A5013649218- Nanoplatforms for cancer theranostics
- Zebrafish Biomedical Research Applications
- Congenital heart defects research
- Advanced biosensing and bioanalysis techniques
- Neurogenesis and neuroplasticity mechanisms
- Electrocatalysts for Energy Conversion
- Nanoparticle-Based Drug Delivery
- Catalysis and Hydrodesulfurization Studies
- Protein Tyrosine Phosphatases
- Electromagnetic Fields and Biological Effects
- Nanomaterials for catalytic reactions
- Catalytic Processes in Materials Science
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Magnetic and Electromagnetic Effects
- Congenital Heart Disease Studies
- Nitric Oxide and Endothelin Effects
- Bioactive Compounds in Plants
- Nigella sativa pharmacological applications
- Biochemical effects in animals
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Natural Compound Pharmacology Studies
- Biological and pharmacological studies of plants
- Phytoestrogen effects and research
State Key Joint Laboratory of Environment Simulation and Pollution Control
2023-2025
Research Center for Eco-Environmental Sciences
2024-2025
Chinese Academy of Sciences
2016-2025
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
University of Science and Technology of China
2013-2023
Sanford Burnham Prebys Medical Discovery Institute
2023
Discovery Institute
2023
Jiangxi University of Traditional Chinese Medicine
2019-2023
Hefei National Center for Physical Sciences at Nanoscale
2015
Large magnetic nanoparticles or aggregates are advantageous in their resonance properties over ultrasmall superparamagnetic iron oxide (USPIO) (NPs), but the former cleared faster from blood pool. Therefore, "smart" strategy of intracellular aggregation USPIO NPs is required for enhanced T2-weighted MR imaging. Herein, employing an enzyme-instructed condensation reaction, we rationally designed a small molecule Ac-Asp-Glu-Val-Asp-Cys(StBu)-Lys-CBT (1) to covalently modify prepare...
Compared to 1H MRI, 19F MRI provides higher selectivity but lower sensitivity. Therefore, the need inject high doses of probe improve its sensitivity for in vivo diagnosis remains a challenge. A "smart" strategy is needed that could locally concentrate low-dose while avoiding fast transverse relaxation probes. Locally self-assembling and disassembling nanoparticles may be an optimal measure achieve this goal. Herein, we report dual-functional 1 glutathione (GSH)-controlled self-assembly...
19F MRI has higher selectivity but lower sensitivity than 1H for in vivo diagnosis. Therefore, to avoid using a high injection dose of the probe while, meantime, maintaining remained challenging. Local self-assembly and disassembly nanoparticles could be one “smart” strategies achieve this goal. Herein, we report dual-functional 1 glutathione (GSH)-controlled subsequent legumain (Lgmn)-controlled its (i.e., 1-NPs). Self-assembly 1-NPs confer magnetic resonance (MR) signals “off” “on”,...
For cancer diagnosis, 1H magnetic resonance imaging (MRI) is advantageous in sensitivity but lacks selectivity. Endogenous 19F MRI signal humans barely detectable and thus has very high A combination of ideal for precise tumor a protease-controlled strategy simultaneous T2 enhancement "Turn-On" not been reported. Here, used click condensation reaction to rationally project dual-functional fluorine probe 4-(trifluoromethyl)benzoic acid (TFMB)-Arg-Val-Arg-Arg-Cys(StBu)-Lys-CBT (1), which...
Zebrafish central nervous system (CNS) possesses a strong neural regeneration ability to restore visual function completely after optic nerve injury (ONI). However, whether neurogenesis of retinal ganglion cell (RGC) contributes functional recovery remains controversial. Our quantitative analysis RGCs in different ONI models showed that almost all survived crush (ONC) model; while over 90% the first 2 weeks with 75% remaining 7 transection (ONT) model. Retrograde labeling from tectum...
Neutrophil migration to inflammatory sites is the fundamental process of innate immunity among organisms against pathogen invasion. As a major sleep adjusting hormone, melatonin has also been proved be involved in various events. This study aimed evaluate impact exogenous on neutrophil injury site live zebrafish and further investigate whether ERK signaling this process. Using tail fin transection model, fluorescently labeled was vivo visualized transgenic Tg( lyz :EGFP), :DsRed) zebrafish....
Dendrobium officinale is a herb in traditional Chinese medicine where D. polysaccharides (DOP) are the main active ingredient. This study aimed at evaluating DOP efficiency inhibiting 1-Methyl-2-nitro-1-nitrosoguanidine (MNNG) induced precancerous lesions of gastric cancer (PLGC) rats through Wnt/b-catenin pathway and analyzing variations serum endogenous metabolites. PLGC was established male Sprague-Dawley (SD) by administering 150 μg/mL MNNG drinking water for 7 months giving 0.1 mL 10%...
The efficient production of hydrogen by aqueous-phase reforming (APR) biomass-derived polyols demands the nanoscale bifunctionality catalyst, including dehydrogenation and decarbonylative C–C bond cleavage. Though nickel-based catalysts have been widely studied in APR reaction, approach to regulate this catalytic system still remains elusive. In work, Ni/CeO2 nanocatalysts different Ni contents were synthesized employed for glycerol. rates cleavage reached optimal balance containing 20–30 wt...
Hypoplastic left heart syndrome (HLHS) is a severe congenital disease (CHD) with likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS limited. We performed whole genome sequencing (WGS) on 183 patient-parent trios identify candidate genes, which were functionally tested in Drosophila model. Bioinformatic analysis WGS data from an index family proband born consanguineous parents prioritized 9 genes rare, predicted damaging...
One of the major topics in magnetobiology is biological effects strong static magnetic field (SMF) on living organisms. However, there has been a paucity comprehensive study long-term SMF an animal's development. Here, we explored this question with zebrafish, excellent model organism for developmental study. In our research, zebrafish eggs, just after fertilization, were exposed to 9.0 T 24 h, critical period post-fertilization development from cleavage segmentation. The exposure following...
Gardenia, as a medicinal and edible herb, has the pharmacological activity of protecting liver cholagogue, but hepatotoxicity induced by chemical component genipin (GP) limits its application. The aim this study was to evaluate acute subacute in normal mice with α-naphthalene isothiocyanate (ANIT)-induced injury. results showed that LD50 510 mg/kg. Genipin exhibited jaundiced at doses 125 mg/kg, 250 500 which increased dose. In 28-day study, 50 mg/kg 100 dose groups some pharmacodynamic...
Dual specificity phosphatase 2 (DUSP2) regulates the activation of members in mitogen-activated protein kinase (MAPK) family, which is involved a variety cellular processes like cell proliferation, differentiation, apoptosis and migration. DUSP2 also expression inflammatory mediators macrophages, however, it remains unknown whether participates macrophage Here, using tail fin injury model zebrafish larvae, we found that deletion inhibited pro-inflammatory cytokines chemokines. Moreover, live...
This study investigated the drug delivery performance of oral co-loaded puerarin(PUE) and daidzein(DAZ) mixed micelles(PUE/DAZ-FS/PMMs) from perspectives pharmacokinetics, pharmacodynamics, tissue distribution. The changes in PUE plasma concentration rats were evaluated based on suspension, single drug-loaded micelles(PUE-FS/PMMs), micelles(PUE/DAZ-FS/PMMs). Spontaneously hypertensive rats(SHR) used to monitor systolic blood pressure, diastolic mean arterial pressure for 10 weeks after...
The catalytic oxidation of carbon monoxide (CO) under ambient conditions plays a crucial role in the abatement indoor CO, which poses risks to human health. Despite notable activity exhibited by Pt-based catalysts CO oxidation, their efficacy is usually diminished self-poisoning issue. In this work, three different Pt/CeO2-based catalysts, have distinct coordinative environments Pt but an identical Pt/CeO2 substrate structure, were synthesized activating catalyst with using temperatures and...
Dual-specificity phosphatase 2 (DUSP2) regulates the activation of members mitogen-activated protein kinase (MAPK) family, which is involved in a variety cellular processes including cell proliferation, differentiation, apoptosis, and migration. DUSP2 also expression inflammatory mediators macrophages; however, it remains unknown whether participates macrophage Here, using tail fin injury model zebrafish larvae, we found that deletion inhibited pro-inflammatory cytokines chemokines....