A5100458684- Insect Resistance and Genetics
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Plant tissue culture and regeneration
- Insect behavior and control techniques
- Estrogen and related hormone effects
- Entomopathogenic Microorganisms in Pest Control
- Plant Stress Responses and Tolerance
- Insect symbiosis and bacterial influences
- Cancer Genomics and Diagnostics
- Enzyme function and inhibition
- Virus-based gene therapy research
- Prostate Cancer Treatment and Research
- Analytical chemistry methods development
- Mitochondrial Function and Pathology
- Chromatin Remodeling and Cancer
- Cancer Research and Treatments
- Pesticide Residue Analysis and Safety
- Alzheimer's disease research and treatments
- Melanoma and MAPK Pathways
Taiyuan Normal University
2014-2024
Guangdong Academy of Agricultural Sciences
2010-2024
University of Michigan–Ann Arbor
2022-2024
Michigan Center for Translational Pathology
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Institute of Plant Protection
2023
Xiangya Hospital Central South University
2015-2023
Central South University
2015-2023
University of Iowa
2006-2022
Ann Arbor Center for Independent Living
2022
Melanoma is the cancer with highest increase in incidence, and transformation of radial growth to vertical (i.e., noninvasive invasive) melanoma required for invasive disease metastasis. We have previously shown that p42/p44 MAP kinase activated melanoma, suggesting further signaling events are melanoma. The molecular accompany this not well understood. Akt, a molecule downstream PI3K, was introduced into WM35 order test whether Akt overexpression sufficient accomplish transformation....
The red imported fire ant (Solenopsis invicta) is one of the deadliest invasive species that threatens world by disrupting biodiversity, important functions within a natural ecosystem, and community structure. They are responsible for huge economic losses in infested countries every year. Synthetic insecticides, especially indoxacarb, have been broadly used to control S. invicta many years. However, biochemical response indoxacarb remains largely undiscovered. Here, we sublethal doses on...
The use of mulberry leaves has long been limited to raising silkworms, but with the continuous improvement (Morus alba) resource development and utilization, various leaf extension products have emerged. However, fresh trees a specific window time for picking are susceptible adverse factors, such as drought stress. Therefore, exploring molecular mechanism by which resist stress clarifying regulatory network response is focus current work.In this study, natural drought-treated grafted...
Nuclear factor erythroid 2-related 2 (Nrf2) is an important transcription in the defense against oxidative stress. Cumulative evidence has shown that stress plays a key role pathogenesis of Alzheimer's disease (AD). Previous animal and clinical studies had observed decreased expression Nrf2 AD. However, underlying regulation mechanisms AD remain unclear. Here, we used DNA methyltransferases (Dnmts) inhibitor 5-aza-2'-deoxycytidine (5-Aza) to test whether was regulated by methylation N2a...
Manganese superoxide dismutase (MnSOD) levels have been found to be low in human pancreatic cancer [Pancreas26, (2003), 23] and cell lines [Cancer Res.63, 1297] when compared normal pancreas. We hypothesized that stable overexpression of cells with MnSOD cDNA would alter the malignant phenotype. MIA PaCa-2 were stably transfected a pcDNA3 plasmid containing sense or no insert by using lipofectAMINE method. G418-resistant colonies isolated, grown maintained. Overexpression was confirmed two...
Phospholipid glutathione peroxidase (PhGPx) reduces lipid hydroperoxides generated in biomembranes and also uses a wide range of reducing cofactors addition to glutathione. PhGPx is synthesized as mitochondrial form (L-form) nonmitochondrial (S-form). Our aims were determine whether overexpression altered pancreatic tumor cell behavior. Pancreatic cancer lines found by Western blotting have diminished levels PhGPx-immunoreactive protein compared with normal human pancreas. To normalize the...
Endometrial cancer, the most common gynecologic malignancy, is a hormonally-regulated tumor. Response to progestin-based therapy correlates positively with progesterone receptor (PR) expression. However, many endometrial tumors have low levels or loss of PR, limiting clinical application progestin. We evaluated ability epigenetic modulators restore functional PR expression in Type I cancer cells basal PR. Treatment histone deacetylase inhibitor (HDACi) LBH589 induced profound upregulation...
Abstract The foregut, located at the front of digestive tract, serves a vital role in insects by storing and grinding food into small particles. innermost layer foregut known as chitinous intima, comes direct contact with acts protective barrier against abrasive Knickkopf ( Knk ) is required for chitin organization exoskeleton, tracheae wings. Despite its significance, little about biological function foregut. In this study, we found that LmKnk was stably expressed highly before molting...
Brassinosteroids (BRs) can regulate various processes in plant development and defense against environmental stress. In this study, the contribution of BRs degradation isoproturon (IPU) rice has been established. IPU a significant effect on growth, chlorophyll content, membrane permeability. When treated with 1.0 μmol/L 24-epibrassinolide (EBR), BR analogue, associated symptoms poisoning were alleviated as levels growth media decreased. presence EBR, activities several IPU-related...
This study developed and used a modified quick, easy, cheap, efficient, rugged safe (QuEChERS) method coupled with gas chromatography electron capture detection to determine eight pyrethroid pesticide residues in green, red dehydrated peppers. Pyrethroids were extracted acetonitrile, partitioned sodium chloride purified primary secondary amino graphitized carbon black hexane. The QuEChERS extraction conditions optimized, the matrix effects that might influence recoveries evaluated minimized...
Abstract Fall armyworm, Spodoptera frugiperda (J. E. Smith), has become an important agricultural pest worldwide. S. is mainly controlled by the chemical insecticides, whereas frequent application of insecticides would result in resistance development. Insect uridine diphosphate-glucuronosyltransferases (UGTs), as phase II metabolism enzymes, play vital roles breakdown endobiotic and xenobiotics. In this study, 42 UGT genes were identified RNA-seq, including 29 elevated compared to...
Heat shock proteins (Hsps) are highly conserved molecular chaperones that synthesized in response to stress. In this study, we cloned the full-length sequences of Grp78 (glucose-regulated protein 78), Hsp70, Hsp90, and Hsp40 genes from Chinese rice grasshopper Oxya chinensis. The cDNA OcGrp78, OcHsp70, OcHsp90, OcHsp40 contain open reading frames 1947, 1920, 2172, 1042 bp encode 649, 640, 724, 347 amino acids, respectively. Fluorescent real-time quantitative PCR (RT-qPCR) was performed...
Background The oriental fruit fly, Bactrocera dorsalis Hendel, causes serious losses to production and is one of the most economically important pests in many countries, including China, Spalangia endius Walker a pupal parasitoid various dipteran hosts, may be considered potentially ectoparasitic B. dorsalis. However, lack genetic information on this organism an obstacle understanding mechanisms behind its interaction with host. Analysis S. transcriptome essential extend resources species...
Angiogenesis plays a crucial role in tumor development and metastasis. Both bevacizumab cediranib have demonstrated activity as single anti-angiogenic agents endometrial cancer, though subsequent studies of combined with chemotherapy failed to improve outcomes compared alone. Our objective was compare the efficacy cancer models. The cellular effects were examined cell lines using extracellular signal-related kinase (ERK) phosphorylation, ligand shedding, viability, cycle progression...
The modern armamentarium for cancer treatment includes immunotherapy and targeted therapy, such as protein kinase inhibitors. However, the mechanisms that allow cancer-targeting drugs to effectively mobilize dendritic cells (DCs) affect are poorly understood. Here, we report among shared gene targets of clinically relevant inhibitors, high
We studied the parasitism capacity of Spalangia endius as a pupal parasite Bactocera dorsalis after switching hosts. used pupae B. and M. domestica hosts by S. in laboratory. The capacities were compared at different host densities parasitoid ages. two functional responses fitted Holling Type II equation. More parasitized than all densities. ability to control was α/Th (parasitism capacity) = 32.1950, which much stronger that dorsalis, 4.7380. rate wasps had decreased emergence time...
Wolbachia has been shown to induce thelytokous parthenogenesis in Trichogramma species, which have widely used as biological control agents around the world. Little is known about changes of bacterial community after restoring arrhenotokous or bisexual reproduction T. pretiosum. Here, we investigate emergence males pretiosum through curing experiments (antibiotics and high temperature), crossing experiments, high-throughput 16S ribosomal RNA sequencing (rRNA-seq). The results showed that...
BACKGROUND:Cancer cells survival depends on glucose metabolism and ATP. Inhibiting is a possible anticancer treatment. The phosphorylation of 2-deoxy-D-glucose (2-DG), which glycogen analogue, seriously affects the normal glycometabolism process, leading to ATP consumption. Studies showed that 2-DG could regulate RIP c-FLIP. This paper aimed investigate effect c-FLIP expression in HepG2 Hep3B cells, further illustrating mechanism regulating liver cancer cell apoptosis induced by TRAIL....
Life tables were established for trichlorphon-resistant and susceptible Bactrocera dorsalis strains based on the laboratory observations. Trichlorphon-resistant B. strain had longer pupal preoviposition periods, mean generation time compared to trichlorphon strain. Lower fecundity, emergence rate, probability of standard fecundity<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>P</mml:mi><mml:mi>F</mml:mi></mml:msub></mml:math>, shorter female male longevity also...
Lung cancer has been considered as one of the most important causes cancer-related mortality worldwide. To predict lung cancer, researchers identified several molecular markers. However, many underlying markers remain unclear. One these is Rab GDP dissociation inhibitor beta (GDIβ), which related to tumorigenicity, development and invasion. This study was designed analyze biological characteristics GDIβ detect mRNA protein expressions in cells; this also aimed investigate functions...