A5103135640- Potato Plant Research
- Alzheimer's disease research and treatments
- Sesame and Sesamin Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Pain Mechanisms and Treatments
- Neurological Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Medical Research and Treatments
- Hydraulic Fracturing and Reservoir Analysis
- Regulation of Appetite and Obesity
- Radiopharmaceutical Chemistry and Applications
- Infection Control in Healthcare
- Clinical practice guidelines implementation
- Intravenous Infusion Technology and Safety
- Vanadium and Halogenation Chemistry
- Aluminum toxicity and tolerance in plants and animals
- Botulinum Toxin and Related Neurological Disorders
- Dye analysis and toxicity
- Biochemical effects in animals
- Amino Acid Enzymes and Metabolism
- Medicinal plant effects and applications
- Menstrual Health and Disorders
- Tryptophan and brain disorders
Guangdong Pharmaceutical University
2011-2024
Guangzhou University
2024
Shenzhen University
2024
Sun Yat-sen University
2016
Zhongshan People's Hospital
2014
University College Hospital at Westmoreland Street
2012
University College London
2012
Massachusetts General Hospital
2009
Harvard University
2009
Alzheimer’s disease (AD) is a progressive neurodegenerative characterized by accumulation of amyloid plaques and neurofibrillary tangles. Amyloid-β (Aβ) widely recognized as key factor in the pathogenesis AD. Aβ1-42, major component plaques, has shown synaptotoxicity associated with impaired long-term potentiation cognitive deficits. Alteration neurogenesis AD patients been reported, while little known about how Aβ1-42 affects hippocampal adult brain. In this study, we injected human peptide...
Leptin is an adipocytokine that primarily secreted by white adipose tissue, and it contributes to the pathogenesis of neuropathic pain in collaboration with N-methyl-D-aspartate receptors (NMDARs). Functional NMDARs are a heteromeric complex comprise two NR1 subunits NR2 subunits. NR2A preferentially located at synaptic sites, NR2B enriched extrasynaptic sites. The roles contribution leptin not clear. present study examined whether important role was related or NMDARs. We used rat model...
Acori graminei Rhizoma (AGR), the dry rhizoma of Acorus gramineus Soland (Araceae), has been used as an Asian traditional herbal medicine against senile dementia, stroke, and cardiovascular disease. Previous studies have revealed neuroprotective effects AGR on neuronal damage learning impairment, while mostly focused effect volatile oil fraction AGR. This study aimed to investigate different extract fractions from Alzheimer disease-like symptoms induced by Amyloid Beta (Aß) 1-42...
Occupational exposure and experimental intoxication of acrylamide (ACR) can produce skeletal muscle weakness ataxia. In this study, we tested whether ACR would affect cerebellar function through the regulation gamma-aminobutyric acid (GABA) glial fibrillary acidic protein (GFAP) expression in cerebellum. Weaning male Sprague-Dawley rats were gavaged with (5, 15, 30 mg/kg, 5 days per week) or saline for 4 weeks. Effects on cerebellum observed. For mg/kg group, no obvious change was observed,...
Alzheimer's disease is closely associated with disorders of neurogenesis in the brain, and growing evidence supports involvement immunological mechanisms development disease. However, at present, role T cells neuronal regeneration brain unknown. We injected amyloid-beta 1-42 peptide into hippocampus six BALB/c wild-type mice BALB/c-nude T-cell immunodeficiency to establish an animal model A further each genotype were same volume normal saline. Immunohistochemistry revealed that number...
Previous studies have demonstrated a neuroprotective effect of extract Ginkgo biloba against neuronal damage, but mainly focused on antioxidation biloba. To date, limited determined whether extrasct has protective damage. In the present study, acrylamide and 30, 60, 120 mg/kg were administered for 4 weeks by gavage to establish mouse models. Our results showed that effectively alleviated abnormal gait poisoned mice, up-regulated protein expression levels doublecortin (DCX), brain-derived...
Abstract As the main tool for reservoir reconstruction of Longdong shale in Changqing Oilfield, coiled tubing bottom seal drag-segment fracturing is currently stage scale promotion, providing support efficient development oil. However, process horizontal construction with large water vertical ratio and super long section, there are problems such as natural depth limitation difficulty setting packer, which seriously affect efficiency quality. In view above problems, this paper carried out...
In recent years, the extraction fraction of volatile oil from Acorus gramineus has significant effects on anti-dementia and improving learning memory animals. To date, limited studies have determined whether A. protective effect neuronal damage. The aim this study was to investigate Alzheimer's disease (AD) mice, by means behavior test, immunohistochemistry western blot methods. study, mice were injected with Aβ1-42 in bilateral hippocampus establish AD model. On seventh day after modeling,...
Abstract Acrylamide is an alkene known to induce neurotoxicity in humans and experimental animals. However, the effects of acrylamide on development myelin sheath are unclear. The present study was explore exposure during pregnancy lactation offspring rats. Four groups thirty-two pregnant Sprague–Dawley rats were exposed 0, 4.5, 9 18 mg/kg BW by gavage from gestational day 15 postnatal 13. corpus callosum nine per group dissected postpartum 14. Structural changes lipid contents sheaths...
Abnormal uterine bleeding (AUB) is a common gynecological issue during reproductive years. Researches on how dietary diversity and patterns influence AUB in Chinese university students are limited, with some studies not clearly defining irregular menstruation. This research investigated the incidence of according to International Federation Gynecology Obstetrics criteria sought identify preventative factors via online questionnaires. Food intake was assessed factor analysis. study analyzed...
To investigate whether Acori Graminei Rhizoma (AGR) volatile oil can reduce inflammatory pain-induced pain-related mood in rats by downregulating NMDARs-ERK 1/2-CREB signaling pathway. Thirty-six male SD were randomly divided into six groups: control group, sham complete Freund's adjuvant (CFA) CFA + 0.1 mL/10 g 0.2 and 0.4 group. Six each group gavaged for 21 days tested mechanical pain hypersensitivity positional avoidance (PEAP) before after drug treatment. In addition, another batch of...