A5101946196- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Urinary Bladder and Prostate Research
- Cancer-related gene regulation
- Genital Health and Disease
- Prostate Cancer Treatment and Research
- Thyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Sexuality, Behavior, and Technology
- Sperm and Testicular Function
- Bone Tissue Engineering Materials
- TGF-β signaling in diseases
- Pelvic floor disorders treatments
- Acute Myeloid Leukemia Research
- Developmental Biology and Gene Regulation
- Bone Metabolism and Diseases
- Male Reproductive Health Studies
- Glycogen Storage Diseases and Myoclonus
- Hedgehog Signaling Pathway Studies
- Radiopharmaceutical Chemistry and Applications
- Peroxisome Proliferator-Activated Receptors
- Acne and Rosacea Treatments and Effects
- Marriage and Sexual Relationships
- Statistical Methods in Clinical Trials
- Surgical Simulation and Training
Baylor College of Medicine
2023-2024
Shanghai Municipal Center For Disease Control Prevention
2016-2020
Heritage College
2019
Southern Ohio Medical Center
2019
Ohio University
2019
Vanderbilt University Medical Center
2019
Queens Hospital Center
2016
Epizyme (United States)
2010-2012
Tris Pharma (United States)
2009
Brigham and Women's Hospital
2004
A targeted nanoparticle containing docetaxel displays antitumor activity in animals and differentiated pharmacological properties patients with advanced solid tumors.
Little is known about the regulatory signals involved in tendon and ligament formation, this lack of understanding has hindered attempts to develop biologically based therapies for repair. Here we report that growth differentiation factors (GDFs) 5, 6, 7, members TGF-beta gene superfamily are most related bone morphogenetic proteins, induce neotendon/ligament formation when implanted at ectopic sites vivo. Analysis tissue induced by GDF-5, or containing implants currently available...
Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor beta (TGF-beta) superfamily, have been implicated in bone formation and regulation early development. To better understand roles BMPs Xenopus laevis embryogenesis, we cloned a cDNA coding for serine/threonine kinase receptor that binds BMP-2 BMP-4. analyze its function, attempted to block BMP signaling pathway embryos by using dominant-negative mutant receptor. When lacking putative domain was expressed...
Administration of therapeutic proteins by methods other than injection is limited, in part, inefficient penetration epithelial barriers. Therefore, unique approaches to breaching these barriers are needed. The neonatal constant region fragment (Fc) receptor (FcRn), which responsible for IgG transport across the intestinal epithelium newborn rodents, expressed cells adult humans and non-human primates. Here we show that FcRn-mediated functional lung primates this system can be used deliver...
Calorie restriction (CR) produces a number of health benefits and ameliorates diseases aging such as type 2 diabetes. The components the pathways downstream CR may provide intervention points for developing therapeutics treating aging. NAD+-dependent protein deacetylase SIRT1 has been implicated one key regulators in yeast, rodents, humans. Small molecule activators have identified that exhibit efficacy animal models typically associated with including To identify molecular processes induced...
Abstract There is growing evidence to suggest that BMPs are among the signals necessary create embryonic skeleton, but how these regulatory molecules enter pathways of bone formation remains be defined. The earliest steps endochondral formation, consisting mesenchymal condensation and chondrogenesis, have been shown result directly from BMP-2 action. To determine whether transition chondrogenesis osteogenesis occurring later in also BMP activity, we tested effects on immortalized skeletal...
The case presented is consistent with the phenomenon known as Pseudo-Pseudo Meigs Syndrome (PPMS). In it, we describe a young woman newly diagnosed Systemic Lupus Erythematosus presenting ascites, pleural effusions, and an elevated CA-125 level. Although rare, of uncertain etiology, PPMS becoming increasingly recognized in literature. It should be considered differential diagnosis such patients, along search for malignancy.
We have identified SRT2104 (4) as the first direct synthetic SIRT1 activator clinical candidate. The compound was derived from optimization of a previously described imidazo[1,2-b]thiazole scaffold. selected development candidate based on combination biochemical activity and pharmacokinetic profile. in vivo characteristics were superior to those analogues with similar activation profiles. overall preclinical profile suggests that has potential provide therapeutic benefit setting.
Abstract Background Subsequent to the implementation of universal salt iodisation policy, China has all but eliminated iodine deficiency disorders. However, pregnant women are still experiencing mild deficiency. The present study explored factors that could relate in women. Methods In total, 2400 were enrolled using a multistage, stratified, random sampling method Shanghai. Data collected via standardised questionnaire. urine samples and household cooking for detection urinary...
Yohimbine is an Indoloquinolizidine alkaloid derived from the bark of African tree Pausinystalia johimbe, as well unrelated South American Aspidosperma quebracho-blanco. It commonly sold a dietary supplement for purpose enhancing libido, weight loss and natural bodybuilding aids. has high affinity α2-adrenergic receptor, moderate α1 dopamine D2 weak D3 receptors some serotonin receptors. Depending on dosage, can either increase or decrease systemic blood pressure (through vasoconstriction...
Abstract Introduction At present, minimal evidence exists in the literature regarding management of benign prostatic hyperplasia (BPH) patients with a penile prosthesis. While it is considered prudent to address BPH prior prosthesis placement, no formal guidelines exist on this topic and many instances, develop lower urinary tract symptoms secondary after placement. Thus, understanding how safely manage patient population key optimal outcomes. Objective The aim study was understand if who...
You have accessJournal of UrologyEducation Research II (MP39)1 May 2024MP39-18 MEDICAL STUDENT UROLOGY SIMULATION LABORATORY INCREASES KNOWLEDGE OF AND INTEREST IN Alexander S. Iacobucci, Jeffrey Song, Geneva Pantoja, Asad Saleem, Wesley A. Mayer, and Jennifer M. Taylor IacobucciAlexander Iacobucci , SongJeffrey Song PantojaGeneva Pantoja SaleemAsad Saleem MayerWesley Mayer TaylorJennifer View All Author Informationhttps://doi.org/10.1097/01.JU.0001008644.01945.6c.18AboutPDF ToolsAdd to...