A5074958904- Bacteriophages and microbial interactions
- Spectroscopy and Laser Applications
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Atmospheric Ozone and Climate
- Microbial infections and disease research
- Advanced Chemical Sensor Technologies
- RNA and protein synthesis mechanisms
- Bacterial biofilms and quorum sensing
- Atmospheric and Environmental Gas Dynamics
- Gut microbiota and health
- Reproductive Biology and Fertility
- Tissue Engineering and Regenerative Medicine
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Outbreaks Research
- Pluripotent Stem Cells Research
- Bacterial Identification and Susceptibility Testing
- Fire Detection and Safety Systems
- Plant and fungal interactions
- Rabies epidemiology and control
- Pharmaceutical and Antibiotic Environmental Impacts
- Enzyme Production and Characterization
- Monoclonal and Polyclonal Antibodies Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
Jilin University
2011-2024
State Key Laboratory on Integrated Optoelectronics
2021-2024
Shenyang University
2024
Chinese PLA General Hospital
2018-2022
Southwest University
2022
Guangdong University of Technology
2021
Chinese University of Hong Kong
2009
Prince of Wales Hospital
2009
Shiga University of Medical Science
1998
Yokohama National University
1998
Biofilm formation, one of the most important virulence factors pathogenic bacteria, protects bacteria against desiccation, antibiotics, phages and host immune responses. However, phage-derived depolymerases show antibiofilm activity demonstrate great potential to treat infections caused by biofilm-forming bacteria. In this study, Escherichia coli phage vB_EcoM_ECOO78 was isolated characterized, we observed its ability lyse five out 34 tested E. clinical isolates. The highest titre at a...
A vehicle-deployed parts-per-billion in volume (ppbv)-level off-axis integrated cavity output spectroscopic (OA-ICOS) CH4/C2H6 sensor system was experimentally presented for mobile inspection of natural gas leakage urban areas. For the time-division-multiplexing-based dual-gas system, an antivibration 35-cm-long optical with effective path length ∼2510 m fabricated a high-stability temperature and pressure control design. An Allan deviation analysis yielded minimum detection limit 0.2 ppbv...
Laser-processing technology has been widely used in the ultra-precision machining of diamond materials. It advantages high precision and efficiency, especially field super-hard materials high-precision parts manufacturing. This paper explains fundamental principles laser processing, introduces interaction mechanisms between various types lasers materials, focuses on analyzing current development status modes processing diamond, briefly discusses relevant applications cutting, micro-hole...
Drug-resistant bacteria are a serious threat to global public health. Gram-positive bacterial endolysin preparations have been successfully used fight as novel antimicrobial replacement strategy. However, Gram-negative phage endolysins cannot be applied directly destroy strains due the externally inaccessible peptidoglycan layer of cell wall; this has seriously hampered development endolysin-like antibiotics against bacteria. In study, 3-12 hydrophobic amino acids were successively added...
Staphylococcus aureus ( S. ) is one of the most common clinical pathogenic bacteria with strong pathogenicity and usually leads to various suppurative infections high fatality. Traditional bacterial culture for detection prone diagnosis antimicrobial treatment delays because its long-time consumption low sensitivity. In this study, we successfully developed a quantum dots immunofluorescence biosensor detection. The combined advantages biosensors specificity antigen-antibody immune...
Culture of Desulfovibrio vulgaris in a medium supplemented with 5-aminolevulinic acid and l -methionine- methyl - d 3 resulted the formation porphyrins (sirohydrochlorin, coproporphyrin III, protoporphyrin IX) which groups at C-2 C-7 positions were deuterated. A previously unknown hexacarboxylic was also isolated, its structure determined to be 12,18-didecarboxysirohydrochlorin by mass spectrometry 1 H NMR. These results indicate primitive pathway heme biosynthesis D. consisting following...
Variations in the hepatitis B virus (HBV) genome may develop spontaneously or under selective pressure from antiviral therapy. Such variations confer drug resistance affect replication capacity, resulting failure of therapy.A duplex PCR was used to amplify region reverse transcriptase gene, precore promoter, and basal core promoter HBV genome. Four multiplex primer-extension reactions were interrogate 60 frequently observed variants during Automated MALDI-TOF mass spectrometry (MS) for...
Abstract Background The rapid identification of pathogenic bacteria is important for determining an appropriate antimicrobial therapy pneumonia, but traditional bacterial culture time-consuming and labourious. aim this study was to develop evaluate a DNA microarray assay the simultaneous detection fifteen species directly from respiratory tract specimens in patients with pneumonia. These included Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Escherichia coli,...
Phages were isolated from Staphylococcus epidermidis after exposure of cultures to mitomycin C. Using certain these phages, genes controlling resistance novobiocin, streptomycin, and erythromycin involved in the synthesis adenine riboflavin transferred donor recipient strains S. epidermidis. Interspecific transduction Nov r marker was accomplished between aureus. Attempts transfer penicillin not successful.
Infections caused by antibiotic-resistant Escherichia coli are a threat to human and animal health globally. Phage therapy has made great progress for the treatment of drug-resistant infections, but it is still unclear whether E. resistance antibiotics could change lysis ability phages. In this study, we demonstrate that over expression AmpC, an important β-lactamase ampicillin resistance, promotes phage utilizing OmpA as receptor. strains expressing more AmpC showed higher levels OmpA,...
Abstract Phage is a promising therapeutic agent for treating antibiotic resistant bacteria. However, in the process of treatment, phage may be cleared by immune system and cleaved protease, which could affect efficacy phage. In order to solve above problems, encapsulation usually adopted. this study, we employed metal phenolic network (MPN) efficient protect from cleavage keep cytotoxicity weak. model skin wound infection, encapsulated released response pH change achieve good antibacterial...
Over the past few decades, clinical features of pulmonary cryptococcosis (PC) have progressed; however, there is a lack data on manifestations PC over time. To investigate differences in characteristics across different time periods, we retrospectively reviewed 130 non-acquired immunodeficiency syndrome (AIDS) patients diagnosed with pathologically or microbiologically confirmed from 1990-2020. Among PC, 24 (18.5%) exhibited immunosuppression, and 44 (33.8%) had underlying diseases. In...
Aging causes a decline in ovarian function and may contribute to failure infertility. We investigated the effect of menstrual blood-derived mesenchymal stem cells (MenSCs) their mitochondria on aged mice. performed two treatment protocols: i) ovaries recipient mice were treated vivo with MenSCs 3D alginate gel; ii) injected suspension then incubated mitochondrial gel. Seven days after treatment, harvested for histological assessment by HE staining transcriptomic analysis RNA-seq. Our data...
Abstract A near‐infrared methane (CH 4 ) and ethane (C 2 H 6 dual‐gas sensor system based on off‐axis integrated cavity output spectroscopy was demonstrated. Simultaneous detection of CH C performed using two distributed feedback laser diodes with central wavelengths 1654 1680 nm by time division multiplexing (TDM). TDM the lasers realized a self‐developed master controller digital signal processor. Allan deviations 27.3 parts‐per‐billion in volume (ppbv) for 196.4 ppbv were achieved at an...
Acinetobacter baumannii is an important pathogen of nosocomial infections. Nosocomial outbreaks caused by antibiotic-resistant A. remain a significant challenge. Understanding the antibiotic resistance mechanism critical for clinical treatment. The purpose this study was to determine whole-genome sequence (WGS) extensively drug-resistant (XDR) strain, XDR-BJ83, which associated with outbreak in tertiary care hospital China, and investigate strain. WGS XDR-BJ83 performed using single-molecule...