A5071023660- RNA modifications and cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Marine Bivalve and Aquaculture Studies
- Aquaculture disease management and microbiota
- Congenital heart defects research
- Aquatic Invertebrate Ecology and Behavior
- Invertebrate Immune Response Mechanisms
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Physiological and biochemical adaptations
- Marine Biology and Environmental Chemistry
- Aquaculture Nutrition and Growth
- Calcium Carbonate Crystallization and Inhibition
- Ferroptosis and cancer prognosis
- Flavonoids in Medical Research
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
Anhui Provincial Hospital
2025
University of Science and Technology of China
2019-2025
Shanghai Ocean University
2009-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Xiamen University
2021-2024
North China University of Science and Technology
2023-2024
Hunan Provincial Maternal and Child Health Hospital
2024
Yuhuangding Hospital
2020-2024
Qingdao University
2020-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Poor understanding of the basic biology Mycobacterium tuberculosis (MTB), etiological agent tuberculosis, hampers development much-needed drugs, vaccines, and diagnostic tests. Better experimental tools are needed to expedite investigations this pathogen at systems level. Here, we present a functional MTB proteome microarray covering most an ORFome library. We demonstrate broad applicability by investigating global protein-protein interactions, small-molecule-protein binding, serum biomarker...
Emerging evidence suggested that epigenetic regulators can exhibit both activator and repressor activities in gene transcriptional regulation disease development, such as cancer. However, how these dual are regulated coordinated specific cellular contexts remains elusive. Here, it is reported KDM5C, a repressive histone demethylase, unexpectedly activates estrogen receptor alpha (ER
Abstract This study aims at suggesting an end-to-end algorithm based on a U-net-optimized generative adversarial network to predict anterior neck lower jaw angles (ANLJA), which are employed define fetal head posture (FHP) during nuchal translucency (NT) measurement. We prospectively collected 720 FHP images (half hyperextension and half normal posture) regarded manual measurement as the gold standard. Seventy percent of were used fit models, rest evaluate them in group, group (NPG), total...
Chemoprevention has been a pivotal and effective strategy during the skin cancer treatment. Using human normal tumor samples, we demonstrated that both expression activity levels of pyruvate kinase M2 (PKM2) were higher in tissues than tissues, suggesting PKM2, one important metabolic enzyme, might serve as target for prevention and/or therapy. Shikonin, small-molecule active chemical, studied an anti-cancer drug candidate models. However, mechanism action chemopreventive potential shikonin...
PRMT1 plays a vital role in breast tumorigenesis; however, the underlying molecular mechanisms remain incompletely understood. Herein, we show that critical RNA alternative splicing, with preference for exon inclusion. methylome profiling identifies methylates splicing factor SRSF1, which is SRSF1 phosphorylation, binding RNA, and In tumors, overexpression associated increased arginine methylation aberrant inclusion, are cancer cell growth. addition, identify selective inhibitor, iPRMT1,...
Abstract Background The American Heart Association recently released an updated algorithm for evaluating cardiovascular health—Life’s Essential 8 (LE8). However, the associations between changes in LE8 score over time and risk of disease (CVD) remain unclear. Methods We investigated 6-year (2006–12) subsequent CVD events (2012–20) among 53 363 Chinese men women from Kailuan Study, who were free 2012. was calculated based on eight components: diet quality, physical activity, smoking status,...
CARM1, belonging to the protein arginine methyltransferase (PRMT) family, is intricately associated with progression of cancer and viewed as a promising target for both diagnosis therapy. However, number specific potent CARM1 inhibitors limited. We herein discovered inhibitor, iCARM1, that showed better specificity activity toward compared known inhibitors, EZM2302 TP-064. Similar knockdown, iCARM1 suppressed expression oncogenic estrogen/ERα-target genes, whereas activated type I interferon...
Abstract The association between normal thyroid function and diabetic kidney disease (DKD) has gained increasing attention. present study evaluated the relationship hormone levels DKD in type 2 diabetes mellitus (T2DM) patients. A total of 862 patients were enrolled this cross-sectional Xi ’ an, Shaanxi Province, China. subjects for anthropometric measurements, DKD. Of patients, 246 (28.5%) suffered from DKD, prevalence did not differ men women. showed a significantly decreasing trend across...
Lung cancer is the most common type of malignant tumor in world.1Siegel R.L. Miller K.D. Jemal A. Cancer statistics, 2018.CA J Clin. 2018; 68: 7-30Crossref PubMed Scopus (6441) Google Scholar MNNG HOS Transforming gene (MET) exon 14 mutations occur approximately 4% lung cancers.2Baldacci S. Kherrouche Z. Descarpentries C. et al.MET splicing sites mutations: a new therapeutic opportunity cancer.Rev Mal Respir. 35: 796-812Google The efficacy crizotinib with MET skipping mutation has been...
Grass Carp Reovirus (GCRV) and Aeromonas hydrophila (Ah) are the causative agents of haemorrhagic disease in grass carp. This study aimed to investigate molecular mechanisms immune responses at miRNA, mRNA, protein levels carp kidney cells (CIK) infected by (GCRV, NV) hydrophilus (Bacteria, NB) gain insight into their pathogenesis. Within 48 h infection with (GCRV), 99 differentially expressed microRNA (DEMs), 2132 genes (DEGs), 627 proteins (DEPs) were identified sequencing; a total 92...
To develop a nomogram for predicting the risk of progression from prediabetes to diabetes and provide quantitative predictive tool early clinical screening high-risk populations diabetes.This study was retrospective cohort part investigation conducted Risk Evaluation cAncers in Chinese diabeTic Individuals: lONgitudinal (REACTION) study. A total 1857 prediabetic participants at baseline underwent oral glucose tolerance test hemoglobin A1c (HbA1c) testing after 3 years. The areas under...
Malignant cells exhibit reduced period circadian regulator 3 (PER3) expression. However, the underlying mechanisms of variations in PER3 expression cancers and specific function tumor progression remain poorly understood.
Human immunodeficiency virus type 1 (HIV-1) integrase mediates the integration of reverse-transcribed viral cDNA into genome host for stable maintenance and persistence HIV-1 infection. In this study, relationships between (HIV-1 IN) three SUMO conjugation pathway proteins, as well effects these associations, were investigated. The overexpression SUMO1/SUMO2 Ubc9 changed intracellular localization IN from a diffuse distribution to punctate localization. SUMO1, SUMO2 shown interact with IN....
Arrhythmogenic cardiomyopathy (ACM) is an inherited that rarely diagnosed in infants or young children. However, some significant homozygous compound heterozygous variants contribute to more severe clinical manifestations. In addition, inflammation of the myocardium and ventricular arrhythmia might lead misdiagnosis with myocarditis. Here, we describe 8-year-old patient who had been misdiagnosed Timely genetic sequencing helped identify this case as ACM induced by a variant DSG2. The proband...