A5111631216- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic function and diabetes
- Vascular Procedures and Complications
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- 3D Printing in Biomedical Research
- Infectious Aortic and Vascular Conditions
- Liver Disease and Transplantation
- Acute Ischemic Stroke Management
- Pressure Ulcer Prevention and Management
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Cerebrovascular and Carotid Artery Diseases
- Clinical Nutrition and Gastroenterology
- Galectins and Cancer Biology
- Infective Endocarditis Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Health and Disease Prevention
- Bariatric Surgery and Outcomes
- Vector-borne infectious diseases
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center Utrecht
2018-2020
Dutch Institute for Clinical Auditing
2018-2020
Society for Vascular Surgery
2020
Haga Hospital
2020
University of Groningen
2020
Leiden University Medical Center
2020
Radboud Institute for Molecular Life Sciences
2020
Royal Brisbane and Women's Hospital
2016
The aims of the present study were to examine impact type 2 endoleaks (T2EL) on overall survival and determine need for secondary intervention after endovascular aneurysm repair (EVAR).A multicentre retrospective cohort in Netherlands was conducted among patients with an infrarenal abdominal aortic (AAA) who underwent EVAR between 2007 2012. primary endpoint (T2EL+) or without (T2EL-) a T2EL. Secondary endpoints sac growth, AAA rupture, intervention. Kaplan-Meier multivariable Cox regression...
Background: KEPs (kidney exchange programs) facilitate living donor kidney transplantations (LDKT) for patients with incompatible donors, who are typically higher risk than non-KEP because of sensitization and longer dialysis vintage. We conducted a comparative analysis graft outcomes factors both KEP transplants. Methods: All LDKTs performed in the Netherlands between 2004-2021 were included. The primary outcome measures one-, five- 10-year death censored survival (DCGS). secondary delayed...
ObjectiveInternational guidelines recommend supervised exercise therapy (SET) as primary treatment for all patients with intermittent claudication (IC), yet endovascular revascularisation (ER) might be more effective in iliac artery obstruction.MethodsThis was a multicentre RCT including IC caused by stenosis or occlusion (NCT01385774). Patients were allocated randomly to SET ER stratified maximum walking distance (MWD) and concomitant SFA disease. Primary endpoints MWD on treadmill (3.2...
Inguinal hernia belongs to the most common surgical pathology worldwide. Approximately, one third is asymptomatic. The value of watchful waiting (WW) in patients with asymptomatic or mildly symptomatic inguinal has been established a few randomised controlled trials (RCTs). aim this study was assess long-term outcomes RCT comparing WW and elective surgery.
The selection of a cell type for bioartificial liver (BAL) systems the treatment patients with acute failure is in part determined by issues concerning patient safety and availability. Consequently, mature porcine hepatocytes (MPHs) have been widely applied BAL systems. success clinical application is, however, largely dependent on functionality stability hepatocytes. Therefore, we compared herein general metabolic functional activities MPHs human (MHHs) Academic Medical Center (AMC)-BAL...
The development of a symptomatic lymphocele (SL) is frequent postoperative surgical complication after kidney transplantation. It may lead to pain and discomfort cause transplant malfunction or even secondary graft loss. A large cohort renal recipients was investigated identify the possible risk factors for SL.All patients single centre were retrospectively analysed SL between January 2010 December 2017. group compared control from same cohort.45 out 1003 transplanted developed an (incidence...
A numerical model to investigate fluid flow and oxygen (O(2)) transport consumption in the AMC-Bioartificial Liver (AMC-BAL) was developed applied two representative micro models of AMC-BAL with different gas capillary patterns, each combined proposed hepatocyte distributions. Parameter studies were performed on configuration gain insight flow, shear stress distribution availability AMC-BAL. We assessed function internal oxygenator, effect changes parameters time change from an experimental...
ObjectiveAcute type B aortic dissection (ATBD) is a rare yet serious cardiovascular event that potentially has an impact on health related quality of life (HRQoL). However, long term follow up data this topic are scarce. This study aimed to review the HRQoL among patients treated for ATBD.MethodsIn multicentre, cross sectional survey study, consecutive with ATBD between 2007 and 2017 in four referral centres Netherlands were retrospectively included baseline collected. Between 2019 2021 36...
The variety of methods for measuring bioactive mass and functionality bioartificial livers (BAL) is confusing prevents accurate comparison reported data. Here we present a different hepatocyte quantification propose that estimation cell pellet volume after centrifugation generates reliable, useful fast method. In addition correlation made between several function tests performed in 26 bioreactors to assess their predictive value. ammonia eliminating capacity was found be most other liver...
Abstract: Long‐term culturing of primary porcine hepatocytes (PPH) inside the Academic Medical Center (AMC)‐bioartificial liver is characterized by increased anaerobic glycolysis. Recommendations to increase oxygen availability were proposed in a previous numerical study and experimentally evaluated this study. Original bioreactors as well new configuration with 2.2‐fold thinner nonwoven matrix 2‐fold more capillaries loaded PPHs oxygenated different gas pressures resulting medium pO 2 (pO...
Profound neuromuscular blockade (NMB) during anaesthesia has been shown to reduce postoperative pain scores, when compared with a moderate block. We hypothesised that profound NMB laparoscopic donor nephrectomy (LDN) could also improve the early quality of recovery after surgery.To compare effectiveness versus LDN in enhancing recovery.A phase IV, double-blinded, randomised controlled trial.Multicentre trial, from November 2016 December 2017.A total 101 living kidney donors scheduled for...
Previous studies have used supplements to increase dietary nitrate intake in clinical populations. Little is known about whether effects can also be induced through vegetable consumption. Therefore, the aim of this study was assess impact nitrate, nitrate-rich vegetables (NRV) and beetroot juice (BRJ) supplementation, on plasma nitrite concentrations, exercise tolerance, muscle oxygenation, cardiovascular function patients with peripheral arterial disease. In a randomized crossover design,...
Clinically applied bioartificial liver (BAL) support systems are difficult to compare with regard overall hepatocyte-specific function and clinical outcome. We compared two clinically BAL systems, the Modular Extracorporeal Liver Support (MELS) CellModule AMC-bioartificial (AMC-BAL) in an vitro set-up. Both were loaded 10 billion freshly isolated porcine hepatocytes, cultured for 7 days tested on 1, 2, 4 7. Average decrease functions over was 9.7%. Three parameters differed between both...
A comprehensive understanding of the mechanisms that underlie hepatic differentiation inside a bioartificial liver (BAL) device is obtained when functional, histological, and gene expression analyses can be combined. We therefore developed novel cell-sampling technique enabled us to analyze adherent hepatocytes BAL during 5-day culture period, without necessity terminating culture. Biochemical data showed hepatocyte-specific functions were relatively stable, despite an increase in glycolytic...
<i>Background:</i> Mechanisms underlying hepatic zonation are not completely elucidated. In vitro test systems may provide new insights into current hypotheses. this study, zonally expressed proteins, i.e. glutamine synthetase (GS; pericentral) and carbamoylphosphate (CPS; periportal), were tested for their expression patterns in the bioartificial liver of Academic Medical Center (AMC-BAL). <i>Methods:</i> Distribution organization porcine hepatocytes inside AMC-BAL...
Acute type B aortic dissection is a cardiovascular emergency with considerable mortality and morbidity risk. Male-female differences have been observed in disease; however, literature on scarce.
Bioartificial liver (BAL) systems have been developed to bridge patients with acute failure (ALF) transplantation or regeneration. Clinical application of BAL is dependent on the supportive quality cells used and direct availability whole system. Reliable transport from laboratory remote treatment centers therefore inevitable. Subsequently, preservation conditions play a crucial role during BAL, temperature being one most determining factors. In this study, we assessed effect subnormothermic...