A5101832036- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Covalent Organic Framework Applications
- Cancer, Hypoxia, and Metabolism
- Advanced Photocatalysis Techniques
- Immune cells in cancer
- Flavonoids in Medical Research
- Fluorine in Organic Chemistry
- Advanced Chemical Physics Studies
- Supramolecular Chemistry and Complexes
- interferon and immune responses
- Metal-Organic Frameworks: Synthesis and Applications
- Seismology and Earthquake Studies
- Seismic Imaging and Inversion Techniques
- Photoacoustic and Ultrasonic Imaging
- Inorganic Fluorides and Related Compounds
- Hydrogen's biological and therapeutic effects
- Photodynamic Therapy Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Reservoir Engineering and Simulation Methods
- Carbon and Quantum Dots Applications
Chongqing Medical University
2023
Dalian Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Wuhan University of Science and Technology
2013-2022
First Hospital of Jilin University
2022
Jilin University
2022
State Key Laboratory of Rare Earth Resources Utilization
2020-2021
Changchun Institute of Applied Chemistry
2020-2021
Academia Sinica
2021
Chinese Academy of Sciences
2020-2021
The development of novel sonosensitizers with outstanding reactive oxygen (ROS) generation capacity and great biocompatibility poses a significant challenge for the clinical practice sonodynamic therapy (SDT). In this work, hemoglobin (Hb) natural metalloporphyrin was first shown to possess potential as sonosensitizer. Compared traditional organic sonosensitizers, Hb had satisfactory sono-sensitizing efficiency because four porphyrin molecules were separated by polypeptide chains. This...
Due to the specific tumor microenvironment (TME) and immunosuppressive state of cancer cells, conventional antitumor therapies face severe challenges, such as high rates recurrence metastasis. Herein, Cu-PPT nanoparticles were synthesized based on copper acetate, p-phenylenediamine, 5,10,15,20-tetra-(4-aminophenyl)porphyrin via oxidative coupling reaction for first time, resultant product was used synergistic photothermal therapy (PTT), photodynamic (PDT), chemodynamic (CDT). The polymer...
Ultrasound (US)-induced sonodynamic therapy (SDT) is an efficient and precise method against tumor, the integration of multiple cancer therapies has been proved as a promising strategy for better therapeutic effects. Herein, first time, multifunctional nanoreactor fabricated by integrating Fe–MIL-88B–NH2, PFC-1, glucose oxidase (GOx) to form urchin-like Fe–MIL-88B–NH2@PFC-1-GOx (MPG) nanoparticles Fenton's reagent, sonosensitizer, tumor microenvironment (TME) modulator. In detail, MPG can...
Abstract Background Calcium ions (Ca 2+ ) participates in various intracellular signal cascades and especially plays a key role pathways relevant to cancer cells. Mitochondrial metabolism stimulated by calcium overload can trigger the opening of mitochondrial permeability transition pore (MPTP), which leads cell death. Methods Herein, pathway for tumour growth inhibition was built via double-activation MPTP channel. Fe doped covalent organic frameworks (COF) synthesised applied as template...
The number of patients who benefit from acquired immunotherapy is limited. Stimulator interferon genes (STING) signal activation a significant component to enhance innate immunity, which has been used realize broad-spectrum immunotherapy. Here, M@P@HA nanoparticles, as STING amplifier, are constructed Briefly, when was targeted into tumor cells, the nanoparticles decomposed with Mn2+ and activated release protoporphyrin (PpIX). Under light irradiation, generated reactive oxygen species...
Background High-intensity focused ultrasound (HIFU) has shown considerable promise in treating solid tumors, but its ultrasonic energy is easily attenuated, resulting insufficient accumulation the target area. Moreover, HIFU ablation alone may inevitably lead to presence of residual which cause tumor recurrence and metastasis. Here, we describe a synergistic regimen combining facilitation with immunomodulation based on novel oxygen-carrying biomimetic perfluorocarbon nanoparticle (M@P-SOP)...
As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis local recurrence.
Cancer deaths are mainly caused by tumor metastases. However, ablation therapies can only target the primary but not inhibit metastasis. Herein, a multifunctional covalent organic framework (COF)-based nanocomposite is designed for synergetic photo-, chemodynamic- and immunotherapies. Specifically, synthesized COF possesses ability to produce singlet oxygen under 650 nm laser irradiation. After being metallized with FeCl3, p-phenylenediamine polymerized on surface of Fe3+ as oxidant. The...
Sonodynamic therapy (SDT) has attracted wide attention for its high tissue-penetration depth capacity. However, developing new kinds of sonosensitizers that are capable generating large amounts reactive oxygen species (ROS) still remains a challenge. Herein, covalent organic framework-titanium oxide nanoparticles (COF-TiO2 NPs) were successfully synthesized by using COF as template. Under ultrasound (US) irradiation, quantities ROS can be generated, and compared with pure TiO2 NPs, the SDT...
Porphyrin-incorporating covalent organic frameworks synthesized at room temperature showed excellent sonodynamic effects.
Nanozymes have been developed as new generation of biomimetic antibiotics against wound infection. However, most new-developed nanozymes based on inorganic particles or hybrid ones usually originate from incompatible raw materials unwanted metal salts, highly limiting their further biomedical usages. To overcome above drawbacks, it is required to develop novel with great antibacterial activity by using biocompatible reagents and endogenous species materials. Here, we demonstrated that bovine...
Fe2+-baicalein-polyethylene glycol (Fe-BaP) nanoparticles were synthesized by a room temperature wet chemical method via coordination between Fe2+ and baicalein. Fe-BaP possessed high photothermal conversion efficiency (η = 45.6%) excellent antitumor efficacy was achieved with the synergistic photothermal/chemodynamic tumor therapy.
Immunotherapy is currently an important adjuvant therapy for malignant tumors besides surgical treatment. However, the heterogeneity and low immunogenicity of tumor are two main challenges immunotherapy. Here, we have constructed a nanoplatform (CP@mRBC-PpIX) to realize reversion acidosis hypoxia through alkali oxygen generation triggered by acidosis. By targeting universal features other than endogenous biomarkers, it was found that CP@mRBC-PpIX could polarize tumor-associated macrophages...
Accurately predicting the dynamic responses of building structures under seismic loads is essential for ensuring structural safety and minimizing potential damage. This critical aspect analysis allows engineers to evaluate how perform various loading conditions, facilitating informed design decisions. Traditional methods, which rely on complex finite element models often struggle with balancing computational efficiency accuracy. To address this challenge, we introduce SeisGPT, a data-driven,...
A detailed singlet potential energy surface survey on the 1 CF 2 + 3 O reaction is carried out in order to clarify mechanisms of difluorocarbene ( ) with oxygen at B3LYP/6-311++G(d,p) level. To determine accurate energies all stationary points, QCISD/6-311++G(d,p) single-point calculations are done by using optimized geometric structures. The title important high temperature processes. Four product channels, P (F CO ), CO), (2F and 4 (FCO FO), have been found reaction. comparable...