A5067502463- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Complement system in diseases
- Genetic and Kidney Cyst Diseases
- Hepatitis B Virus Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced MRI Techniques and Applications
- Breast Lesions and Carcinomas
- Heme Oxygenase-1 and Carbon Monoxide
- Methemoglobinemia and Tumor Lysis Syndrome
- Neurological Complications and Syndromes
- Viral Infections and Immunology Research
- Drug Transport and Resistance Mechanisms
- Caveolin-1 and cellular processes
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Pituitary Gland Disorders and Treatments
- Pancreatitis Pathology and Treatment
Hospital Universitario Son Espases
2021-2024
Hospital Clínic de Barcelona
2016-2022
Universitat de Barcelona
2015-2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2021
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017-2021
Centro de Investigación Biomédica en Red
2016
Sustained virological response (SVR) improves survival in post-liver transplant (LT) recurrent hepatitis C. However, the impact of SVR on fibrosis regression is not well defined. In addition, performance noninvasive methods to evaluate presence and portal hypertension (PH) post-SVR has been scarcely evaluated. We aimed investigate degree (decrease ≥1 METAVIR stage) after-SVR its associated factors C, as diagnostic capacity assessment liver PH after viral clearance. evaluated 112 C...
Abstract Background & Aims Clinical course and risk factors of death in non‐spontaneous bacterial peritonitis ( SBP ) infections are poorly known. We assessed the prevalence acute kidney injury AKI type‐1 hepatorenal syndrome HRS ), hospital, 30‐day 90‐day mortality 441 decompensated patients. Methods Analysis 615 non‐ (161 urinary UTI 95 cellulitis, 92 suspected infections, bacteraemias, 84 pneumonias, 21 bronchitis, 18 cholangitis, 15 spontaneous empyema, 13 secondary peritonitis, 24...
The development of noninvasive biomarkers that reflect the state immunosuppression (IS) remains an unmet need in liver transplantation (LT). Torque Teno virus (TTV) is a highly prevalent, nonpathogenic DNA whose plasma levels may be associated with immune status host. aim this study was to assess role TTV as biomarker IS LT recipients. quantified by real‐time polymerase chain reaction at different time points during first year after transplant prospectively followed cohort 63 de novo...
Abstract Background The optimal cardiovascular assessment of liver transplant (LT) candidates is unclear. We aimed to evaluate the performance CT‐based coronary tests (coronary artery calcium score [CACS] and CT angiography [CCTA]) a modification CAD‐LT (mCAD‐LT, excluding family history CAD) diagnose significant disease (CAD) before LT predict incidence post‐LT events (CVE). Methods retrospectively analysed single‐centre cohort who underwent non‐invasive tests; invasive (ICA) was performed...
Liver stiffness measurement (LSM) is a useful method to estimate liver fibrosis and portal hypertension. The inflammatory process that takes place in post–liver transplant acute cellular rejection (ACR) may also increase stiffness. We aimed explore the association between severity of ACR, as well assess relationship response treatment prospective study included 27 recipients with biopsy‐proven 30 stable normal tests, hepatitis C virus (HCV)–infected LT histologically diagnosed HCV...
Information on the risk factors, particularly kidney function, and impact of long-term cardiovascular events (CVE) after liver transplantation (LT) remains scarce.This is a retrospective, single-center study that included consecutive LT recipients between 2007 2017. The incidence CVE, their patient survival were investigated.We 627 recipients. CVE was 8% 20% at 12 60 months LT, respectively. independent factors (beyond mo) age (hazard ratio [HR], 1.04; 95% confidence interval [CI],...
Although liver transplantation (LT) recipients are at high cardiovascular risk (CVR), the management of CVR factors (CVRF) after LT is far from optimal and needs to be improved. For this reason, we developed a multidisciplinary protocol standardize identification, stratification, management, targets therapy CVRF during first post-LT year. The grade identification control 12 months in postintervention cohort (LT January 2018-January 2020, n = 150) were compared with who underwent between July...
Mannose-binding lectin (MBL) is synthesized by the liver and binds to microbes. MBL2 gene polymorphisms produce intermediate/low/null or normal MBL serum levels (MBL-deficient MBL-sufficient phenotypes, respectively). We aimed evaluate incidence severity of infection, rejection, survival within 1 year after transplantation (LT) according donor recipient polymorphisms. A repeated-event analysis for infection episodes (negative binomial regression, Andersen–Gill model) was performed in 240...
MicroRNAs (miRNAs) are small noncoding RNAs that can be detected in plasma and whose expression is associated with pathological processes. The role of miRNAs the noninvasive diagnosis T cell-mediated rejection (TCMR) after liver transplantation (LT) unclear. Thus, we aimed to assess effectiveness a panel 4 (155-5p, 122-5p, 181a-5p, 148-3p) diagnosing TCMR LT recipients graft dysfunction (GD), compared its accuracy previously published tests for based on routine laboratory parameters. From...
Abstract Liver transplantation ( LT ) is indicated in autoimmune hepatitis AIH for both acute presentation with liver failure and end‐stage chronic disease. Few studies have suggested an association between coagulation disorders a higher incidence of portal vein thrombosis PVT patients listed . The aim this study was to determine the thrombotic complications, particularly , cohort 37 undergoing because present before 30% (n=11) these compared 11% whole population transplanted our center P...
Hepatitis C virus (HCV) is a risk factor for porphyria cutanea tarda (PCT), rare disease originating in the liver characterised by overproduction of porphyrins. Although hepatitis infection highly prevalent among patients with porphyria, only minority develop PCT.To explore presence porphyrin abnormalities cohort asymptomatic C-infected and impact anti-viral therapy.Eighty-four consecutive HCV treated direct-acting antivirals after 1 January 2018 were longitudinally evaluated abnormalities....
Hepatitis C virus (HCV) treatment with direct-acting antivirals (DAA) can be associated reactivation of hepatitis B (HBV). We report a case kidney transplant recipient who had fatal severe HBV during for chronic DAA. Diagnosis was delayed due to undetectable surface antigen (HBsAg) by standard assays. The latter explained the presence HBsAg escape mutants. illustrates relevance HBV-DNA testing in recipients previous exposure HBV, even absence HBsAg, and particularly when liver test...
Despite rarely assessed, sexuality is a relevant domain in Quality of Life. We prospectively evaluated the impact direct-acting antiviral therapy on cohort 186 patients with chronic hepatitis C (HCV). Sexual dysfunction was assessed by validated scales CSFQ-14/CSFQ-VAS at baseline and one year after treatment finalization. Median age 55 years 87% had mild liver disease. Basal prevalence sexual (62%) fear HCV transmission (25%) were high. After cure, both CSFQ-VAS improved (P = .058 P < .01,...
This is a case report of patient with history liver transplant who developed interstitial pneumonitis due to immunosuppressive treatment. Everolimus-induced in recipients rare condition. observation aims highlight the significance being aware this condition, suspicious it, and getting proper diagnosis
Several mutations in the gene encoding apolipoprotein AI (apoAI) have been described as a cause of familial amyloidosis. Individuals with apoAI-derived (AApoAI) amyloidosis frequently manifest liver, kidney, laryngeal, skin and myocardial involvement. Although primary hypogonadism (PH) is considered almost pathognomonic this disease, until now, adrenal insufficiency (PAI) has not common clinical feature. Here, we report first kindred AApoAI which PAI well-documented. All family members...
Long-term cardiovascular (CV) events are a frequent cause of death and disability after liver transplant (LT). Although more in-depth, risk-adapted control CV risk factors may result in improved post-LT outcomes, an accurate stratification the LT recipients to better implement preventive strategies is lacking. Aortic pulse wave velocity (aPWV) surrogate arterial stiffness that has been suggested as biomarker risk; it never evaluated adult recipients.In single-center prospective study, we...