A5101665750- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Cancer-related Molecular Pathways
- Biochemical effects in animals
- Glioma Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Meat and Animal Product Quality
- Mitochondrial Function and Pathology
- Protein Hydrolysis and Bioactive Peptides
- Glycosylation and Glycoproteins Research
- Meningioma and schwannoma management
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Facial Nerve Paralysis Treatment and Research
- Optical Imaging and Spectroscopy Techniques
- Nutrition, Health and Food Behavior
- Cellular Mechanics and Interactions
- Cancer Mechanisms and Therapy
- Neurofibromatosis and Schwannoma Cases
- Balance, Gait, and Falls Prevention
- Animal Behavior and Reproduction
- Protist diversity and phylogeny
University of Science and Technology of China
2017-2025
Chinese Academy of Sciences
2003-2024
Capital Medical University
2024
Jiangsu University
2024
Beijing Institute of Neurosurgery
2024
Aerospace Information Research Institute
2024
State Key Laboratory of Remote Sensing Science
2024
University of Chinese Academy of Sciences
2024
Nanjing University of Chinese Medicine
2023
Guangdong University of Technology
2023
Two hallmarks for cancer cells are the accelerated cell cycle progression as well altered metabolism, however, how these changes coordinated to optimize growth advantage still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator mitosis, plays critical role biosynthesis in through activating pentose phosphate pathway (PPP). We find Plk1 interacts with and directly phosphorylates glucose-6-phosphate dehydrogenase (G6PD). By G6PD promoting formation of its active...
Abstract Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms controlling protein feeding remain poorly understood. Here we report that in Drosophila , intake-induced inhibition (PIFI) specific to protein-containing food, this effect mediated by a fat body (FB) peptide named female-specific independent transformer (FIT). Upon consumption FIT expression greatly elevated. Secreted fly haemolymph conveys metabolic message brain, thereby promoting release...
Abstract Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH catalyzes interconversion between pyruvate lactate. Aurora-A-mediated phosphorylation LDHB serine 162 significantly increases its activity reducing to lactate, which...
The Aurora A inhibitor alisertib shows encouraging activities in clinical trials against advanced breast cancer. However, it remains unclear whether and how the inflammatory microenvironment is involved its efficacy. Here, we demonstrated that inhibition of directly reshaped immune through removal tumor-promoting myeloid cells enrichment anticancer T lymphocytes, which established a tumor-suppressive significantly contributed to regression murine mammary tumors. Mechanistically, treatment...
Significance Suppression of inhibitory interneurons, termed disinhibition, has been suggested as a conserved circuit mechanism crucial for associative learning. In Drosophila , pair GABAergic neurons negatively regulates aversive olfactory Here we show that these receive suppressive signals directly from group DA through the dopamine receptor DD2R. During odor-electric shock (ES) conditioning, ES-induced dopaminergic (DA) signal restrains inhibition, thereby allowing efficient Moreover, this...
Mitosin (also named CENP-F) is a large human nuclear protein transiently associated with the outer kinetochore plate in M phase. Using RNA interference and fluorescence microscopy, we showed that mitosin depletion attenuated chromosome congression led to metaphase arrest misaligned polar chromosomes whose kinetochores few cold-stable microtubules. Kinetochores of fully aligned often failed show orientation direction spindle long axis. Moreover, tension across their sister was decreased by...
The centrosome is the major microtubule-organizing center in animal cells. Although cytoplasmic dynein regulator Nudel interacts with centrosomes, its role herein remains unclear. Here, we show that Cos7 cells a mother centriole protein rapid turnover independent of activity. During duplication, targets to new later than ninein but earlier dynactin. Its localization requires C-terminal region essential for associations dynein, dynactin, pericentriolar material (PCM)-1, pericentrin, and...
Identifying the neurochemistry and neural circuitry of sleep regulation is critical for understanding various disorders. Fruit flies display sleep-like behavior, sharing essential features with vertebrate. In fruit fly's central brain, mushroom body (MB) has been highlighted as a center; however, its neurochemical nature remains unclear, whether it promotes or wake still topic controversy.We used video recording system to accurately monitor locomotor activity status. Gene expression was...
Abstract Integrated traditional Chinese medicine (TCM) and Western (WM) is a new medical science grounded in the knowledge bases of both TCM WM, which then forms unique modern system China. WM has long history China, made important achievements process clinical diagnosis treatment. However, methodological defects currently published practice guidelines limit its development. The organic integration deeper WM. To realize progression "integration" to "organic integration", targeted...
The fall armyworm (Spodoptera frugiperda) (J. E. Smith) is a widespread, polyphagous, and highly destructive agricultural pest. Global climate change may facilitate its spread to new suitable areas, thereby increasing threats host plants. Consequently, predicting the potential distribution for plants under current future scenarios crucial assessing outbreak risks formulating control strategies. This study, based on remote sensing assimilation data plant protection survey data, utilized...
ABSTRACT The Aurora‐A kinase inhibitor MLN8237 has shown efficacy in clinical trials for advanced breast cancer; however, its use as a monotherapy is limited by significant side effects and modest efficacy. Therefore, combining with other agents at lower doses may provide viable alternative. In this study, we evaluated the combination of BH3 mimetic ABT263 treatment triple‐negative cancer (TNBC). We found that significantly suppressed tumor growth metastasis immunocompetent syngeneic mouse...
Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon types of soft tissue sarcomas. The occurrence intracranial MPNSTs in the sellar region is exceedingly rare. A 37-year-old female, who had undergone transnasal surgery for a pituitary adenoma followed by adjuvant stereotactic radiotherapy 10 years earlier, was diagnosed with an MPNST region. second procedure successfully removed lesion and proton therapy. Three months postoperatively, spontaneous cerebrospinal fluid (CSF)...
Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed a range of solid tumors, which is linked with tumor progression poor prognosis. Importantly, inhibitors are being studied number ongoing clinical trials. However, whether how role the regulation mitotic checkpoint controversial. Additionally, function nuclear-accumulated late G2 phase not clear. Here we show that knockout, inhibition blockade...
Cancer cells have distinctive demands for intermediates from glucose metabolism biosynthesis and energy in different cell cycle phases. However, how regulators glycolytic enzymes coordinate to orchestrate the essential metabolic processes are still poorly characterized. Here, we report a novel interaction between mitotic kinase, Aurora A, enzyme, pyruvate kinase M2 (PKM2), interphase of cycle. We found A-mediated phosphorylation PKM2 at threonine 45. This significantly attenuated enzymatic...
Abstract Background Kelch-like 6 (KLHL6) is a cancer oncogene previously associated with specific human cancers, such as chronic lymphocytic leukaemia. Here, the mechanisms of KLHL6 function were explored in gastric (GC) cells, an vivo experimental tumour model, and prognostic value analysis GC tissue evaluated cohort patients GC. Methods Associations between clinicopathological survival data expression tissues analysed. The effects downregulation cells was investigated using proliferation,...
ATP metabolism during mitosis needs to be coordinated with numerous energy-demanding activities, especially in cancer cells whose metabolic pathways are reprogramed sustain rapid proliferation a nutrient-deficient environment. Although strategies targeting the energy have shown therapeutic efficacy preclinical models, how normal and differentially respond shortage is unclear. In this study, using time-lapse microscopy, we found that displayed unique mitotic phenotypes dose-dependent manner...