A5100746051- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Sarcoma Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Blood transfusion and management
- Venous Thromboembolism Diagnosis and Management
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Exercise and Physiological Responses
- RNA Interference and Gene Delivery
- Elbow and Forearm Trauma Treatment
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Hydrogels: synthesis, properties, applications
- Intramuscular injections and effects
- Vagus Nerve Stimulation Research
- Healthcare and Venom Research
- Silk-based biomaterials and applications
- Chemokine receptors and signaling
- 3D Printing in Biomedical Research
- Acupuncture Treatment Research Studies
- Cardiac tumors and thrombi
- Bone and Joint Diseases
Capital Medical University
2025
Beijing Sanbo Brain Hospital
2025
Army Medical University
2008-2024
Southwest Hospital
2008-2024
Chengdu University of Traditional Chinese Medicine
2010-2021
College Art Association
2019
Beijing Chao-Yang Hospital
2017
Second Military Medical University
2013
Changhai Hospital
2013
Cell senescence is a chronic process associated with age-related degenerative diseases such as osteoarthritis (OA). Senescent cells (SnCs) accumulate in the articular cartilage and synovium, leading to OA pathologies. The accumulation of SnCs results senescence-associated secretory phenotype (SASP) inflammation dysfunction. Selective removal by senolytic agent therapeutic strategy has been developed recently. In this study, we examined ability drug ABT263 (navitoclax) clear further evaluated...
Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts cell coculture have attempted to combine the advantages negate drawbacks of constituent types. The aim this study was evaluate chondrogenic outcome articular chondrocytes (ACs) infrapatellar fat pad (IPFP)-derived mesenchymal stem cells (MSCs) direct coculture. ACs IPFP MSCs from same patients with knee osteoarthritis (OA) were cocultured monolayer pellets. monocultures each type also used as...
Background: Recruitment of endogenous stem cells has been considered an alternative to cell injection/implantation in articular cartilage repair. Purpose: (1) To develop a tissue-engineering scaffold with clinically available biomaterials and functionalize the aptamer (Apt19s) that specifically recognizes pluripotent cells. (2) determine whether this could recruit joint-resident mesenchymal (MSCs) when implanted into osteochondral defect rabbit model examine effects regeneration. Study...
Objective Knee osteoarthritis (KOA) is a degenerative joint condition, leading to disability and diminished quality of life. Molecular hydrogen has been proven have antioxidant anti-inflammatory properties, but few studies investigated its effects on osteoarthritis. Our study aims assess the therapeutic potential hydrogen-oxygen mixture (H 2 -O ) inhalation for KOA. Methods In this randomized controlled trial, eligible elderly KOA patients were randomly assigned either Group H or C. Both...
Abstract The cause of hip osteoarthritis (OA) remains unclear, morphologic abnormality was thought to be a contributing factor OA. hypothesis that there were subtle anatomical morphology differences the between normal and OA subjects; objective this study explore these which are predisposing based on CT 3D reconstruction. Ninety-three subjects (186 hips) 66 mild-to-moderate (132 recruited in study. Three parameters head-neck relationship assessed: translation, rotation concavity. Translation...
Background: Long-term outcomes of current clinical interventions for osteochondral defect are less than satisfactory. One possible reason is an ignorance the interface structure between cartilage and subchondral bone, calcified zone (CCZ). However, importance natural CCZ in defects has not been directly described. Purpose: To explore feasibility fabricating trilayer scaffold containing role repair process. Study Design: Controlled laboratory study. Methods: The was prepared by cross-linking...
Background: The reductions of perioperative blood loss and inflammatory response are important in total knee arthroplasty. Tranexamic acid reduced the several studies. However, effect epinephrine administration plus tranexamic has not been intensively investigated, to our knowledge. In this study, we evaluated whether combined low-dose or further compared with alone. Methods: This randomized placebo-controlled trial consisted 179 consecutive patients who underwent primary Patients were into...
软骨内成骨 (EO) 是生长板组织内介导长骨发育的重要生物学过程. 骨类器官能够模拟天然生长板中组织结构与细胞间通信的生理功能, 是一种潜在的长骨发育研究模型. 但如何有效模拟EO过程一直是骨类器官构建中尚未解决的核心难题. 为了模拟EO这一有序的矿化过程, 本文首次揭示了T型电压依赖性钙通道 (T-VDCC) 的Ca v 3.3亚型在EO过程中主要表达于软骨细胞, 并且与软骨细胞的肥大分化呈负相关这一生物学机制, 并基于此机制设计了负载shCa 3.3 ATDC5细胞的明胶甲基丙烯酰 (GelMA) 水凝胶生物墨水, 且进一步评估了这种生物墨水的生物打印性能. 最后, 本研究通过负载Ca 3.3敲低的软骨细胞构建了GelMA水凝胶模型, 成功在体外模拟了EO过程, 为构建分层有序矿化的骨类器官提供了一种新型的生物墨水. 因此, 本研究不仅为骨类器官构建中的EO进程调控提供了潜在的研究靶点, 也为模拟EO过程提供了新的策略.
Abstract Objectives To investigate the role of zyxin‐involved actin regulation in expression level vinculin focal adhesion and collagen production chondrocyte its possible underlying mechanism. Materials methods Chondrocytes obtained from rabbit articular cartilage were used this study. The zyxin, vinculin, as well extracellular matrix ( ECM ) protein type I, II X COL X) chondrocytes compared between zyxin‐knockdown group negative control group, transforming growth factor‐β1 TGF ‐β1)...
Ca2+ has been recognized as a key molecule for chondrocytes, however, the role and mechanism of spontaneous [Ca 2+ ] i signaling in cartilaginous extracellular matrix (ECM) metabolism regulation are unclear. Here we found that Ca signal in-situ porcine chondrocytes was o dependent, mediated by store release. T-type voltage-dependent calcium channel (T-VDCC) influx associated with decreased cell viability expression levels ECM deposition genes. Further analysis revealed expressed both...
Objective To discuss the diagnosis and surgical treatment of primary right ventricular tumors.Methods The results 7 patientss (5 males,2 females; median age,48 years,range,37 to 68 years) with tumors hospitalized from Jan,1999 May,2012 were analyzed.By preoperation echocardiography,cardiac myxoma was diagnosed in 2 cases,and cardiac space-occupying lesion 5 cases.Median sternotomy performed all cases for biopsy or resection tumor.when tumor,extracorporeal circulation arrest performed.Results...
Objective To observe the curative effect of open reduction and internal fixation for capitellum trochlea fractures. Methods A retrospective case series study was performed on 14 patients with fractures without involving lateral column treated by from April 2008 to August 2016. There were four males 10 females, aged 24 62 years (mean, 41.4 years). Dubberley classification type ⅠA in patients, ⅠB three, ⅡA two, ⅡB one, ⅢA ⅢB two. Three combined ipsilateral capitulum radius fractures,...