Florent Delbos
A5077457122- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Blood transfusion and management
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Renal and Vascular Pathologies
- COVID-19 Impact on Reproduction
- Blood disorders and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Neurological Complications and Syndromes
- Adenosine and Purinergic Signaling
- Pregnancy and Medication Impact
- Acute Myeloid Leukemia Research
Établissement Français du Sang
2015-2025
Centre Pays de la Loire
2018-2025
Inserm
2015-2022
Nantes Université
2022
Université de Strasbourg
2022
Institut de Transplantation Urologie en Nephrologie
2022
Université Paris Cité
2012-2016
Institut Necker Enfants Malades
2016
Assistance Publique – Hôpitaux de Paris
2014
Hôpital Bichat-Claude-Bernard
2012
Significance Statement Identifying biomarkers for predicting kidney transplant failure requires better understanding of the immune response to chronic allogeneic stimulation. The authors demonstrated that 1 year after transplantation, composition CD8 + memory T cell subsets in blood—specifically ratio terminally differentiated effector (TEMRA) and cells—is associated with risk subsequent graft adds predictive value a previously reported eight-variable clinical score. They also found TEMRA...
Abstract The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. major complex (MHC) class I MICA gene is a candidate locus. Here, we investigate its role in French multicenter cohort 1,356 kidney transplants. mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45–3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) strongly increased...
BACKGROUND In Caucasians, fetal/neonatal alloimmune thrombocytopenia (FNAIT) is most frequently caused by maternal alloimmunization against the human platelet antigen HPA‐1a. The serious complication of severe FNAIT intracranial hemorrhage (ICH). ICH mainly occurs in utero; therefore, there a need to identify noninvasive predictive factors facilitate early identification this condition and determine response therapy. STUDY DESIGN AND METHODS We studied gynecologic immunogenetic variables...
Decreased immunosuppression has been proposed for kidney transplant recipients infected with coronavirus disease 2019 (COVID-19), but the impact on alloreactive immune response during and after infection poorly investigated. We evaluated occurrence of antihuman leukocyte antigen (HLA) donor-specific antibodies (DSAs) (post-COVID-19) rejection episodes COVID-19 particular focus modulation.Kidney from 2 French institutions had anti-HLA antibody screening before COVID-19. Management...
The human immune system contains cells with either effector/memory or regulatory functions. Besides the well-established CD4+CD25hiCD127lo T (Tregs), we and others have shown that B can also functions since their frequency number are increased in kidney graft tolerance cell depletion as induction therapy may lead to acute rejection. On other hand, CD28-CD8+ represent a subpopulation potent In current study, tested hypothesis allograft rejection be linked an imbalance of cells. Based on large...
Donor-specific anti-HLA antibodies (DSAs) are a major risk factor associated with renal allograft outcomes. As trigger of B cell antibody production, T follicular helper cells (Tfhs) promote DSA appearance. Herein, we evaluated whether circulating Tfhs (cTfhs) the genesis antibody-mediated rejection. We measured cTfh levels on day transplantation and one year after in blood from prospective cohort 237 patients without during first post-transplantation. Total cTfhs were characterized as...
The sensitization to HLA antigens is caused mainly by pregnancy and transfusions; however, anti-HLA antibodies also may be detected in nulliparous females nontransfused males, thus specifically hematopoietic stem cell transplantation (HSCT) donors. In such cases, the impact on HSCT outcome known only for platelet transfusion refractoriness. This study addresses graft-versus-host disease (GVHD) of voluntary unrelated Among 100 donor/recipient (D/R) pairs, 33 82 showed at least 1 class I II...
Three weeks after single-lung transplantation for pulmonary fibrosis, a patient with high serum levels of de novo donor-specific antibodies received high-dose intravenous immunoglobulin (IVIG) infusion (scheduled dose: 2 g/kg on days) to prevent antibody-mediated rejection. Within the first hours completion infusions, he experienced acute lung injury involving transplanted lung. Given clinical evolution and absence an alternative diagnosis, transfusion-related (TRALI) was diagnosed. The IVIG...
Informing kidney transplant recipients of their prognosis and disease progression is primary importance in a patient-centred vision care. By participating decisions from the outset, may be more adherent to complex medical regimens due enhanced understanding.We proposed include repeated measurements serum creatinine (SCr), addition baseline characteristics, order obtain dynamic predictions graft failure risk that could updated continuously during patient follow-up. Adult French Données...
The estimated glomerular filtration rate (eGFR) measured at 1 year is the usual benchmark applied in kidney transplantation (KT). However, acting on earlier eGFR values could help managing KT during first post-operative year. We aimed to assess prognostic value for long-term graft survival of early (3 months) quantification and proteinuria following KT.The 3-, 6- 12-month using Modified Diet Renal Disease equation (eGFRMDRD) was determined 754 patients who underwent their between 2000 2010...
Tacrolimus, the cornerstone immunosuppression after simultaneous pancreas and -kidney (SPK) transplantation, may exert nephrotoxic diabetogenic effects. We therefore prospectively compared in an open-label, randomized, monocentric, 5-year follow-up study, a tacrolimus- sirolimus-based immunosuppressive regimen. Randomization using block method allowing blind allocation was done at time of surgery. All patients received anti-thymocyte globulin maintenance therapy with tacrolimus,...
Abstract Matching for HLA‐A, ‐B, ‐C, and ‐DRB1 loci (8/8 match) is currently the gold standard unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at HLA‐DQB1 (10/10 match). However, there increasing evidence that matching HLA‐DRB3/4/5 may help to lower transplant‐related morbidity mortality. We therefore investigated impact of mismatches on outcomes in 1975 who received a first 10/10 (MUD) HCT France from 2000 2012 hematological malignancy....
Most studies comparing the efficacy of hypothermic machine perfusion (HMP) versus static cold storage (SCS) are based on short-term outcomes. We aimed to better evaluate mid-term impact HMP in patients receiving expanded criteria donor (ECD) kidneys.The analyses were French Données Informatisées et VAlidées en Transplantation (DIVAT) observational cohort. Patients aged ≥45 years transplanted for first or second times from an ECD since 2010 studied. Our study reported graft and/or patient...