A5103039720- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Tendon Structure and Treatment
- Anesthesia and Neurotoxicity Research
- Barrier Structure and Function Studies
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Higher Education Learning Practices
- Vanadium and Halogenation Chemistry
- Neuropeptides and Animal Physiology
- Organ Transplantation Techniques and Outcomes
- RNA regulation and disease
- Orthopedic Surgery and Rehabilitation
- Neurogenesis and neuroplasticity mechanisms
- Intensive Care Unit Cognitive Disorders
- Sleep and Wakefulness Research
- Cardiac Ischemia and Reperfusion
Sun Yat-sen University
2010-2019
Guangdong Pharmaceutical University
2013
Tang Hospital
2013
Xinxiang Medical University
2013
Bridge University
2012
Panyu District Central Hospital
2011
University of Tennessee Health Science Center
2005
The mortality of critically ill patients associated with intestinal ischemia/reperfusion remains very high, which results from multiorgan dysfunction or failure due to injury induced by ischemia/reperfusion. This study was carried out investigate whether can cause cerebral and concomitant memory dysfunction, explore the potential mechanisms.Prospective, controlled, randomized animal study.University research laboratory.Male, adult Sprague-Dawley rats (weighing 250-300 g).Intestinal...
The present study attempts to evaluate the role of Janus kinase/signal transducer and activator transcription (JAK/STAT) signaling in intestinal ischemia/reperfusion (I/R)-induced injury whether immediate ischemic postconditioning ameliorates via attenuation mucosal apoptosis subsequent inhibiting JAK/STAT activation. Anesthetized adult male Sprague-Dawley rats were subjected superior mesenteric artery occlusion consisting 60 min ischemia 2 h reperfusion; sham laparotomy served as controls....
Abstract We examined thalamic input to striatum in rats using immunolabeling for the vesicular glutamate transporter (VGLUT2). Double immunofluorescence viewed with confocal laser scanning microscopy (CLSM) revealed that VGLUT2+ terminals are distinct from VGLUT1+ terminals. CLSM of Phaseolus vulgaris ‐leucoagglutinin (PHAL)‐labeled cortical or VGLUT2 is rare corticostriatal but nearly always present thalamostriatal Electron made up 39.4% excitatory (with constituting rest), and 66.8%...
Huntington's disease (HD) is a neurological degenerative and quinolinic acid (QA) has been used to establish HD model in animals through the mechanism of excitotoxicity. Yet specific pathological changes underlying mechanisms are not fully elucidated. We aimed reveal morphological different striatal neurons model. Sprague-Dawley (SD) rats were subjected unilaterally intrastriatal injections QA mimic Behavioral tests, histochemical immunhistochemical stainings as well Western blots applied...
Studies have confirmed that middle cerebral artery occlusion (MCAO) causes striatal injury in which oxidative stress is involved the pathological mechanism. Increasing evidence suggests melatonin may a neuroprotective effect on ischemic damage. This study aimed to examine morphological changes of different neuron types and by MCAO. The results showed MCAO induced striatum-related dysfunctions locomotion, coordination, cognition, were remarkably relieved with treatment. severe neuronal...
Abstract Histology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, marker protein expression of striatal interneurons transition zone injury induced by 3‐NP. The 3‐NP treatment rats yielded movement, motor coordination, cognitive dysfunction. 3‐NP‐induced lesion core was unvaryingly dorsolateral striatum, with a lesser damage around core, which medium‐sized neurons significantly decreased abundance, but larger survived....
<b><i>Background:</i></b> Melatonin has shown a protective effect against various oxidative damages in the nervous system. Our previous studies have also confirmed its on behavioral dysfunction of experimental rats and injury striatal interneurons induced by 3-nitropropionic acid. The present study aimed to further determine melatonin projection neurons <b><i>Methods:</i></b> Classic histology, immunohistochemistry, Western blotting...
Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function, also regulate pathological processes diseases injury. However, the role of astrocytes dopamine-depleted striatum remains unclear. A rat model Parkinson's disease was therefore established by injecting 10 μL 6-hydroxydopamine (2.5 μg/μL) into right medial forebrain bundle. Immunohistochemical staining used to detect immunoreactivity glial fibrillary acidic protein (GFAP), calcium-binding B...
Interneurons are involved in the physiological function and pathomechanism of spinal cord. Present study aimed to examine compare characteristics Cr+, Calb+ Parv+ interneurons morphology distribution by using immunhistochemical Western blot techniques. Results showed that 1) Cr-Calb presented a higher co-existence rate than Cr-Parv, both them were ventral horn dosal horn; 2) neurons distributing zonally superficial small-sized. neuronswere largest, Cr+ density among them. In deep dorsal...
Striatal neurons can be either projection or interneurons, with each type exhibiting distinct susceptibility to various types of brain damage. In this study, 6-hydroxydopamine was injected into the right medial forebrain bundle induce dopamine depletion, and/or ibotenic acid M1 cortex motor lesions. Immunohistochemistry and western blot assay showed that dopaminergic depletion results in significant loss striatal marked by dopamine- cyclic adenosine monophosphate-regulated phosphoprotein,...