A5100765482- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Mesenchymal stem cell research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Diabetes Treatment and Management
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Heart Rate Variability and Autonomic Control
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
China Pharmaceutical University
2025
The University of Texas Southwestern Medical Center
2024
Second Xiangya Hospital of Central South University
2014-2024
Central South University
2014-2024
Zhejiang University
2023
University of South China
2019
Qingdao University of Science and Technology
2017
Xiangya Hospital Central South University
2004-2014
Third People's Hospital of Huzhou
2009
Abstract Background Previous studies reported the prognostic value of atherogenic index plasma (AIP) in course atherosclerosis and other cardiovascular diseases (CVDs). Still, predictive utility AIP is unknown among patients with type 2 diabetes mellitus (T2DM). Methods This was a secondary analysis Action to Control Cardiovascular Risk Diabetes (ACCORD) study, which randomized 10,251 long-lasting T2DM. ROC curve used determine an optimal threshold for AIP, study population divided into high...
This study was designed to examine whether transplantation of mesenchymal stem cells (MSCs) overexpressing miR-126 enhances angiogenesis in the infarcted myocardium mice.MSCs were harvested from mice using density gradient centrifugation and adherent culture. MSCs transfected with lentiviral vectors carrying mature miR-126. Mice models myocardial infarction established by ligation coronary artery. The ligated animals randomly divided into three groups (15 each) after two weeks,...
Vascular smooth muscle cell (VSMC) senescence in the vasculature results vascular aging as well age-related diseases, while metformin improves inflamm-aging profile by enhancing autophagy. However, metformin's impact on VSMC is largely undefined. To test hypothesis that exerts an anti-senescence role restoring autophagic activity VSMCs and tissues. Animal models established angiotensin II (Ang II) induction physiological senescent primary from aortas of elderly patients were treated with...
<b><i>Background:</i></b> The aim of this research was to study whether transplantation mesenchymal stem cells (MSCs) overexpressing microRNA-1 into mouse infarcted myocardium can enhance cardiac myocyte differentiation and improve function efficiently. <b><i>Methods:</i></b> Eight-week-old female C57BL/6 mice underwent ligation the left coronary artery produce models myocardial infarction. ligated animals were randomly divided 4 groups (20 in...
The modification of cardiac energy metabolism during atrial fibrillation (AF) has been demonstrated in previous studies, indicating a close association between these 2 processes. aim the present study was to identify underlying mechanisms via profiling expression metabolism-related proteins left appendage (LAA) patients with AF. Isobaric tag for relative and absolute quantification-coupled 2-D liquid chromatography-tandem mass spectrometry (iTRAQ-coupled LC-MS/MS) used profile LAA from...
Abstract The endothelial cell (EC)-specific miRNA, miR-126, is known to promote angiogenesis in response angiogenic factors by repressing negative regulators of signal transduction pathways; however, whether miR-126 might regulate the differentiation stem cells toward lineage remains unknown. To answer this question, study mesenchymal (MSCs) harvested from C57BL/6 mouse bone marrow were transfected with (MSC ) using recombinant lentiviral vectors. Results showed para-secretion and expression...
Background: P-wave indices are appealing markers for predicting atrial fibrillation (AF) recurrences post ablation.Objective: This study evaluates the value of P wave to predict pulmonary vein isolation (PVI) in patients with paroxysmal AF.Methods: We selected 198 (57 ± 8 years, 150 males) symptomatic drug-refractory AF undergoing PVI our hospital.A 12-lead electrocardiogram was used measure duration lead II, terminal force (PWTF) V1, axis and dispersion.Results: During a follow-up 9 3...
Previous studies have found that predicted fat mass and lean body may act differently on adverse events. However, the cardiovascular prognostic value of in patients with type 2 diabetes mellitus (T2DM) has not yet been investigated. We sought to investigate relation between or risk disease T2DM.We conducted a post hoc analysis data from Action Control Cardiovascular Risk Diabetes (ACCORD) study major events T2DM. used sex-specific quartiles index (BMI; kg/m2) (kg/m2). defined event as...
Abstract Background Heart failure (HF) is one of the most serious health concerns worldwide. Anemia a highly prevalent comorbidity and outcome predictor in HF patients. Sodium glucose co-transport 2 (SGLT2) inhibitors have been demonstrated to reduce risk cardiovascular death hospitalization Purpose This investigator-initiated, interventional, prospective, double-blind, multicenter study designed investigate whether anemia correction prerequisites determinants related beneficial effects...
Abstract Background The American Heart Association recently released an updated algorithm for evaluating cardiovascular health—Life’s Essential 8 (LE8). However, the associations between changes in LE8 score over time and risk of disease (CVD) remain unclear. Methods We investigated 6-year (2006–12) subsequent CVD events (2012–20) among 53 363 Chinese men women from Kailuan Study, who were free 2012. was calculated based on eight components: diet quality, physical activity, smoking status,...
PCSK9 (proprotein convertase subtilisin/kexin type 9) plays a critical role in cholesterol metabolism via the PCSK9-LDLR (low-density lipoprotein receptor) axis liver; however, evidence indicates that directly contributes to pathogenesis of various diseases through mechanisms independent its LDL-cholesterol regulation. The objective this study was determine how acts on vascular smooth muscle cells (SMCs), contributing degenerative disease. Approach and Results: We first examined effects...
BACKGROUND: T cells are central to the immune responses contributing hypertension. LGMN (legumain) is highly expressed in cells; however, its role pathogenesis of hypertension remains unclear. METHODS: Peripheral blood samples were collected from patients with hypertension, and cluster differentiation (CD)4+ sorted for gene expression Western blotting analysis. TLGMNKO (T cell–specific LGMN-knockout) mice (Lgmn f/f /CD4 Cre ), regulatory cell (Treg)–specific LGMN-knockout /Foxp3 YFP RR-11a...
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many medical conditions, including hypertension, diabetes, obesity, sleep apnea, and heart failure, increase risk for AF. Cardiomyocytes have unique metabolic characteristics to maintain adenosine triphosphate production. Significant changes occur in myocardial metabolism Glucagon-like peptide-1 receptor agonists (GLP-1RAs) been used control blood glucose fluctuations weight treatment of type 2 diabetes obesity. GLP-1RAs also...
Background: The effect of flavonoid consumption on all-cause and special-cause mortality remains unclear among populations with hypertension. Methods: A total 6110 people hypertension from three NHANES survey cycles (2007–2008, 2009–2010, 2017–2018) were enrolled in this study. Cox proportional hazard models conducted to estimate the association between intake flavonoids subclasses all-cause, cancer-related, cardiovascular disease (CVD)-related mortality. Nonlinear relationships identified...