A5101524989- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Oral microbiology and periodontitis research
- SARS-CoV-2 and COVID-19 Research
- Biochemical and Molecular Research
- RNA modifications and cancer
- vaccines and immunoinformatics approaches
- RNA and protein synthesis mechanisms
- SARS-CoV-2 detection and testing
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Healthcare Systems and Reforms
- Endodontics and Root Canal Treatments
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Gut microbiota and health
- Microbial Natural Products and Biosynthesis
- Bacterial Genetics and Biotechnology
- Advanced Drug Delivery Systems
Eye & ENT Hospital of Fudan University
2025
Zhejiang Center for Disease Control and Prevention
2016-2024
Center for Tuberculosis Control of Guangdong Province
2014-2024
Guangdong Pharmaceutical University
2024
Chinese Center For Disease Control and Prevention
2010-2023
Shanghai Jiao Tong University
2018-2023
Guangzhou Medical University
2012-2022
Guangdong Medical College
2022
Shenzhen Center for Disease Control and Prevention
2022
Northwest A&F University
2022
Mycobacterium tuberculosis is a hard-to-eradicate intracellular pathogen that infects one-third of the global population. It can live within macrophages owning to its ability arrest phagolysosome biogenesis. Autophagy has recently been identified as an effective way control mycobacteria by enhancing phagosome maturation. In present study, we demonstrate novel role miR-155 in regulating autophagy-mediated anti-mycobacterial response. Both vivo and vitro studies showed expression was...
The gut-lung axis has been implicated as a potential therapeutic target in lung disorders. While increasing evidence suggests that gut microbiota plays critical role regulating host immunity and contributing to tuberculosis (TB) development progression, the underlying mechanisms whereby may impact TB outcomes are not fully understood. Here, we found broad-spectrum antibiotics treatment increased susceptibility Mycobacterium (M. tuberculosis) infection modulated pulmonary inflammatory...
Poor understanding of the basic biology Mycobacterium tuberculosis (MTB), etiological agent tuberculosis, hampers development much-needed drugs, vaccines, and diagnostic tests. Better experimental tools are needed to expedite investigations this pathogen at systems level. Here, we present a functional MTB proteome microarray covering most an ORFome library. We demonstrate broad applicability by investigating global protein-protein interactions, small-molecule-protein binding, serum biomarker...
BACKGROUND:Adverse events are under-appreciated negative consequences that significant clinical problems for patients undergoing anti-MDR-TB treatment due to longer duration of and more need concurrent use multiple second-line drugs. The aim this study was determine the incidence adverse their impact on MDR-TB therapy outcome, identify possible drug-event pairs in China. MATERIAL AND METHODS:An ambispective cohort conducted based hospital medical records, which included a retrospective...
Abstract Objective Multidrug‐resistant tuberculosis ( MDR ‐ TB ) has been a major threat for successful control. We examined the relationship between social support and treatment outcomes in patients evaluated barriers to support. Methods Retrospective cohort study with enrolled Global Fund programme 1 January 2009 30 June 2014 Zhejiang, China. reviewed all patients’ diagnoses outcomes. In‐depth interviews were conducted 10 community health workers patients. Pathway analysis was employed...
Background: Around the globe, moderate cases account for largest proportion of all coronavirus disease 2019 (COVID-19) patients, and deteriorated patients contribute most in mortality. However, published articles failed to address deterioration details cases, especially on when how they deteriorated. Methods: All COVID-19 hospitalized Guangdong Province from January 14 March 16, 2020, were included this multicenter retrospective cohort study divided into non-deteriorated groups according...
<sec> <title>BACKGROUND</title> Catastrophic health expenditures (CHE) severely impact families, especially in the context of respiratory diseases and tuberculosis. This study evaluates determinants CHE construct nomogram prediction, with a focus on diverse impacts regional disparities income levels Guangdong Province, China, drawing from National Health Services Surveys (NHSS) conducted 2013 2023. </sec> <title>OBJECTIVE</title> To evaluate catastrophic among individuals tuberculosis using...
The current study aimed to evaluate the application value of domestic otolaryngology-specific flexible-arm robotic system in resection throat tumors. A 53-year-old male patient diagnosed with a left-sided tumor underwent assistance at ENT Institute and Department Otorhinolaryngology, Eye & Hospital, Fudan University October 2024. Intraoperative parameters including positioning time, operation intraoperative blood loss, vital signs, length hospital stay were observed. postoperative...
Objective The aim of this study was to examine the effect ursolic acid ( UA ) and oleanolic OA ), triterpenoid compounds that are isolated from many edible medicinal plants, on cariogenic microorganisms biofilms. Methods A microtitre plate dilution assay used determine minimum inhibitory concentration MIC bactericidal MBC against two ctinomyces spp. four S treptococcus antibacterial activity assessed by crystal violet staining, scanning electron microscopy SEM confocal laser CLSM ). Results...
ABSTRACT Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated protein (Cas) systems are prokaryotic adaptive immune against invading nucleic acids. CRISPR locus variability has been exploited in evolutionary and epidemiological studies of Mycobacterium tuberculosis , the causative agent tuberculosis, for over 20 yr, yet biological function this type III‐A system is largely unexplored. Here, using cell biology biochemical, mutagenic, RNA‐seq approaches, we show...
Pesticide research and development has entered an era of safety, efficiency, environmental friendliness. Discovery effective active products directly or indirectly from plant secondary metabolites as pesticide candidates been one the current focuses. Herein, two series new ester amide derivatives were prepared by structural modifications a natural coumarin-type product osthole at its C-4′ position. Their structures characterized IR, mp, 1H NMR, HRMS. Confirmation steric configuration seven...
Abstract Background More than 1 million tuberculosis (TB) patients are receiving the standard anti-TB treatment provided by China National Tuberculosis Prevention and Control Scheme (CNTS) in every year. Adverse reactions (ADRs) induced drugs could both do harm to lead failure. The ADACS aimed explore ADRs' incidences, prognoses, economical public health impacts for TB control, build a DNA bank of patients. Methods/Design Multiple study designs were adopted. Firstly, prospective cohort with...
Abstract Tuberculosis, a severe infectious disease caused by the Mycobacterium tuberculosis, arouses huge concerns globally. In this study, total of 331,594 TB cases in Zhejiang Province were notified during period 2009–2018 with gender ratio male to female 2.16:1. The incidences demonstrated continuously declining trend from 75.38/100,000 52.25/100,000. Seasonally, presented as low January and February closely followed an apparent rise March April. Further stratification analysis both...
Abstract Background Mass tuberculosis (TB) screening has been recommended in certain high-risk populations. However, population-based interventions have rarely implemented. Whether mass improves health equity is unknown. Methods We implemented a TB intervention among elderly persons (&gt;60 years old) Lanxi County, China. Standardized questionnaires, physical examinations, and chest radiographs (CXRs) were administered to all participants. Systematic testing with computed tomography,...