A5053382355- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Liver physiology and pathology
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Complement system in diseases
- Iron Metabolism and Disorders
- Immunotherapy and Immune Responses
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lung Cancer Treatments and Mutations
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Acute Lymphoblastic Leukemia research
- Neuroendocrine Tumor Research Advances
- Diet, Metabolism, and Disease
- Chronic Myeloid Leukemia Treatments
- Cutaneous lymphoproliferative disorders research
- Lung Cancer Research Studies
- Sinusitis and nasal conditions
The University of Texas MD Anderson Cancer Center
2013-2024
Banner MD Anderson Cancer Center
2014-2024
Mayo Clinic in Arizona
2024
Hospital Regional Universitario de Málaga
2010-2024
University of Alicante
2024
Spanish National Cancer Research Centre
2021-2024
Mayo Clinic in Florida
2023
Universidad de La Frontera
2023
WinnMed
2023
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2018-2022
Liver cirrhosis is a very complex disease in which several pathological processes such as inflammation, fibrosis, and angiogenesis are closely integrated. We hypothesized that treatment with pharmacological agents multiple mechanisms of action will produce superior results to those achieved by only targeting individual mechanisms. This study thus evaluates the therapeutic use multitargeted receptor tyrosine kinase inhibitor Sunitinib (SU11248). The vitro effects SU11248 were evaluated human...
Unexpected donation after cardiac death (DCD) donors suffer arrest suddenly and are maintained with normothermic extracorporeal membrane oxygenation (NECMO) while consent for is obtained. The objective of this study was to determine whether ex vivo machine perfusion (NMP) improves upon the benefits NECMO in a large-animal model unexpected DCD liver transplant.Donor pigs underwent 90-minute were divided 3 groups. In first, livers preserved immediately cold storage (CS, n = 6). other 2 groups,...
Two cannabinoid (CB) receptor subtypes, CB1 and CB2, have been cloned characterized. Among other activities, activation by ligands may result in pro- or antifibrogenic effects depending on their interaction with respectively. In the current study, we investigated whether selective of hepatic CB2 modifies collagen abundance cirrhotic rats ascites. mRNA protein expression CB receptors liver control was assessed reverse transcription-polymerase chain reaction, Western blot,...
Understanding the pathogenesis of small-for-size (SFS) syndrome is critical to expanding applicability partial liver transplantation. We aimed characterize its acute presentation and association with alterations in hepatic hemodynamics, microstructure, regeneration a porcine model. Eighteen SFS transplants were performed. Donors underwent 70% hepatectomy. Partial grafts implanted into larger recipients. Whole also performed (n = 6). Recipients followed until death or for 5 days. Hemodynamics...
Abstract ZUMA-1 safety management cohort 6 investigated the impact of prophylactic corticosteroids and earlier and/or tocilizumab on incidence severity cytokine release syndrome (CRS) neurologic events (NEs) following axicabtagene ciloleucel (axi-cel) in patients with relapsed/refractory large B-cell lymphoma (R/R LBCL). Prior analyses limited follow-up demonstrated no Grade ≥3 CRS, a low rate NEs, high response rates, without negatively impacting axi-cel pharmacokinetics. Herein, long-term...
Background Livers from donation after circulatory determination-of-death (DCD) donors suffer ischemic injury during a preextraction period of cardiac arrest and are infrequently used for transplantation; they have the potential, however, to considerably expand donor pool. We aimed determine whether hypothermic oxygenated machine perfusion would improve or further deteriorate quality these livers using clinically relevant porcine model. Methods Donor were subjected 90 min preserved at 4°C...
The rapid evolution and uncontrolled use of Artificial Intelligence (AI) imposes significant challenges in education, which raises a reflection analysis its impact on the teaching-learning process within current educational system. For this reason, it is important to seek necessary strategies train students for emerging technological environment. Semiotic presented as potential tool innovate develop critical skills; because semiotics focuses signs codes that structure reality, provides...
In partial liver transplant, a reduction in the intrahepatic vascular bed produces rise portal vein flow and venous pressure gradient, leading to endothelial and, thereby, hepatocellular injury death process known as "small-for-size" (SFS) syndrome.To demonstrate that calibrated portocaval shunt prevents superfluous inflow porcine model of SFS transplant.Donor pigs (15-20 kg) underwent 70% hepatectomy. 2 groups, 6 mm (S6) (n = 6) or 12 (S12) Gore-Tex was placed between infrahepatic inferior...
The development of noninvasive biomarkers that reflect the state immunosuppression (IS) remains an unmet need in liver transplantation (LT). Torque Teno virus (TTV) is a highly prevalent, nonpathogenic DNA whose plasma levels may be associated with immune status host. aim this study was to assess role TTV as biomarker IS LT recipients. quantified by real‐time polymerase chain reaction at different time points during first year after transplant prospectively followed cohort 63 de novo...
Small-for-size (SFS) injury occurs in partial liver transplantation due to several factors, including excessive portal inflow and insufficient intragraft responses. We aim determine the role somatostatin plays reducing hyperperfusion preventing cascade of deleterious events produced small grafts. A porcine model 20% is performed. Perioperatively treated recipients receive untreated controls standard intravenous fluids. Recipients are followed for up 5 days. In vitro studies also performed...
The detection of methicillin–resistant Staphylococcus aureus (MRSA) and other emerging strains in meat-producing animals retail meat has increased the risk contamination food. aim this study was to determine prevalence characterize S. isolated from pork chain supply Chile. A total 487 samples were collected: 332 pigs at farms slaughterhouses (nasal, n = 155; skin, 177); 85 carcasses slaughterhouses; 70 supermarkets stores. isolation carried out by selective enrichment culture media....
We reviewed the spectrum of infections due to nontuberculous mycobacteria (NTM) in children with leukemia. Three acquired such infections. One patient developed pneumonia after cessation chemotherapy when Mycobacterium xenopi was identified his lung biopsy specimen. He required 2 years treatment antituberculous agents and clarithromycin. Cultures central peripheral blood specimens from two patients yielded fortuitum chelonae, respectively. Broviac catheters were likely source infection....
Ischemic‐type biliary lesions (ITBLs) arise most frequently after donation circulatory death (DCD) liver transplantation and result in high morbidity graft loss. Many DCD grafts are discarded out of fear for this complication. In theory, microvascular thrombi deposited during donor warm ischemia might be implicated ITBL pathogenesis. Herein, we aim to evaluate the effects administration either heparin or fibrinolytic drug tissue plasminogen activator (TPA) as means improve quality...
In this paper we describe the workflow followed to produce a 360-degree digital short film virtually recreate Roman Villa of L’albir (L’alfàs del Pi, Spain), from preliminary steps and production stages, use Extended Matrix tool document entire virtual reconstruction recreation process.
Abstract Adaptation of avian pathogenic E. coli (APEC) to changing host environments including virulence factors expression is vital for disease progression. FdeC an autotransporter adhesin that plays a role in uropathogenic Escherichia (UPEC) adhesion epithelial cells. Expression fdeC known be regulated by environmental conditions UPEC and Shiga toxin-producing (STEC). The observation previous study APEC strain IMT5155 which the gene was disrupted transposon insertion resulted elevated...
Akt is expected to be an effective target for the treatment of ischemia-reperfusion injury (I/R) due its anti-apoptotic properties and ability activate endothelial nitric oxide synthase (eNOS) enzyme. Therefore, this study was aimed determine efficacy active mutant (myr-Akt) decrease I/R in a model orthotopic liver transplantation pigs. In addition, we analyzed contribution Akt-mediated effects by using eNOS (S1179DeNOS) that mimics phosphorylation promoted sequence. Donors were treated with...
Lactic acidosis (LA) due to malignancy was first reported in patients with acute leukemia. Since then, several malignancies have been be associated LA. The pathophysiology of cancer-related LA is multifactorial and still poorly understood. In general, chemotherapy the only effective mean correcting malignancy-related by cytoreduction tumor cells while at same time decreasing malignant liver involvement leading improved clearance lactic acid. rare usually high mortality because advanced...
Patients who undergo hematopoietic stem cell transplant are at an increased risk of developing iron overload.To describe the effect hepatic overload on recipients and to validate utility histologic scoring system granules in liver.Records 154 post allogeneic patients were reviewed. Forty-nine underwent liver biopsy. Histologic was defined as a score 2 or greater (scale, 0-4).Twenty-eight 49 (57%) evaluated by biopsy had overload; 17 moderate severe (score, 3 4). In multivariate analysis,...