A5113243372- Stress Responses and Cortisol
- Ginseng Biological Effects and Applications
- Plant-derived Lignans Synthesis and Bioactivity
- Tryptophan and brain disorders
- Gut microbiota and health
- Natural Compound Pharmacology Studies
First Affiliated Hospital of Henan University of Science and Technology
2024-2025
The microbiota-gut-brain axis plays a pivotal role in neuropsychiatric disorders, particularly depression. Escitalopram (ESC) is first-line antidepressant, however, its regulatory mechanisms on the treatment of depression remain unclear. antidepressant effects ESC were evaluated using forced swim test Wistar-Kyoto (WKY) rats, while damage gut and brain regions was assessed through H&E staining immunohistochemistry. therapeutic WKY rats with depression-like behavior investigated 16S rRNA...
Podophyllotoxin (PPT) is a lignan derived from the roots and stems of Podophyllum plant. However, its enterotoxicity restricts clinical application. The underlying mechanisms by which PPT exerts action remain largely elusive. This study aimed to evaluate molecular PPT-induced utilizing concept toxicological evidence chain. Changes in body weight, behavior, histopathological biochemical markers rats were observed. Additionally, microbiome, metabolome, transcriptome analyses integrated...