A5027172871- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Cytokine Signaling Pathways and Interactions
- Drug-Induced Hepatotoxicity and Protection
- Microbial Metabolic Engineering and Bioproduction
- Reproductive System and Pregnancy
- Inflammatory Bowel Disease
- Ferroptosis and cancer prognosis
- Biochemical Analysis and Sensing Techniques
- Biliary and Gastrointestinal Fistulas
- Hepatocellular Carcinoma Treatment and Prognosis
- Venous Thromboembolism Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Ion Channels and Receptors
- Ginger and Zingiberaceae research
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Gastrointestinal Tumor Research and Treatment
- Escherichia coli research studies
The Affiliated Hospital to Changchun University of Chinese Medicine
2024
Tongji Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
Henan Institute of Science and Technology
2019-2021
Army Medical University
2013-2015
Southwest Hospital
2015
Drug-resistant bacteria are a serious threat to global public health. Gram-positive bacterial endolysin preparations have been successfully used fight as novel antimicrobial replacement strategy. However, Gram-negative phage endolysins cannot be applied directly destroy strains due the externally inaccessible peptidoglycan layer of cell wall; this has seriously hampered development endolysin-like antibiotics against bacteria. In study, 3-12 hydrophobic amino acids were successively added...
Accumulating studies revealed that 6-gingerol, a compound extracted mainly from ginger, treats obesity by preventing hyperlipidemia in vivo induced high-fat-diet (HFD). The present study intends to further evaluate the efficacy of 6-gingerol treatment and investigate its potential mechanism. Obese mice were established HFD induction. Bioinformatic analysis was used predict possible pathways enrolled application 6-gingerol. Body weight levels blood glucose lipids examined analyzed for...
Abstract Background Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O -linked β- N -acetylglucosaminylation ( -GlcNAcylation) necroptotic signal molecule receptor-interacting serine-threonine kinase 3 (RIPK3) was reported to exert a protective effect gut inflammation. Our recent study suggested traditional Chinese herbal formula Wu-Mei-Wan (WMW) as effective prescription mouse colitis. However, potential...
Portulacae Herba and Granati Pericarpium pair (PGP) is a traditional Chinese herbal medicine treatment for colitis, clinically demonstrating relatively favorable effect on relieving diarrhea abnormal stools. However, the underlying mechanism remain uncertain.
Ginseng (
Objective To investigate the role(s) of Trps1 in non-anastomotic biliary stricture (NABS) following liver transplantation. Methods Immunohistochemical and histological techniques were used to detect Trps1, E-cadherin, CK19, vimentin, α-SMA, collagen deposition. Human intrahepatic epithelial cells (HIBECs) infected with a adenovirus, or transfected short-interfering RNAs (siRNAs). Reverse transcription polymerase chain reaction (RT-PCR) assays western blotting determine expression levels...
Abstract Cell death is an important physiological and pathological phenomenon in multicellular animals occurs widely various body’s systems. In recent years, researchers have gained a deeper understanding of the mechanisms necrosis apoptosis mammals. addition, many new forms lytic regulated cell (RCD), such as pyroptosis, necroptosis ferroptosis, been discovered, thus enhancing our molecular programmed (PCD) associated signalling pathways well their relationship with diseases. However, RCD...
Wu-Mei-Wan (WMW), a traditional Chinese medicine (TCM) formula, has good effect on the treatment of obesity and been proven helpful to promote metabolism adipose tissue. However, its underlying mechanism remains be studied. This study aims explore potential pharmacological WMW in obesity.Network pharmacology was used sort out relationship between putative targets obesity-related drug or disease targets, which indicated treating from two aspects clinical drugs approved by Food Drug...
<title>Abstract</title> Background: Sepsis remains a life-threatening disease with high mortality rate that causes millions of deaths worldwide every year. However, the molecular mechanism incompletely unknown. Bioinformatics analysis has been widely used in microarray data to identify biomarkers sepsis and perform subsequent potential therapeutic interventions. Methods: The GSE175453, GSE185263 GSE28750 datasets were obtained from Gene Expression Omnibus (GEO) database eQTL comes eQTLGen...