A5100690100- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- Cardiac Arrest and Resuscitation
- Erythrocyte Function and Pathophysiology
- Cancer-related molecular mechanisms research
- Neonatal and fetal brain pathology
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Protein Degradation and Inhibitors
Universitat de Barcelona
2015-2025
Hospital Clínic de Barcelona
2016-2025
Children's Hospital of Philadelphia
2019-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2014-2025
Hospital Arnau de Vilanova
2025
University of Chicago
2025
Complejo Hospitalario de Navarra
2024
University of Pennsylvania
2023
Universidad de Los Andes
2023
United in Health
2022
MYC alterations influence the survival of patients with diffuse large B-cell lymphoma. Most studies have focused on translocations but there is little information regarding impact numerical and protein expression. We analyzed genetic expression MYC, BCL2, BCL6, MALT1 in 219 cases rearrangement occurred as sole abnormality (MYC single-hit) 3% cases, concurrent BCL2 and/or BCL6 rearrangements double/triple-hit) 4%, amplifications 2% gains 19%. single-hit, double/triple-hit amplifications, not...
β-Catenin plays a dual role as key effector in the regulation of adherens junctions and transcriptional coactivator. Phosphorylation Tyr-654, residue placed last armadillo repeat β-catenin, decreases its binding to E-cadherin. We show here that phosphorylation Tyr-654 also stimulates association β-catenin basal transcription factor TATA-binding protein. The structural bases these different affinities were investigated. Our results indicate C-terminal tail interacts with domain, hindering...
The concept of "accelerated" chronic lymphocytic leukemia is frequently used by both pathologists and clinicians. However, neither histological criteria to define this form nor its clinical correlates prognostic impact have been formally defined in large series patients.Tissue biopsies from 100 patients with were analyzed for the size proliferation centers their rate as assessed mitosis count Ki-67 immunostaining. Histological patterns correlated main clinico-biological features outcome.A...
A retrospective study was performed to assess the outcome of patients with diffuse large B cell lymphoma (DLBCL) who did not achieve complete response or relapsed before and after use rituximab. Clinical features 816 (425 M/391 F; median age 63 years) diagnosed from 1991 2001 (pre-rituximab era, N = 348) 2002 2012 (rituximab 468) in a single institution were evaluated. Five hundred fifty-three achieved remission (CR), 57 partial (PR), 206 refractory overall survival 15, 1.5, 0.4 years,...
SARS-CoV-2 rapid antigen tests are an important public health tool.
Follicular lymphoma (FL) is one of the most common malignant lymphomas. The t(14;18)(q32;q21) translocation found in about 80% cases and plays an important role lymphomagenesis. However, molecular mechanisms involved development transformation this are not fully understood. Gain-of-function mutations NOTCH1 or NOTCH2 have recently been reported several B cell lymphoid neoplasms but these FL known. In study we investigated mutational status genes 112 FLs. were identified five two cases,...
Histologic transformation of low-grade B-cell lymphoma to diffuse large is associated with poor prognosis. Although plasma cell differentiation common in these lymphomas, an overt plasmablastic (PBL-T) has been only rarely reported. We report 6 cases PBL-T occurring 3 chronic lymphocytic leukemias (CLL) and follicular lymphomas. Five patients were men, the mean age was 65 years (range, 52 72 y). None them had history immunodeficiency. In occurred 34 85 months after initial diagnosis, it...
Hypoxia-induced upregulation of lincRNA-p21 in tumor tissue was previously shown by our group to be related poor prognosis resected non-small cell lung cancer (NSCLC) patients. In the present study, we have evaluated presence extracellular vesicles (EVs) from NSCLC patients and assessed its potential as a prognostic biomarker. High EV levels blood tumor-draining vein were associated with shorter time relapse overall survival. Moreover, multivariate analysis identified high an independent...
Aging | doi:10.18632/aging.204825. Fernanda Hernandez-Gonzalez, Neus Prats, Valentina Ramponi, José Alberto López-Domínguez, Kathleen Meyer, Mònica Aguilera, María Isabel Muñoz Martín, Daniel Martínez, Alvar Agusti, Rosa Faner, Jacobo Sellarés, Federico Pietrocola, Manuel Serrano
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is considered an indolent neoplasm and its pathogenesis not well known. We investigated the molecular characteristics of 19 SDRPL patients, 5 them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic studies identified complex karyotypes 2 cases, IGH rearrangements 3, PAX5 potentially TCL1 as partners each one them. Copy number arrays showed aberrations 69% tumors, including recurrent losses 10q23, 14q31-q32,...
Postmortem studies are crucial for providing insight into emergent diseases. However, a complete autopsy is frequently not feasible in highly transmissible diseases due to biohazard challenges. Minimally invasive (MIA) needle-based approach aimed at collecting samples of key organs without opening the body, which may be valid alternative these cases. We to: (a) provide biosafety guidelines conducting MIAs COVID-19 cases, (b) compare performance MIA versus autopsy, and (c) evaluate safety...
Clinical guidelines promote the identification of several targetable biomarkers to drive treatment decisions in advanced non-small cell lung cancer (NSCLC), but half all patients do not have a viable biopsy. Specimens from endobronchial-ultrasound transbronchial needle aspiration (EBUS-TBNA) are an alternative source material for initial diagnosis NSCLC, however their usefulness complete molecular characterization remains controversial. EBUS-TBNA samples were prospectively tested by...
We describe 36 patients with splenic marginal zone lymphoma (SMZL) transformation (SMZL-T), including 15 from a series of 84 SMZL diagnosed at the Hospital Clinic Barcelona (HCB) and 21 SMZL-T in other centres. In HCB cohort, cumulative incidence 5 years was 15%. Predictors for were cytopenias, hypoalbuminaemia, complex karyotype (CK) both Intergruppo Italiano Linfomi (ILL) simplified Haemoglobin, Platelet count, lactate dehydrogenase (LDH) extrahilar Lymphadenopathy (HPLL)/ABC scores (P <...
Abstract Background Streptococcus pneumoniae , a primary cause of community-acquired pneumonia (CAP), is typically treated with β-lactams and macrolides or quinolones. Corticosteroids are now recommended as adjunctive therapy in severe CAP to improve outcomes. I n this prospective randomized animal study, we evaluated the bactericidal efficacy various antibiotic regimens combined corticosteroids using porcine pneumococcal model. Results In 30 White-Landrace female pigs, was induced by...
Despite significant advancements in early detection and treatment, non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Specifically, early-stage cases, recurrence after surgery continues to be the principal death for these patients. The urgent need novel diagnostic prognostic biomarkers has directed attention towards PIWI-interacting RNAs (piRNAs), group small that regulate genomic stability epigenetics. Some piRNAs, including hsa_piR_022710,...