A5012018934- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- dental development and anomalies
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Dental Radiography and Imaging
- Bone and Dental Protein Studies
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Antimicrobial Peptides and Activities
- Bone Tissue Engineering Materials
- Oral and Maxillofacial Pathology
- Streptococcal Infections and Treatments
- Probiotics and Fermented Foods
- Dental Trauma and Treatments
- Inflammasome and immune disorders
- Bacterial biofilms and quorum sensing
- Dental Implant Techniques and Outcomes
- Dental Research and COVID-19
- Plant-based Medicinal Research
- Bone health and treatments
- Pain Mechanisms and Treatments
- Dental Erosion and Treatment
- Cancer-related molecular mechanisms research
- Drilling and Well Engineering
Northwest University
2023-2024
Air Force Medical University
2012-2023
National Clinical Research
2016-2022
Dentin regeneration is challenging due to its complicated anatomical structure and the shortage of odontoblasts. In this study, a novel injectable cell carrier, nanofibrous spongy microspheres (NF‐SMS), developed for dentin regeneration. Biodegradable biocompatible poly( l ‐lactic acid)‐block‐poly( ‐lysine) are synthesized fabricated into NF‐SMS using self‐assembly thermally induced phase separation techniques. It hypothesized that with interconnected pores nanofibers can enhance...
The NLRP3/caspase-1 inflammasome pathway plays an important role in cellular immune defence against bacterial infection; however, its function human dental pulp tissue and fibroblasts remains poorly understood. We demonstrate that NLRP3 protein expression occurs to a greater extent with irreversible pulpitis than normal reversible pulpitis. Caspase-1 is present active (cleaved) form only caspase-1 are expressed the odontoblast layers tissue, whereas inflamed disrupted cells positive for...
The NLRP3 inflammasome plays an important role in the cellular defense against invading pathogens and is reported to be expressed human dental pulp fibroblasts (HDPFs). However, of HDPFs during pulpal infection inflammation remains unclear.To elucidate function mechanisms that lead its expression activation HDPFs.The test model used lipopolysaccharide (LPS) adenosine triphosphate (ATP) simulate inflammatory environment. Lentiviral vectors encoding short hairpin RNAs were knock down caspase-1...