A5026092513- Substance Abuse Treatment and Outcomes
- Functional Brain Connectivity Studies
- Alcohol Consumption and Health Effects
- Genetic Associations and Epidemiology
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Heart Rate Variability and Autonomic Control
- Memory and Neural Mechanisms
- Homelessness and Social Issues
- Prenatal Substance Exposure Effects
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Health, Environment, Cognitive Aging
- Suicide and Self-Harm Studies
- Gambling Behavior and Treatments
- Child Abuse and Trauma
- Tryptophan and brain disorders
- Migration, Health and Trauma
- Health disparities and outcomes
- Action Observation and Synchronization
- Educational and Psychological Assessments
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
SUNY Downstate Health Sciences University
2018-2025
State University of New York
2019-2023
Tel Aviv Sourasky Medical Center
2011-2018
Bar-Ilan University
2017
Tel Aviv University
2011-2016
The evolution of humans as a highly social species tuned the brain to world; yet mechanisms by which coordinate their response online during interactions remain unclear. Using hyperscanning EEG recordings, we measured brain-to-brain synchrony in 104 adults male-female naturalistic interaction, comparing romantic couples and strangers. Neural was found for couples, but not strangers, localized temporal-parietal structures expressed gamma rhythms. Brain coordination three-minute rest,...
Introduction: Research has identified multiple risk factors associated with suicide attempt (SA) among individuals psychiatric illness. However, there is limited research those an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. Methods: We examined lifetime SA in 4,068 AUD from the Collaborative Study on Genetics Alcoholism (23% SA; 53% female; mean age: 38). explored for across other clinical conditions ascertained a interview, polygenic scores comorbid...
The human brain has undergone massive expansion across primate evolution through life amidst multi-layered social attachments; within families, among friends, and between clan members this enabled humans to coordinate their brains with those of others toward the execution complex goals. We examined how attachments facilitate efficient, resource-sensitive performance goals by balancing neural behavioral synchrony. Using hyperscanning EEG, we collected data from male-female pairs in three...
Abstract Predictive models for recovering from alcohol use disorder (AUD) and identifying related predisposition biomarkers can have a tremendous impact on addiction treatment outcomes cost reduction. Our sample ( N = 1376) included individuals of European (EA) African (AA) ancestry the Collaborative Study Genetics Alcoholism (COGA) who were initially assessed as having AUD (DSM-5) reassessed years later either or in remission. To predict this difference recovery status, we analyzed initial...
Reward processing is a vital function for health and survival impaired in various psychiatric neurological disorders. Using monetary gambling task, the current study aims to elucidate neural substrates reward network underlying evaluation of win versus loss outcomes, their association with behavioral characteristics, such as impulsivity task performance, neuropsychological functioning. Functional MRI was recorded thirty healthy, male community volunteers (mean age = 27.4 years) while they...
Reward processing is a vital function for health and survival impaired in various psychiatric neurological disorders. Using monetary gambling task, the current study aims to elucidate neural substrates reward network underlying evaluation of win versus loss outcomes, their association with behavioral characteristics, such as impulsivity task performance, neuropsychological functioning. Functional MRI was recorded thirty healthy, male community volunteers (mean age = 27.4 years) while they...
One of the greatest challenges involved in studying brain mechanisms fear is capturing individual's unique instantaneous experience. Brain imaging studies to date commonly sacrifice valuable information regarding individual real-time conscious experience, especially when focusing on elucidating amygdala's activity. Here, we assumed that by using a minimally intrusive cue along with applying robust clustering approach probe amygdala, it would be possible rate real time and derive related...
Recent evidence suggests that learned self-regulation of localized brain activity in deep limbic areas such as the amygdala, may alleviate symptoms affective disturbances. Thus far amygdala could be obtained only via fMRI guided neurofeedback, an expensive and immobile procedure. EEG on other hand is relatively inexpensive can easily implemented any location. However clinical utility neurofeedback for disturbances remains limited due to low spatial resolution, which hampers targeting...
Background Alcohol use disorder ( AUD ) is known to have adverse effects on brain structure and function. Multimodal assessments investigating volumetric, diffusion, cognitive characteristics may facilitate understanding of the consequences long‐term alcohol circuitry, their structural impairment patterns, impact function in . Methods Voxel‐ surface‐based volumetric estimations, diffusion tensor imaging DTI ), neuropsychological tests were performed 60 individuals: 30 abstinent individuals...
Individuals with alcohol use disorder (AUD) are known to manifest a variety of neurocognitive impairments that can be attributed alterations in specific brain networks. The current study aims identify features connectivity, neuropsychological performance, and impulsivity traits classify adult males AUD (n = 30) from healthy controls (CTL, n using the Random Forest (RF) classification method. predictor variables were: (i) fMRI-based within-network functional connectivity (FC) Default Mode...
Importance Current Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) ( DSM-5 ) diagnoses substance use disorders rely on criterion count–based approaches, disregarding severity grading indexed by individual criteria. Objective To examine correlates alcohol disorder (AUD) across count-based groups (ie, mild, moderate, mild-to-moderate, severe), identify specific diagnostic criteria indicative greater severity, evaluate whether within mild-to-moderate AUD differentiate...
Abstract Background Studies suggest that alcohol consumption and use disorders have distinct genetic backgrounds. Methods We examined whether polygenic risk scores (PRS) for problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in UK Biobank (UKB; N = 121 630) correlate with outcomes four independent samples: an ascertained cohort, Collaborative Study on Genetics Alcoholism (COGA; 6850), population-based cohorts: Avon Longitudinal Parents Children (ALSPAC;...
Individuals with alcohol use disorder (AUD) manifest a variety of impairments that can be attributed to alterations in specific brain networks. The current study aims identify features EEG-based functional connectivity, neuropsychological performance, and impulsivity classify individuals AUD (N = 30) from unaffected controls (CTL, N using random forest classification. included were: (i) EEG source connectivity (FC) the default mode network (DMN) derived eLORETA algorithm, (ii) scores Tower...
Family history (FH) is an important risk factor for the development of alcohol use disorder (AUD). A variety dichotomous and density measures FH have been used to predict outcomes; yet, a systematic comparison these lacking. We compared 4 commonly examined variations by gender race/ethnicity in their associations with age onset regular drinking, parietal P3 amplitude visual target, likelihood developing AUD.
Abstract Neurodevelopmental abnormalities in neural connectivity have been long implicated the etiology of schizophrenia (SCZ); however, it remains unclear whether these patterns are associated with genetic risk for SCZ unaffected individuals (i.e., an absence clinical features or a family history SCZ). We examine polygenic scores (PRS) functional adolescents and young adults without SCZ, this association is moderated by sex age, if similar associations observed genetically related...