A5075612662- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Phagocytosis and Immune Regulation
- Electrospun Nanofibers in Biomedical Applications
- Neonatal Respiratory Health Research
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Cystic Fibrosis Research Advances
- Bone Tissue Engineering Materials
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Collagen: Extraction and Characterization
- Child Nutrition and Feeding Issues
- Axon Guidance and Neuronal Signaling
- Pediatric health and respiratory diseases
- Additive Manufacturing and 3D Printing Technologies
- Mesenchymal stem cell research
- Plant Pathogenic Bacteria Studies
- Cardiovascular Function and Risk Factors
- Caveolin-1 and cellular processes
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Gastroesophageal reflux and treatments
Universitat de Barcelona
2020-2025
Institute for Bioengineering of Catalonia
2023
Centro de Investigación Biomédica en Red
2023
Departament de Salut
2021
Three-dimensional printing is revolutionizing the development of scaffolds due to their rapid-prototyping characteristics. One most used techniques fused filament fabrication (FFF), which fast and compatible with a wide range polymers, such as PolyLactic Acid (PLA). Mechanical properties 3D printed polymeric are often weak for certain applications. A potential solution composite materials. In present work, metal-PLA composites have been tested material scaffolds. Three different materials...
Type I collagen hydrogels are of high interest in tissue engineering. With the evolution 3D bioprinting technologies, a number collagen-based scaffolds have been reported for development cell cultures. A recent proposal was to mix with silk fibroin derived from Bombyx mori silkworm. Nevertheless, due difficulties preparation and characteristics protein, several problems such as phase separation denaturation appear during procedure. Therefore, common solution is diminish concentration...
Mesenchymal stromal cell (MSC)-based therapy in acute respiratory diseases is based on MSC secretion of paracrine factors. Several strategies have proposed to improve this are being explored including pre-conditioning the MSCs prior administration. We here propose a strategy for improving therapeutic efficacy preconditioning by growing them native extracellular matrix (ECM) derived from lung. To end, bioink with tunable stiffness decellularized porcine lung ECM hydrogels was developed and...
Introduction: Aging induces functional and structural changes in the lung, characterized by a decline elasticity diminished pulmonary remodeling regenerative capacity. Emerging evidence suggests that most biomechanical alterations lung result from composition of extracellular matrix (ECM), potentially modulating behavior cells increasing susceptibility to chronic diseases. Therefore, it is crucial investigate mechanical properties aged lung. This study aims assess ECM due aging at both...
There is a growing interest in developing natural hydrogel-based scaffolds to culture cells three-dimensional (3D) millieu that better mimics the vivo cells' microenvironment. A promising approach use hydrogels from animal tissues, such as decellularized extracellular matrices; however, they usually exhibit suboptimal mechanical properties compared native tissue and their composition with hundreds of different protein complicates elucidate which stimulus triggers cell's responses. As simpler...
Cancer-associated fibroblasts (CAFs) are key regulators of the tumor microenvironment, promoting progression through extracellular matrix (ECM) remodeling and paracrine signaling, but signaling pathways controlling CAF function remain incompletely defined. Here, we demonstrate that RAS-PI3K plays a central role in activation ECM by collagen crosslinking, fibronectin organization, glycoprotein deposition at least partially YAP. Disruption interaction CAFs leads to structurally mechanically...
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that RAS-p110α signalling pathway, known its involvement various biological processes and tumorigenesis, regulates two vital aspects of response macrophages: initial monocyte movement later-stage lysosomal function. Disrupting this either a mouse model or through drug intervention, hampers leading to delayed resolution development more severe...
Abstract Background: Non-small cell lung cancer (NSCLC) is the most common subtype and leading cause of cancer-related deaths worldwide. Advances in treatment have focused on personalized approaches that use targeted therapies immunotherapies based protein, DNA, or RNA biomarkers. Assessing molecular biomarkers typically takes 1-2 weeks with challenges such as tissue exhaustion poor response prediction. Atomic Force Microscopy (AFM) allows for point-of care evaluation nanomechanical...
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that RAS–p110α signalling pathway, known its involvement various biological processes and tumourigenesis, regulates two vital aspects of response macrophages: initial monocyte movement later-stage lysosomal function. Disrupting this either a mouse model or through drug intervention, hampers leading to delayed resolution development more severe...
Metals such as titanium or Cr-Co alloys have been the most widely used materials in biomedical applications that require high mechanical properties, like implants. However, these present disadvantage of releasing ion metals into body. As an alternative, prostheses made ceramic developed, they produce less debris and better durability. The aim work is to test biocompatibility 3D-printed yttria-stabilized zirconia parts by culturing human bone-marrow-derived mesenchymal stem cells. Two...
Background Mechanical stretch of cancer cells can alter their invasiveness. During mechanical ventilation, lungs may be exposed to an increased amount stretch, but the consequences on lung tumours have not been explored. Methods To characterise influence ventilation behaviour tumours, invasiveness assays and transcriptomic analyses were performed in cell lines cultured static conditions or under cyclic stretch. Mice harbouring melanoma implants submitted metastatic spread was assessed....
Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages neocortical development, angiogenic factors chemokines such as CXCL12, ephrins, semaphorins assume crucial roles in orchestrating neuronal migration axon elongation postmitotic neurons. Here we explore the intrinsic properties developing marginal zone pallium migratory pathways distribution pioneer Cajal-Retzius cells. These neurons are generated several proliferative...
Since the emergence of 3D bioprinting technology, both synthetic and natural materials have been used to develop bioinks for producing cell-laden cardiac grafts. To this end, extracellular-matrix (ECM)-derived hydrogels can be scaffolds that closely mimic complex environments cell culture. This study presents a novel bioink based on exclusively derived from decellularized porcine myocardium loaded with human-bone-marrow-derived mesenchymal stromal cells. Hence, hydrogel patches without need...
The aim of this study was to compare the changes in solid's concentration before and after nebulization hypertonic saline (HS) vs. HS + hyaluronic acid (HA) isotonic (IS) bronchiectasis patients. <b>Methods:</b> This a post hoc analysis (NCT02392663), where 3 solutions (HS7%, HS7%+ HA0.1% IS0.9%) compared stable Sputum samples expectorated spontaneously were collected nebulization. To measure concentration, weighed liquid state, then frozen at -80⁰C lyophilized (Telstar Lyoquest-55 Plus,...
<title>Abstract</title> Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that RAS-p110α signalling pathway, known its involvement various biological processes and tumorigenesis, regulates two vital aspects of response macrophages: initial monocyte movement later-stage lysosomal function. Disrupting this either a mouse model or through drug intervention, hampers leading to delayed resolution...
Abstract Introduction: Complex structural remodelling of cells and extracellular matrix during cancer initiation progression elicit substantial biomechanical alterations, which can be measured by Atomic Force Microscopy (AFM) at the nanoscale level. Clinical translational evidence indicates that tissue nanomechanical signature (NS) a useful tool for rapid diagnosis, assessment aggressiveness. We demonstrated AFM-based Automated Reliable Tissue Diagnostics (ARTIDIS) platform represents valid...
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that RAS-p110α signalling pathway, known its involvement various biological processes and tumorigenesis, regulates two vital aspects of response macrophages: initial monocyte movement later-stage lysosomal function. Disrupting this either a mouse model or through drug intervention, hampers leading to delayed resolution development more severe...
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that RAS-p110α signalling pathway, known its involvement various biological processes and tumorigenesis, regulates two vital aspects of response macrophages: initial monocyte movement later-stage lysosomal function. Disrupting this either a mouse model or through drug intervention, hampers leading to delayed resolution development more severe...
<title>Abstract</title> Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that RAS-p110α signalling pathway, known its involvement various biological processes and tumorigenesis, regulates two vital aspects of response macrophages: initial monocyte movement later-stage lysosomal function. Disrupting this either a mouse model or through drug intervention, hampers leading to delayed resolution...