A5046523772- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Peptidase Inhibition and Analysis
- Asymmetric Hydrogenation and Catalysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Corporate Taxation and Avoidance
- Catalytic Alkyne Reactions
- Cancer-related gene regulation
- Catalytic Cross-Coupling Reactions
- Sirtuins and Resveratrol in Medicine
- Ferrocene Chemistry and Applications
- Tea Polyphenols and Effects
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Catalytic C–H Functionalization Methods
- Biochemical effects in animals
- Catalysis for Biomass Conversion
Tris Pharma (United States)
2015
GlaxoSmithKline (United States)
2015
The University of Texas at Austin
1990-1995
Trinity University
1991-1995
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective Intramolecular Cyclopropanations of Allylic and Homoallylic Diazoacetates Diazoacetamides Using Chiral Dirhodium(II) Carboxamide CatalystsMichael P. Doyle, Richard E. Austin, A. Scott Bailey, Michael Dwyer, Alexey B. Dyatkin, V. Kalinin, Michelle M. Y. Kwan, Spiros Liras, Christopher J. Oalmann, Cite this: Am. Chem. Soc. 1995, 117, 21, 5763–5775Publication Date (Print):May 1, 1995Publication History Published online1 May...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh enantioselectivity in the intramolecular cyclopropanation of allyl diazoacetates using a novel rhodium(II) catalystMichael P. Doyle, Roland J. Pieters, Stephen F. Martin, Richard E. Austin, Christopher Oalmann, and Paul MuellerCite this: Am. Chem. Soc. 1991, 113, 4, 1423–1424Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February...
SIRT1, the founding member of mammalian family seven NAD(+)-dependent sirtuins, is composed 747 amino acids forming a catalytic domain and extended N- C-terminal regions. We report design characterization an engineered human SIRT1 construct (mini-hSIRT1) containing minimal structural elements required for lysine deacetylation activation by small molecule sirtuin-activating compounds (STACs). Using this construct, we solved crystal structure mini-hSIRT1-STAC complex, which revealed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,2,3-Trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitorsStephen F. Martin, Richard E. Austin, Christopher J. Oalmann, William R. Baker, Stephen L. Condon, Ed DeLara, Saul H. Rosenberg, Kenneth P. Spina, Herman Stein, Cite this: Med. Chem. 1992, 35, 10, 1710–1721Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published...
We have identified SRT2104 (4) as the first direct synthetic SIRT1 activator clinical candidate. The compound was derived from optimization of a previously described imidazo[1,2-b]thiazole scaffold. selected development candidate based on combination biochemical activity and pharmacokinetic profile. in vivo characteristics were superior to those analogues with similar activation profiles. overall preclinical profile suggests that has potential provide therapeutic benefit setting.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”