with suspected acute alcoholic pancreatitis are lacking essential to minimize risk recurrent pancreatitis. The aim this study was assess associated rate presumed
Introduction The majority of patients with perihilar cholangiocarcinoma (PHC) has locally advanced disease or distant lymph node metastases on presentation exploratory laparotomy, which makes them not eligible for resection. As the prognosis PHC in palliative setting is significantly better compared organ metastases, ablative therapies may be beneficial. Unfortunately, current options are limited. Photodynamic therapy causes skin phototoxicity and thermal methods, such as stereotactic body...
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common complication of ERCP and may run a severe course. Evidence suggests that vigorous periprocedural hydration can prevent PEP, but studies to date have significant methodological drawbacks. Importantly, evidence for its added value in patients already receiving prophylactic rectal non-steroidal anti-inflammatory drugs (NSAIDs) lacking cost-effectiveness approach has not been investigated. We...
Abstract Phase I and II clinical trails are currently investigating the antitumor activity of cisplatin camptothecins (CPTs; DNA topoisomerase poisons), based on dramatic synergistic cytotoxicity these agents in some preclinical models. However, mechanistic basis for this synergism is poorly understood. By exploiting evolutionary conservation repair pathways from genetically tractable organisms such as budding fission yeasts to mammalian cells, we demonstrate that CPT requires homologous...
Aims Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) with lumen-apposing metal stents (LAMS) may be used in patients a distal malignant biliary obstruction whom either conventional drainage by endoscopic retrograde cholangiopancreatography (ERCP) failed or as primary approach research setting. [1] [2] Although EUS-CDS has shown promising results, experience prior to pancreatoduodenectomy (PD) is still limited. [3] [4] [5] [6] Therefore, daily clinical practice multidisciplinary...
Collagenous sprue (CS) is a rare form of small bowel enteropathy characterised by thickened basement membrane and is, in most the literature, reported as part coeliac disease. Multiple treatment strategies are suggested CS, but there no standardised therapy. The aim this series to describe 4 cases CS propose thioguanine (6-TG) treatment.We reviewed CS. Data were obtained from our prospective database patients referred centre. Evaluation biopsies was performed an expert pathologist.None had...
Endoscopic ultrasound (EUS) with fine needle aspiration or biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and autoimmune pancreatitis analyze cyst fluid. The most common reported adverse event of and/or acute pancreatitis, which likely induced by same pathophysiological mechanisms as after endoscopic retrograde cholangiopancreatography (ERCP). According current European Society Gastrointestinal Endoscopy guideline, nonsteroidal anti-inflammatory drugs are...
Background and study aims Patients with symptomatic cholelithiasis can be stratified according to the 2019 European Society for Gastrointestinal Endoscopy (ESGE) guideline into low-, intermediate- high-likelihood groups presence of choledocholithiasis. For intermediate group, endoscopic ultrasound (EUS) or magnetic resonance cholangiopancreatography (MRCP) is recommended assess whether an retrograde (ERCP) necessary prior cholecystectomy. The aim was investigate adherence diagnostic...